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Biomedical subjects

M F Gonzalez

Publications and source records attributed to M F Gonzalez.

65 records · Page 4Linked to original sources
PubMed1984

Influence of converting-enzyme inhibition on rat des-angiotensin I-angiotensinogen.

The effects of high plasma renin levels on plasma levels of both total immunoreactive angiotensinogen (direct radioimmunoassay) and intact angiotensinogen measured by angiotensin I released by renin (indirect assay) were studied in sodium-depleted rats both with and without captopril treatment and in adrenalectomized rats. The direct assay measures both intact angiotensinogen and des-angiotensin I-angiotensinogen, its residue cleaved by renin. The indirect assay measures only intact angiotensinogen. Neither sodium depletion, captopril treatment, nor adrenalectomy modified the circulating levels of total angiotensinogen. However these treatments produced a decrease in intact angiotensinogen that was in proportion to the elevation of renin levels. The difference between the two assays for angiotensin represents the level of des-angiotensin I-angiotensinogen and correlated satisfactorily with the plasma levels of renin. Identical correlations were observed in adrenalectomized rats and captopril-treated rats. We conclude that des-angiotensin I-angiotensinogen levels are an index of activation of the renin-angiotensin system dependent on the circulating level of renin.

Adrenal Glands↗
PubMed1984

Acquired factor IX inhibitor in a patient with adenocarcinoma of the colon.

The association of an acquired inhibitor to factor IX and adenocarcinoma of the sigmoid colon is reported here for the first time. Unlike the lupus anticoagulant, the inhibitor identified did not exhibit marked prolongation of the clotting time using a highly diluted thromboplastin nor was the kinetic behavior of the inhibitor-factor IX interaction time-dependent. Administration of prednisone was associated with the return of the activated partial thromboplastin time to normal values, at which time the tumor was excised and corticosteroids discontinued with no evidence of subsequent factor IX inhibitor activity.

Adenocarcinoma↗
PubMed1984

Continuous intravenous infusion combination chemotherapy for head and neck squamous cell carcinoma.

42 consecutive patients with head and neck squamous cell carcinoma were entered into a multi-agent chemotherapy protocol including: bleomycin and Cis-platinum (in continuous infusion), sequenced with methotrexate and Vinblastine (by bolus infusion). Hydroxyurea was substituted for bleomycin when the accumulative dose of bleomycin reached 400 units. 9 of 11 patients with untreated disease responded to chemotherapy, with 36.4% showing complete response following the second cycle. After completion of all therapy, complete response had occurred in 10 patients and partial response in 1. At a median follow-up of 1 year, 9 patients are disease-free, and the median duration of response has not yet been reached. For recurrent disease, the overall regression rate is 45.1% (14/31). The median duration of response is 6.5 months, with responding patients showing a median survival of 8.7 months and non-responders, 5.4 months. The data for response and survival are comparable to previous studies and suggest that toxic manifestations may be mitigated by careful attention to nutrition and production of an anabolic state prior to therapy.

Aged↗
PubMed1984

Fetal frontal cortex transplant (14C) 2-deoxyglucose uptake and histology: survival in cavities of host rat brain motor cortex.

Fetal frontal neocortex from 18-day-old rat embryonic brain was transplanted into cavities in 30-day-old host motor cortex. Sixty days after transplantation, 5 of 15 transplanted rats had surviving fetal transplants. The fetal cortex transplants were physically attached to the host brain, completely filled the original cavity, and had numerous surviving cells including pyramidal neurons. Cell lamination within the fetal transplant was abnormal. The (14C) 2-deoxyglucose uptake of all five of the fetal neocortex transplants was less than adjacent cortex and contralateral host motor-sensory cortex, but more than adjacent corpus callosum white matter. The results indicate that fetal frontal neocortex can be transplanted into damaged rat motor cortex. The metabolic rate of the transplants suggests they could be partially functional.

Animals↗
PubMed1983

The effects of converting enzyme inhibitors on plasma angiotensinogen and plasma aldosterone in sodium-depleted rats.

Plasma angiotensinogen was measured by two different methods in three groups of sodium-depleted rats: control rats, captopril-treated rats and enalapril-treated rats. The enzymatic method of measurement is an exhaustion technique which measures the amount of angiotensin I liberated from plasma by an excess of renin. Direct radioimmunoassay measures both angiotensinogen and its inactive residue, des-angio I-angiotensinogen, and the difference between the results of both methods can be used as an indirect measurement of plasma des-angio I-angiotensinogen. Both converting enzyme inhibitors decreased blood pressure, stimulated renin secretion, decreased plasma angiotensinogen and increased des-angio I-angiotensinogen. Plasma des-angio I-angiotensinogen levels were positively correlated with plasma renin levels. In converting enzyme inhibitor-treated rats, plasma aldosterone was slightly, but not significantly, lower than in control rats. Although plasma aldosterone was significantly correlated with plasma renin both in control rats and converting enzyme inhibitor-treated rats, plasma renin was elevated 10-fold in treated rats.

Aldosterone↗
PubMed1977

Inherited combined deficiency of factor V and factor VIII: report of a case with normal factor VIII antigen and ristocetin-induced platelet aggregation.

A patient with inherited combined deficiency of factor V and factor VIII is reported, who demonstrated normal levels of factor VIII antigen and plasma cofactor for ristocetin-induced platelet aggregation. The relationship of this condition to classical hemophilia and von Willebrand's disease is discussed. The data presented suggest that multiple loci on at least 2 chromosomes are necessary for the normal expression of factor VIII activity.

Adult↗
PubMed1976

Paradoxical increased feeding following glucose infusions in recovered lateral rats.

Glucose infusions increased feeding in recovered lateral hypothalamic (LH) lesioned rats in constrast to its suppressant effect in sham-lesioned rats and in rats with lesions unilateral, asymmetrical or anterior to LH. This paradoxical enhancement of eating by glucose was predicted from similar effects seen in vagotomized rabbits and general parallels observed in ingestive behavior after LH lesions and vagotomy. We conclude that an important component in the short-term control of food intake is a vagal-LH circuit and that a modification of the classic notion of the LH as an excitatory "feeding center" is needed.

Animals↗