PubMed Health⌕ Search

Biomedical subjects

M F Greene

Publications and source records attributed to M F Greene.

66 records · Page 4Linked to original sources
PubMed1986

Prenatal sonographic diagnosis of congenital hemivertebra.

The prenatal sonographic diagnosis of spinal abnormalities associated with neural tube element malformations has been well described; however, the diagnosis of fetal skeletal anomalies of the vertebral bodies with a neurologically intact spine has received little attention. Three cases of congenital hemivertebra should alert the sonographer to search for other congenital defects and for orthopedic complications of vertebral body malformations in childhood. Prior knowledge of the presence of an abnormal vertebral body can alert the pediatrician to watch for early signs of problems such as scoliosis or kyphoscoliosis, and to plan surgery if necessary.

Adult↗
PubMed1985

Delay in the fetal globin switch in infants of diabetic mothers.

In the normal fetus, a switch from production of hemoglobin F (alpha 2 gamma 2) to hemoglobin A (alpha 2 beta 2) occurs at 28 to 34 weeks of gestation. In the fetus with beta-hemoglobinopathy or beta-thalassemia, this switch proceeds despite the morbidity that results when production of beta-globin is abnormal or reduced. Since insulin has recently been shown to induce renewed expression of some inactive genes, we studied globin biosynthesis during the natural evolution of the fetal globin switch under conditions of hyperinsulinemia, which occurs in infants of diabetic mothers. Such infants develop in a hyperglycemic environment, which produces reactive hyperinsulinemia. The normal increase in beta-globin production from pre-switch levels did not occur in 9 of 10 such infants at term, as compared with 11 normal infants, in whom the switch occurred by 36 to 39 weeks of gestation (P less than 0.0001). The delay in the switch from gamma-globin to beta-globin in this unique clinical setting may allow identification of physiologic factors that can modulate developmental gene suppression.

Erythropoietin↗
PubMed1985

Pregnancy complicated by homozygous hypercholesterolemia.

The course of pregnancy in a woman with homozygous type IIa hypercholesterolemia is described. Despite prepartum cholesterol levels as high as 700 mg/dL, her cholesterol level increased further during gestation. Pathological examination of the placenta did not reveal insufficiency or vasculopathy.

Adult↗
PubMed1985

Use of the subcutaneous heparin pump during pregnancy.

Six patients requiring anticoagulation during pregnancy were managed with a continuous-infusion subcutaneous heparin pump. There were no cases of recurrent thrombosis; however, five of the six patients had major or minor bleeding complications despite therapeutic partial thromboplastin time levels.

Adolescent↗
PubMedDate not supplied

Issues in implementing prenatal screening for cystic fibrosis: results of a working conference.

PURPOSE: To summarize a conference convened to examine how cystic fibrosis screening might appropriately be introduced into routine prenatal practice. METHODS: Participants included experts from various relevant disciplines. Systematic reviews and data from individual trials were presented; issues were identified and discussed. RESULTS: Judged by published criteria, prenatal cystic fibrosis screening is suitable for introduction. Screening can be performed cost-effectively by identifying racial/ethnic groups at sufficient risk and then using either of two models for delivering laboratory services. Validated educational materials exist. Ethical issues are not unique. CONCLUSIONS: Once adequate facilities for patient and provider education, testing, counseling, quality control, and monitoring are in place, individual programs can begin prenatal screening for cystic fibrosis.

Clinical Trials as Topic↗
PubMedDate not supplied

The causes of high-order multiple gestation.

Most recent reviews of multiple gestations have reported that the major cause of triplet and quadruplet pregnancy is therapy with human menopausal gonadotropin (hMG). In an attempt to decrease the number of high-order multiple gestations due to hMG, serial ovarian ultrasound evaluation was introduced in the mid-1970s. To assess the impact of changing technology on the causes of high-order multiple gestation, we reviewed the experience at our institution from 1983 to 1987. During this time period, 35,119 deliveries were performed, including 13 triplet and 2 quadruplet deliveries. Of the triplet and quadruplet pregnancies, 3 (20%) patients conceived spontaneously, 11 (73%) conceived in association with ovulation induction, and 1 (7%) conceived during an IVF cycle. Of the pregnancies associated with ovulation induction, 9 (82%) were associated with clomiphene therapy and only 2 (18%) with hMG therapy. Of the clomiphene patients, 6 (67%) conceived at a dose of 50 mg per day for five days and 5 (55%) conceived during the first cycle. At the present time, in our institution, hMG therapy is no longer the major cause of triplet and quadruplet pregnancies. It is possible that serial serum estradiol and ovarian ultrasound monitoring of hMG cycles has contributed to the low number of hMG-induced triplet and quadruplet pregnancies that we observed.

Adult↗