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Biomedical subjects

M Estenne

Publications and source records attributed to M Estenne.

117 records · Page 7Linked to original sources
PubMedDate not supplied

Respiratory changes in abdominal configuration in supine dogs.

In an attempt to understand the respiratory changes in abdominal muscle length in supine dogs (Ninane et al., 1988), we have recorded the electromyographic (EMG) activity of the transversus abdominis, external oblique, and rectus abdominis in eight supine, lightly anesthetized animals, and we have measured the respiratory changes in anteroposterior (AP) and transverse (T) diameters of the abdomen. Five animals had phasic expiratory EMG activity in the transversus during room air breathing, while only two animals had expiratory activity in the external oblique; no animal had phasic expiratory activity in the rectus. Activation of the transversus during expiration was invariably associated with a decrease in the abdominal T diameter and a rise in gastric pressure. In contrast, the abdominal AP diameter tended to increase. These alterations in abdominal configuration remained unchanged after denervation of the triangularis sterni, but decreased in magnitude when activation of the transversus was reduced by supplemental anesthesia. Conversely, these alterations in abdominal configuration increased in magnitude when expiratory activation of the transversus was increased by hyperoxic hypercapnia. These observations indicate that in supine dogs: (1) Expiratory contraction of the transversus acts primarily to reduce the transverse diameter of the abdomen; (2) This reduction, in turn, promotes an increase in abdominal pressure which results secondarily in an outward motion of the ventral abdominal wall; and (3) The latter may explain why the rectus abdominis, although electrically silent, shortens during expiration below its in situ relaxation length. The present observations also establish that in supine dogs breathing at rest, the abdomen does not move with a single degree of freedom.

Abdomen↗
PubMedDate not supplied

[Septicaemia and spontaneous peritonitis in the cirrhotic (author's transl)].

During a five year period 36 episodes of septicaemia in 32 patients with hepatic cirrhosis were documented. This represents 20% of the patients hospitalized with a decompensated cirrhosis and 1.1% of the patients with non decompensated cirrhosis. In patients with decompensated cirrhosis, enteric Gram-negative organisms were most frequently isolated (91% of the cases) and ascitis was infected in one third of the cases. No primary foci of infection were documented. On the contrary patients with a non decompensated cirrhosis had infection mostly with Gram-positive organisms (82%) and foci of infection (skin, throat) were documented in 38% of the cases. Infection by enteric organisms was associated with higher mortality than infection by non enteric organisms (68% vs 28%). Five patients with inappropriate antibiotic treatment died from septic shock. Spontaneous septicaemia and peritonitis are frequent complications if cirrhosis. There are potentially treatable causes of deterioration in the cirrhotic patient, necessitating prompt recognition and treatment.

Adult↗
PubMedDate not supplied

Inspiratory and expiratory lung pressure-volume curve in healthy males and females.

Quasistatic lung inspiratory and expiratory pressure-volume curves were obtained in 58 healthy nonsmoking males (mean age +/- SD: 42.8 +/- 15.1 years; range 22.70) and 56 healthy nonsmoking females (mean age +/- SD: 41.4 +/- 15.6 years; range: 21-76). Inspiratory and expiratory lung recoil pressures were measured at fixed percentages of TLC (100, 95, 90, 80, 70, 60 and 50%). In both sexes, inspiratory as well as expiratory lung recoil pressures were found to decrease linearly with aging (p less than 0.01 for all r values). There was no significant difference between males and females. At and above the 70% TLC level, the slopes of the age-related decreases in lung recoil were similar for the inspiratory and expiratory curves. At the 60% TLC level, the decrease in expiratory lung recoil was significantly (p less than 0.01) faster than the decrease in inspiratory lung recoil, presumably reflecting the influence of airway opening on the inspiratory pressure in older subjects. The shape of the expiratory PV curve described by the K index of the exponential model was similar in both sexes and changed with aging, K increasing significantly (p less than 0.01). By contrast, the shape of the inspiratory limb of the PV curve did not vary with aging. Consequently, the shape of the inspiratory PV curve cannot be predicted from the expiratory one and has to be measured directly.

Adult↗