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Biomedical subjects

M F Gontier

Publications and source records attributed to M F Gontier.

At least 37 records · Page 2Linked to original sources
PubMed1996

[Rare tumors of the prostate or seminal vesicles. Report of a case of leiomyosarcoma].

An unusual case of leiomyosarcoma of the prostate presented as a recurrent pelvic cystic mass. Prostatic sarcoma are rare in adults with a poor prognosis. It is often difficult to determine a definite origin. The authors reviewed the differential diagnosis with pseudosarcoma, inflammatory fibrosarcoma and others rare tumors of the prostate and the seminal vesicle.

Diagnosis, Differential↗
PubMed1995

[Spinal melanocytic schwannoma with malignant course. Microscopic and ultrastructural study of a case].

The authors report a case of recurrent pigmented intraspinal schwannoma with malignant progression. Electron-microscopic study confirmed that melanin pigment was produced by tumor cells and that these cells were derived from the nerve sheath. The histogenesis of pigmented tumors is explained by their neural crest origin and the problem of differential diagnosis of the malignant form with melanoma is discussed.

Adult↗
PubMed1994

[Acquired cutaneous osteomatosis. A primary monomelic form].

Eight cases of sporadic acquired primary osteoma cutis have been reported in the literature. Age at onset varies from 16 to 55 years with a mean of about 35 years. The sex ratio is 1 and a wide range of localizations have been reported. There is no known treatment. We report a new case of primary osteoma cutis observed in an adult. The monomelic feature of this case has not been reported previously. The patient was 76 years old and had multiple painless, stone-like formations at several sites on the left thigh and leg since the age of 40. Histological examination of skin biopsies showed a perfectly differentiated bone tissue in the dermal layer. There was no similar family history nor abnormal morphotype. Likewise, the absence of laboratory signs of pseudohypoparathyroidism, together with the late and spontaneous onset allowed us to eliminate hereditary Albright's osteodystropy or secondary osteomatosis due to a local pathological process. Despite the late onset, the monomelic character of the osteomas observed and the association of hemicorporeal hypertrophy and linear basocellular naevi reported in the literature would suggest a hamartomatous origin rather than a metaplasic process in this patient.

Adolescent↗
PubMed1989

Prognostic value of bone marrow biopsy in chronic lymphoid leukemia. A study of 98 initial bone marrow biopsies.

This study deals with bone marrow biopsies (MB) performed at the initial assessment of our 98 patients included in the French LLC 80 and LLC 85 trials. The prognostic value of the type of medullary invasion was confirmed, with a 6-year survival rate of 44% for the diffuse type (D = 42 patients) as against 68.4% for the non-diffuse type (ND = 56 patients) (p = 0.01). However, comparison of these 2 groups showed a significant difference for 19 of the 25 parameters studied, the differences always being to the prognostic disadvantage of the diffuse group. Bone marrow involvement (BMI) was very closely correlated with the ABC staging system (p less than 0.001). Despite more frequent disease progression among the cases of diffuse BMI, the survival rates in stage A patients were similar: 73.9% for 48 ND patients as against 59.6% for 19 D patients (p greater than 0.50). The ABC system of classification seems more discriminating than that recently proposed by Rozman specially for identifying the favorable groups.

Aged↗
PubMed1987

[Pseudotumoral amyloidosis of the orbit].

A case of orbital amyloid pseudotumour is reported; this rare condition typically present as a ptosis followed by slowly growing orbital neoplasm, in middle-aged women. CT-scan disclose an extra-conal, extra-osseous, calcified mass; preoperative diagnosis of this rare condition might help in avoiding recurrence, probably due to incomplete excision. Pathophysiology of these amyloid deposits remain unknown.

Amyloidosis↗
PubMed1986

[Familial cardiomyopathy caused by carnitine deficiency].

The authors report a familial case of carnitine insufficiency presenting in two out of seven children as a severe, isolated, hypertrophic and hypokinetic cardiomyopathy. The etiology was confirmed by histological study and measurement of carnitine concentrations in the blood and muscle. The evolution was spectacular with specific therapy. Left ventricular hypokinesia regressed completely within 18 months (fractional fibre shortening increased from 10 to 33% and the SCI from 26 to 55% in the more severe of the two cases). Hypertrophy and dilatation decreased significantly. This is a so-called intermediary form of carnitine insufficiency and very unusual because of the isolated cardiac involvement. These cases underline the value of systematic muscle biopsy with measurement of carnitine concentrations in the investigation of all cases of supposed primary cardiomyopathy, especially as a rapid improvement can be obtained by specific replacement therapy.

Adolescent↗
PubMed1986

[Double breast and vertebral plasmacytoma. Acute myeloblastic leukemia 8 years later].

We report in a 40 year-old woman a bifocal mammary and vertebral plasmocytoma attended by surgery and "preventive" chemotherapy. Eight years later, an acute and apparently non secondary myeloblastic leukemia is observed without sign of diffuse myelomatosis. Plasma cell tumors of the breast are uncommon. Eleven cases have been published, combining solitary plasmocytoma and infiltration occurring in multiple myeloma.

Adult↗
PubMed1984

[The extemporaneous examination: the decisive step in the surgical strategy in breast lesions].

Research into breast diseases is developing in all directions. In particular, there has been great progress in the fields of cytology, radiology, isotope studies, thermography and ultrasonography. The diversity of these methods reflects the complexity of the diagnosis. No one method is infallible. We therefore consider that the frozen section examination should be an integral part of a breast surgery. It should be the decisive step in the operative strategy, as breast surgery is associated with important consequences: re-operation is always difficult and a radical operation is irreversible. Frozen section examination can reduce these risks.

Breast Diseases↗