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Biomedical subjects

M F Kenda

Publications and source records attributed to M F Kenda.

8 recordsLinked to original sources
PubMed1986

[Effect of the anti-arrhythmia agent ethmozin on the refractory period of the accessory pathway in Wolff-Parkinson-White syndrome].

Sudden onset of atrial fibrillation can be very dangerous in patients with WPW syndrome, because it may result in high ventricular rate. The ventricular rate depends upon the length of the effective refractory period (ERP) of the accessory pathway. It is appropriate, therefore, to test newer antiarrhythmic agents on their effect on the ERP of the accessory bundle. 13 patients underwent the studies. Ethmozin was given intravenously 1 mg/kg body weight. The ERP increased significantly after Ethmozin (p less than 0.05). The increase was more prominent in those patients who had longer basal values of ERP (greater than 300 ms), as compared with the patients with shorter values (less than 300 ms); the latter revealed at most a slight lengthening of the ERP. Ethmozin exerts a favourable effect on the accessory pathway, however, the effectiveness of this substance is insufficient in patients, who are at risk because of a very short ERP.

Anti-Arrhythmia Agents↗
PubMed1984

Electrophysiological effects of ethmozin on sinus nodal function in patients with and without sinus node dysfunction.

The electrophysiological effects of intravenously administered ethmozin (1 mg kg-1) on sinus node function were examined in 32 patients. Based on their clinical data and the results of the initial study, patients were subdivided into group A (n = 12), those with sick sinus syndrome and sinus node recovery time (SNRT) greater than 1500 ms, and group B (n = 20), those without overt sinus node dysfunction and a normal SNRT. The mean sinus cycle length did not change significantly in either group after ethmozin . SNRT was prolonged by ethmozin in group A whereas in group B the increase of SNRT was not significant. Corrected SNRT increased after ethmozin in both subgroups but with a much more pronounced increase in group A. Sinoatrial conduction time was not significantly changed in any group. The lengthening of SNRT in the majority of patients with sick sinus syndrome implies that ethmozin might prolong post-tachycardia pauses in these patients. This drug should therefore be administered cautiously to persons with signs indicative of dysfunction of the sinus node.

Adolescent↗
PubMed1984

The influence of a therapeutic dose of nitroglycerin on invasive and non-invasive parameters of left ventricular performance in coronary heart disease.

To assess the influence of a therapeutic dose of 0.5 mg sublingual nitroglycerin (NTG) on left ventricular performance, 32 patients with coronary heart disease were studied. After routine coronary angiography the patients underwent cinearteriography and phonomechanocardiography before and four minutes after NTG administration. After NTG, end-diastolic pressure and systolic aortic pressure fell significantly, while heart rate, ejection fraction and dp/dt increased. After NTG, a significant prolongation of the pre-ejection period index (PEPI) and isovolumetric relaxation time (IVRT), increase in the PEP/LVET ratio and decrease of the "a" wave of the apexcardiogram were found. The usual therapeutic sublingual NTG dose causes profound haemodynamic changes which are due to decreased preload and afterload and altered contractility induced by NTG.

Cardiac Output↗
PubMed1982

Induced concealed dissimilar atrial rhythms.

Electrophysiologic studies, including intra-atrial recordings and atrial stimulation, were performed in two patients with suspected sick sinus syndrome. Premature atrial stimuli induced atrial flutter in both patients. The arrhythmia was concealed, i.e., it was recordable only by intracavitary electrogram and invisible on surface electrocardiogram. In one case, simultaneous atrial fibrillation could be recorded in a segment of the right atrium. In this patient, the rhythm on the surface electrocardiogram changed during the study to "upper nodal" rhythm, though the atrial electrogram showed continuation of A waves at the same rate as before during sinus rhythm. It seems that atrial changes, which are frequently encountered in sick sinus syndrome, are a predisposing factor for spontaneous or inducible concealed atrial arrhythmias.

Atrial Flutter↗
PubMed1982

Panconductional defect in mixed connective tissue disease: association with Sjogren's syndrome.

A patient in whom mixed connective tissue disease in association of Sjögren's syndrome had previously been diagnosed, experienced a syncopal attack. Electrocardiographic monitoring revealed periods of profound sinus bradycardia, sinus arrest with slow junctional escape rhythm, and first degree atrioventricular block during several episodes of dizziness. Complete right bundle branch block was a constant finding in this patient. Sinoatrial conduction time and sinus node recovery time were prolonged. Coronary heart disease was excluded by normal coronary arteriographic findings. This patient represents a rare case of cardiac involvement in mixed connective tissue disease.

Bundle-Branch Block↗