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Biomedical subjects

M Eronen

Publications and source records attributed to M Eronen.

At least 37 records · Page 2Linked to original sources
PubMed1999

Cohen syndrome: evaluation of its cardiac, endocrine and radiological features.

Cohen syndrome (MIM no. 216550) is an autosomal recessive disorder with a typical clinical picture. Since the first report, most publications have represented single case reports. In this study, our aim was to describe cardiac, endocrine and radiological abnormalities in 22 Cohen patients of Finnish descent. Detailed investigations of the heart revealed the anatomy of the heart to be normal with no evidence for clinically significant mitral prolapse. However, a decreased left ventricular function with advancing age was identified. No significant endocrine abnormalities were found at the examination of pituitary, adrenal and thyroid function. The height was either normal or patients were moderately short (mean height standard deviation score (SDS) - 2) at all ages, associated, however, often with the marked kyphosis. Truncal obesity was seen in 4/22 patients. X-rays of the chest, lumbar and thoracic spine, long bones, ankles and metacarpophalangeal pattern profiles revealed kyphosis, scoliosis and calcaneo planovalgus as common features. Fingers of these patients were slender but short with a characteristic metacarpophalangeal pattern profile.

Abnormalities, Multiple↗
PubMed1998

Abnormal structure of human striatal dopamine re-uptake sites in habitually violent alcoholic offenders: a fractal analysis.

Both animal and human studies imply that aggressive behaviour is associated with increased dopaminergic transmission. Our hypothesis was that impulsive violent offenders have also higher heterogeneity of the striatal dopamine transporter (DAT) density than controls. We performed a fractal analysis in 21 impulsive violent offenders, 10 non-violent alcoholics and 21 controls to measure the heterogeneity and laterality of the striatal DAT density characterised by [123I]beta-CIT single-photon emission tomography (SPET). The [123I]beta-CIT distribution was significantly more heterogeneous in the right striatum of violent offenders than in healthy controls. In addition, in young violent offenders there was no normal left-to-right asymmetry observed in control subjects of the same age. The normalisation of the left-to-right asymmetry may reflect late neurobiological maturation.

Aggression↗
PubMed1998

The psychiatric epidemiology of violent behaviour.

This paper reviews the current state of the debate on the relationship between mental disorder and violent behaviour. Starting from the discussion of methodological approaches to assessing a possible association, the most important studies carried out on the issue in recent years are discussed. Their results concur in supporting the assumption that there is a moderate but reliable association between mental disorder and violence. However, this does not imply that people with mental illness are generally more likely to commit violent acts than members of the general population. An elevated risk of violent behaviour is only evident for specific psychiatric diagnoses and symptom constellations. For schizophrenia and other psychotic disorders, a significant increase in the likelihood to commit violent acts is reported. Substance use disorders and antisocial personality disorder, however, represent a markedly higher risk for violent behaviour. The article further discusses possible determinants of violent behaviour such as psychotic symptoms and comorbidity with substance abuse and considers who is at particular risk of becoming a target of violent acts.

Comorbidity↗
PubMed1998

Self-rated health, physician-rated health and associated factors among elderly men: the Finnish cohorts of the Seven Countries Study.

OBJECTIVES: To study self-rated and physician-rated health, to analyse concordance of the two methods and to examine factors explaining differences between self-rated and physician-rated health. DESIGN: Population-based cross-sectional study. SETTING: Finnish cohorts of the Seven Countries Study. SUBJECTS: 470 men aged 70-89 years. MAIN OUTCOME MEASURES: Self-administered questionnaire and clinical examination. RESULTS: General health status estimated by doctors correlated weakly with self-rated health. The strongest determinants of self-rated health were depression (P < 0.0001), coronary heart disease (P = 0.0112) and dysuria (P = 0.0238). Activity of daily living (P < 0.0001), age (P = 0.0001), coronary heart disease (P = 0.0005) and chronic lung disease (P = 0.0064) were independently related to physician-rated health. CONCLUSION: The discrepancy found in ratings of health between physicians and the subjects themselves can be explained by different appreciation of ageing in the assessment of health status. After adjustment for medical conditions, age did not relate to self-perceived health, whereas there was a significant association between age and doctors' ratings. Depression and symptoms which explained self-ratings were not related to physicians' assessments.

Activities of Daily Living↗
PubMed1997

Outcome of fetuses with heart disease diagnosed in utero.

OBJECTIVE: To review the outcomes of 193 fetuses with cardiac abnormalities detected by echocardiography. METHODS: A total of 422 fetuses between 16 and 41 gestational weeks, referred to paediatric cardiologists for detailed echocardiography, were included in this study. RESULTS: Structural heart defects were found in 55 (28%), isolated arrhythmia in 105 (54%), and other non-structural abnormalities (dilated cardiomyopathy, hypertrophic cardiomyopathy, aneurysm of the foramen ovale, isolated pericardial effusion or echogenic foci) in 33 (17%) of 193 fetuses. Total mortality was 26%. The prognosis was poor in fetuses with structural heart defects; 37 of 55 cases (67%) died in utero or postnatally. Chromosomal abnormality was associated with structural heart defect in 38% of fetuses, of whom 38% died. Among fetuses with isolated arrhythmia survival was 95%. Poor outcome was associated with complete heart block (n = 14) in 2 (14%) fetuses with hydrops and heart rate of less than 55 per minute, and with supraventricular tachycardia (n = 21) in three (14%) neonates delivered prematurely at a mean gestational age of 33 weeks. Furthermore, nine of 12 fetuses (75%) with structural heart defects and arrhythmia died. Among fetuses with non-structural cardiac abnormalities, survival was 73%. Poor outcome was evident in fetuses with dilated cardiomyopathy in eight of 13 (62%) and with hypertrophic cardiomyopathy in one of eight (13%) of cases. CONCLUSIONS: Factors associated with a poor prognosis were: structural heart defect associated with chromosomal abnormality or arrhythmia, congestive heart failure associated with supraventricular tachycardia or complete heart block, especially if delivery occurs preterm; and fetal hydrops with congestive heart failure and atrioventricular valve regurgitation.

Arrhythmias, Cardiac↗
PubMed1996

Risk of homicidal behavior among discharged forensic psychiatric patients.

We studied the risk of homicidal behavior among 281 released male forensic psychiatric patients during the 14-year period 1978-1991. Released patients were about 300 times more likely to commit a homicide than the general male population during the first year outside hospital, and the corresponding risk was 53-fold during a mean follow-up period of 7.8 years. The odds ratio for committing a homicide among all Finnish schizophrenics during the 12-year period 1980-1991 was 9.7, which indicates that previous criminality associated with schizophrenia also increases the risk of homicidal behavior remarkably when compared with schizophrenia per se. We believe that this kind of epidemiological approach is a useful method of identifying and classifying factors associated with very high risk of homicidal behavior and preventing homicidal behavior among high-risk populations.

Adolescent↗
PubMed1996

Mental disorders and homicidal behavior in Finland.

BACKGROUND: Owing to the fact that Finnish police have been able to solve about 95% of all homicides during recent decades and because most homicide offenders are subjected to an intensive psychiatric evaluation, it was possible to examine data on 693 of 994 homicide offenders during an 8-year period. METHODS: The prevalences of mental disorders of the homicide offenders were used to calculate odds ratios (ORs) for the statistical increase in risk associated with specific mental disorders. RESULTS: The results indicate that schizophrenia increases the OR of homicidal violence by about 8-fold in men and 6.5-fold in women. Antisocial personality disorder increases the OR over 10-fold in men and over 50-fold in women. Affective disorders, anxiety disorders, dysthymia, and mental retardation did not elevate the OR to any significant extent (OR < 5.0). CONCLUSION: Homicidal behavior in a country with a relatively low crime rate appears to have a statistical association with some specific mental disorders classified according to DSM-III-R classifications.

Adolescent↗
PubMed1996

Growth and development until 18 months of children exposed to tocolytics indomethacin or nylidrin.

Indomethacin, a prostaglandin synthesis inhibitor, is a more efficient tocolytic than the beta-sympathomimetic nylidrin, but causes more frequent unwanted effects in the neonatal period. In order to elucidate the effects on neurodevelopment, infants randomly exposed in utero to either compound were followed up to 18 months. A total of 93 children (40 exposed to nylidrin and 53 exposed to indomethacin) were examined at the age of 12 months. A detailed neurological examination was carried out in 44 of these infants at the age of 18 months. At the age of 12 months the children in the indomethacin group showed poor outcome (death or severe BPD and/or CP and/or severe ROP) in 23% and the children in the nylidrin group in 5% (p = 0.039, Fisher Exact Test). Concerning the children born during tocolysis the corresponding figures were 73% and 13% respectively (p = 0.002, Fisher Exact Test). The growth of the children did not differ significantly between the two treatment groups. Neurological assessment at the age of 18 months revealed more subnormally scoring children in the indomethacin group, but the differences were not significant. It was concluded that the higher incidence of poor outcome and a lest favourable neurological development in the indomethacin group do not support indomethacin's position as the drug of choice for tocolysis.

Child Development↗
PubMed1996

Schizophrenia and homicidal behavior.

It is generally thought that schizophrenia does not predispose subjects to homicidal behavior. However, many previous studies have suffered from notable methodological weaknesses. In particular, obtaining comprehensive study groups of violent offenders has been difficult. Finnish police have been able to solve about 97 percent of homicides during the last few decades. Because most homicide offenders are subjected to intensive forensic psychiatric examination, we were able to obtain data for 93 homicide offenders with schizophrenia among 1,423 arrested during a 12-year period. Calculations of the odds ratios revealed that the risk of committing a homicide was about 10 times greater for schizophrenia patients of both genders than it was for the general population. Schizophrenia without alcoholism increased the odds ratio more than 7 times; schizophrenia with coexisting alcoholism more than 17 times males.

Adolescent↗
PubMed1996

Pulmonary artery pressure in term and preterm neonates.

Systolic pulmonary artery pressure (PAP) during the first 4 days after birth was determined in 41 healthy term and 46 preterm infants by measuring ductal Doppler flow velocity and systemic arterial pressure (SAP). Among preterm infants, 21 had respiratory distress syndrome (RDS) and 25 did not. Sequential indices within 96 h of age were presented respectively. At the ages of 2 and 12 h the ratio between pulmonary and systemic arterial pressure was significantly higher in term than in preterm infants without RDS (p < 0.05). At the age of 24 h, PAP to SAP ratio was similar in all study groups. Between 48 and 72 h, PAP to SAP ratio was significantly higher in preterm infants with RDS than in infants without RDS (p < 0.05). Our findings indicated that: (1) in healthy fullterm infants pulmonary artery pressure fell to subsystemic level during the first 12 h, indicating the critical time in circulatory transition; (2) prematurity did not affect ductal closure times significantly; and (3) RDS was associated with prolonged ductal patency and delayed postnatal circulatory adaptation characterized by pulmonary hypertension.

Blood Flow Velocity↗
PubMed1996

Factors associated with homicide recidivism in a 13-year sample of homicide offenders in Finland.

OBJECTIVE: Data on persons known to have committed homicide during a 13-year period were studied to determine factors associated with increased risk of repeating homicide. METHODS: Between 1981 and 1993, a total of 1,649 homicides were committed in Finland. In 1,089 cases (66 percent), the offenders received an exhaustive forensic psychiatric examination. Data from reports of these examinations were analyzed to determine whether mental disorder and other factors were associated with homicide recidivism. RESULTS: Thirty-six homicide recidivists were identified. Twenty-four were alcoholics, 23 had a personality disorder, in most cases combined with alcoholism, four had schizophrenia, and two had major depression. Homicidal behavior was ten times more likely in men who had committed a previous homicide than in the general male population. Alcoholism increased the odds ratio of additional homicidal behavior in male homicide offenders about 13 times, and schizophrenia increased the odds ratio more than 25 times. During their first year after release from prison, male homicide offenders were about 250 times more likely to commit homicide than members of the general male population. CONCLUSIONS: The data suggest that mentally abnormal offenders are overrepresented among homicide recidivists in Finland. The risk of repeat homicide appears to be very high during the first year after release from prison.

Adolescent↗
PubMed1995

Risk of homicidal behaviour among persons convicted of homicide.

We studied the risk of homicidal behaviour among persons convicted of homicide using an epidemiological method. The results showed that male homicide offenders are at least 10 times more likely to commit a homicide when compared with general male population. This odds ratio was about 150-fold among offenders who had committed at least four previous aggravated violent crimes as well as homicide.

Adult↗
PubMed1995

Mental disorders and homicidal behavior in female subjects.

OBJECTIVE: Although violent behavior is one of the most important factors that have a detrimental effect on quality of life, there are very few quantitative epidemiological studies published on this issue. In particular, female homicidal behavior has remained poorly studied. This study reveals the association between some specific DSM-III-R disorders and female homicidal behavior. METHOD: The author reviewed forensic psychiatric examination of 127 female homicide offenders in Finland over a 13-year period. RESULTS: Female homicide offenders had about a 10-fold higher odds ratio than the general female population for having schizophrenia or a personality disorder. The disorders with the most substantially higher odds ratios were alcohol abuse/dependence and antisocial personality disorder. CONCLUSIONS: Mental disorders appear to have a statistical relationship with homicidal behavior in countries with relatively low crime rates. On the basis of the data, there may be special subgroups of women among whom the risk of homicidal behavior is very high.

Alcoholism↗
PubMed1994

Increase in cerebral blood flow of right prefrontal cortex in man during orgasm.

The functional anatomy of human emotional responses has remained poorly understood, mainly because invasive experiments in humans are unacceptable due to ethical reasons. The new functional imaging techniques such as positron emission tomography and single photon emission computed tomography have made it possible to study the neurophysiology of living humans noninvasively. We studied the regional cerebral blood flow with semi-quantitative 99mTc-HMPAO single photon emission computed tomography in eight healthy right-handed heterosexual males during organism. The results showed decrease of cerebral blood flow during orgasm in all other cortical areas except in right prefrontal cortex, where the cerebral blood flow increased significantly (P < 0.005).

Adult↗
PubMed1994

Increased incidence of bronchopulmonary dysplasia after antenatal administration of indomethacin to prevent preterm labor.

The aim of this randomized study was to compare the neonatal outcome in infants who have been exposed in utero to indomethacin with that in infants exposed to a beta-adrenergic agonist, nylidrin hydrochloride. Eighty pregnant women threatened with preterm labor between 24 and 34 weeks of gestation were enrolled in the study. An intravenous infusion of nylidrin or enterally administered indomethacin was given for a maximum of 72 hours. If preterm labor recurred, all parturient patients were treated with nylidrin. Indomethacin prolonged gestation significantly more than the beta-adrenergic agonist (6.6 weeks vs 4.5 weeks; p = 0.04). Ten of the forty-two infants exposed to indomethacin and 2 of the 45 infants exposed to nylidrin had bronchopulmonary dysplasia (24% vs 5%; p = 0.02). Among the 28 infants delivered within 120 hours after the start of treatment, the incidences of respiratory distress syndrome (82% vs 29%; p = 0.02), bronchopulmonary dysplasia (73% vs 6%; p = 0.0006), and necrotizing enterocolitis or focal intestinal perforation (27% vs 0%; p = 0.03) were higher among those exposed to indomethacin than among those exposed to nylidrin. We infer that administration of indomethacin to pregnant women threatened with premature labor is associated with an increased risk of bronchopulmonary dysplasia in their infants if delivery occurs early.

Adult↗