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Biomedical subjects

M F Brewer

Publications and source records attributed to M F Brewer.

6 recordsLinked to original sources
PubMed1984

Home versus hospital phototherapy for term infants with hyperbilirubinemia: a comparative study.

Twenty-five term infants with hyperbilirubinemia were selected for phototherapy administered at home if they fulfilled clinical and laboratory criteria designed to exclude any pathologic cause of hyperbilirubinemia. Ongoing nursing surveillance of home phototherapy was provided to assure adequate nursing care. No phototherapy-related complications were noted in the study infants. Effectiveness of phototherapy at home was compared with results in a similar group of 33 infants who underwent standard hospital phototherapy. The average decrease in serum bilirubin concentration was similar for the two groups after the first day of treatment. Duration of phototherapy was longer for infants treated at home. The major motivating factor for study entry appeared to be avoidance of parent-infant separation.

Bilirubin↗
PubMed1978

Effect on nitrogen retention by adults of different proportions of indispensable amino acids in isonitrogenous cereal-based based diets.

Nitrogen retention of adults who consumed diets in which cereals furnished 6.0 g N and 0.9 g of lysine was improved by increasing lysine to 1.8 g without altering other amino acids. In a second experiment, 70% of the 6.0 g of dietary N was supplied by rice + wheat and 30% by mixtures of amino acids so designed that the total intakes of amino acids were equivalent to those in diets containing 6.0 g N from whole egg (E), egg + potato (EP), rice + wheat (RW), rice + soy (RS), wheat + milk (WM) or corn + beans (CB). Mean N balances of young men in descending order were, g/day: E 0.69 +/- 0.23, RS 0.44 +/- 0.15, EP 0.43 +/- 0.09, WM 0.24 +/- 0.16, CB 0.16 +/- 0.13 and RW -0.02 +/- 0.10. In the same order, these diet provided, g/day: lysine 2.6, 1.9, 2.3, 1.6, 1.4 and 1.0; S-acids 2.2, 1.7, 1.6, 2.2, 1.9 and 2.3; and tryptophan 0.7, 0.4, 0.6, 0.5, 0.3 and 0.4. N balances resulting from diets E, RS and EP did not differ significantly from each other but E was superior to CB and RW (P less than 0.01). Relative amounts and propertions of the essential amino acids could be varied without altering nitrogen retention until at least one amino acid became limiting. Several patterns of indispensable amino acids therefore may be equally effective in meeting needs of adults, but both amounts and relative proportions should be considered.

Adult↗
PubMed1978

Nitrogen retention of young men who consumed selection patterns of essential amino acids at a constant nitrogen intake.

Six patterns of essential amino acids were devised to represent different sources or combinations of protein based on a daily intake of 6.0 g of nitrogen from these sources. In each diet, cereals furnished 70% and a specially designed amino acid mixture 30% of the total nitrogen. Nitrogen retention of young men who consumed amino acids equivalent to combinations of rice and soy or egg and potato did not differ from the pattern of egg, and these patterns were superior to a combination of rice and wheat; egg also was superior to corn plus beans and wheat plus milk. Relative amounts and proportions of essential amino acids could be modified without depressing nitrogen retention until one amino acid became limiting or the pattern became imbalanced. Therefore, more than one pattern of amino acids should be recognized as useful for adult human subjects; both minimal and total amounts of essential amino acids need to be considered.

Adult↗
PubMed1977

Lysine and tryptophan in cereal-based diets for adult human subjects.

A basic diet containing rice, wheat, and corn that furnished 6.0 g of nitrogen per day was consumed by health young adults. Two levels of lysine, 900 and 1800 mg, and three of tryptophan, 260, 390, and 520 mg, were tested. Lysine exerted a significant effect (P less than 0.05) on nitrogen retention but tryptophan did not. When consumed in conjunction with at least twice the reported minimal requirements of other essential amino acids, 900 mg of lysine induced mean daily balances of 0.15 +/- 0.18, 0.19 +/- 0.14, and 0.22 +/- 0.21 g, respectively, in response to the three levels of tryptophan; and 1800 mg of lysine caused retentions of 0.75 +/- 0.14, 0.77 +/- 0.21 and 0.71 +/- 0.15 g. These findings are discussed in relation to fulfillment of protein and amino acid requirements of adult human subjects.

Adult↗