Fetal heart rate changes during general anesthesia.
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Biomedical subjects
Publications and source records attributed to M Estefan.
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The first preliminary clinical results with a new Cyclosporin derivative (Dihydrocyclosporin-D) are reported. The compound has no obvious nephrotoxic effect; but it exhibits a hepatotoxic effect, and frequently leads to hypertension. The clinical efficiency cannot yet be judged with certainty.
Monocytes from patients with definite or classical rheumatoid arthritis show a significantly higher release of O2-radicals in the chemiluminescence assay (2925 X 10(3) cpm) than those of healthy volunteers (267 X 10(3) cpm) (p = 0.01). This difference does not appear in a similar test with granulocytes, which in both groups tested show a mean chemiluminescence of 2739 X 10(3) and 2547 X 10(3) cpm. The chemiluminescence of monocytes is clearly time-course dependent: in the morning we saw the least response, at noon the highest. Following our results, corticosteroids lower chemiluminescence significantly (p = 0.05), while non steroidal antirheumatic drugs and long-term therapy with gold compounds, etc., do not affect chemiluminescence.