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Biomedical subjects

M F Mafee

Publications and source records attributed to M F Mafee.

160 records · Page 9Linked to original sources
PubMedDate not supplied

Enlargement of the vestibular aqueduct.

Enlarged vestibular aqueduct, a recently identified anomaly, is typified by an enlarged vestibule, dilation of the ampullated portions of the horizontal and superior semicircular canals, an abnormal cochlea, and hearing loss. In the case described a 16-year-old boy had congenital hearing loss, episodic vertigo, and abnormal vestibular function testing. Tomograms and CT scans confirmed the diagnosis of bilaterally enlarged vestibular aqueducts. The vertiginous episodes decreased in frequency and severity with a no-salt-added diet. The authors conclude that the enlarged vestibular aqueduct is associated not only with other structural inner ear abnormalities and hearing loss, but also with abnormal vestibular function.

Adolescent↗
PubMedDate not supplied

Dynamic computerized tomography in the assessment of hemangioma.

Three hemangiomas of the face and orbit are studied with dynamic computerized tomography (CT). This noninvasive technique has the advantage of simultaneous bone and soft tissue visualization at the time of peak contrast enhancement, and it precludes the potential complications of arteriography and biopsy. The hemangiomas are precisely delineated with intense contrast; the sharp peak and rapid uninterrupted runoff of the computer-generated plot of contrast concentration (CT number) versus time is characteristic of this lesion. It is suggested that the progress of hemangioma involution may be documented by the change in contrast distribution in sequential dynamic CT studies. Dynamic CT is recommended for the evaluation of head and neck vascular tumors.

Adult↗
PubMedDate not supplied

CT characteristics of orbital pseudotumors and other orbital inflammatory processes.

Orbital pseudotumor is a nonspecific inflammatory process of unknown etiology that may mimic a true orbital neoplasm, specifically lymphoma. It exhibits a highly variable clinical and radiographic presentation. Thirty-nine patients with a presumptive diagnosis of orbital inflammatory disease were examined with CT and evaluated with respect to 13 findings associated with inflammatory disease of the orbit. Pseudotumor was included as part of the differential diagnosis in 25 patients. Twenty-one cases received a final (clinical) diagnosis of pseudotumor. The remainder were comprised of a broad range of orbital inflammatory conditions. Key radiographic features required to entertain or exclude the diagnosis of pseudotumor included establishing the presence of an orbital mass, extraocular muscle enlargement, bony erosion, enhancement, and associated paranasal sinus disease.

Adult↗
PubMedDate not supplied

Laryngeal malignancies and computerized tomography. A correlation of tomographic and histopathologic findings.

We compared the anatomic structures, computerized tomographic (CT) scan images and the histopathologic findings after surgery in 15 patients with laryngeal epidermoid carcinoma. We examined the horizontal whole-mount histologic sections along with the preoperative CT and verified the preoperative impression of the soft tissue changes of preepiglottic space involvement; true cord, false cord and aryepiglottic fold invasion; or subglottic extension in all 15 patients. It was impossible to judge reliably the microscopic invasion of bone or cartilage with this method. Preoperative CT evaluation of carcinoma of the larynx was a reliable method for judging gross tumor size, though decisions regarding conservation surgery cannot be based on CT evaluation alone.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Laryngeal amyloidosis and laryngocele.

Laryngeal amyloidosis and laryngoceles are uncommon. A unique case of both conditions occurring simultaneously is discussed. Preoperative computerized tomographic sections clearly demonstrated both disease processes, their extensiveness, and their intimate relation. These findings are correlated with the endoscopic and surgical findings. Gross and histopathologic specimens give full confirmation of the diagnosis. To our knowledge, this is the first case of laryngocele secondary to amyloidosis.

Amyloidosis↗
PubMedDate not supplied

Mechanisms of pneumothorax following tracheal intubation.

To investigate the mechanism by which pneumothorax may occur as a complication of tracheal intubation, we submitted four cats to tracheotomy and three to tracheal intubation. To simulate the dissection of air along fascial planes following tracheotomy, we placed catheters in either the pretracheal or subcutaneous plane and applied positive pressure to the catheters. The cats undergoing tracheal intubation were ventilated with excessive positive pressure. Computed tomography was used to document the progression of pneumothorax. High positive pressures during mechanical ventilation led to pneumothorax and pneumomediastinum, and the mechanism was primarily the dissection of air along the perivascular sheaths of the pulmonary arteries, presumably due to rupture of perivascular alveoli. Dissection of air along the pretracheal fascia following tracheotomy produced pneumomediastinum but not pneumothorax. This suggests that pneumothorax occurring clinically is more likely a complication of assisted ventilation than a complication of tracheotomy surgery.

Animals↗
PubMedDate not supplied

Otologic complications following temporomandibular joint arthroscopy.

The recent application of arthroscopic surgical techniques to the temporomandibular joint (TMJ) has facilitated the diagnosis and treatment of TMJ disorders. However, as TMJ arthroscopy is performed more frequently, new complications are being recognized. We report three patients who developed severe otologic complications following TMJ arthroscopy. Two sustained complete or severe sensorineural hearing loss and severe vertigo from trauma to the ipsilateral ear. The third patient had complete facial paralysis from trauma to the facial nerve in the middle ear and a conductive hearing loss from incus dislocation. Complete hearing loss and facial paralysis from trauma to the main trunk of the facial nerve have not been reported previously as complications of TMJ arthroscopy.

Adult↗
PubMedDate not supplied

The use of magnetic resonance imaging in the evaluation of retinoblastoma.

We examined a 4-year-old boy who had a painful blind eye, rubeosis iridis, and leukokoria. Ultrasonography and computed tomography (CT) detected intraocular calcification and other features suggestive of retinoblastoma. The CT scan showed extraocular extension along the optic nerve. Intracranial extension of the tumor could not be definitely excluded by CT scan with intrathecal metrizamide infusion. Magnetic resonance imaging (MRI) and CT performed after radiation and chemotherapy were useful in excluding intracranial spread of malignant cells, thereby aiding the selection of a surgical approach to ensure complete removal of the involved portion of the optic nerve.

Child, Preschool↗
PubMedDate not supplied

Progressive hemifacial atrophy (Parry-Romberg disease).

Hemifacial atrophy (Parry-Romberg syndrome) is characterized by slowly progressive atrophy of one side of the face, primarily involving the subcutaneous tissue and fat. The onset is usually in the first two decades. Ophthalmic involvement is common; the most frequent abnormality is progressive endophthalmos with subsequent changes in the palpebral fissure. Pupillary disturbances, heterochromia, uveitis, and restrictive strabismus have also been frequently reported. We describe six cases that manifest a wide spectrum of ocular and systemic findings. They are noteworthy in that all exhibit pigmentary disturbances of the ocular fundus, a finding rarely reported. Another unusual ocular manifestation in one patient was an acquired partial third nerve palsy on the unaffected side.

Adolescent↗
PubMedDate not supplied

Evaluation of the globe using computed tomography and magnetic resonance imaging.

This article is a review of computed tomography (CT) and magnetic resonance imaging (MRI) findings in three groups of pathological conditions of the globe: a) malignant tumors, b) benign tumors and vascular lesions, and c) miscellaneous conditions. MRI technical refinements and the use of gadolinium-DTPA as an enhancement agent provide better anatomic definition of the globe. However, CT remains the method of choice in the investigation of lesions with calcification and bone. In the group of malignant tumors, retinoblastoma, the most common intraocular tumor in childhood, is best diagnosed with CT; for malignant melanoma, the most frequently encountered primary intraocular malignancy in adults, MR is the imaging modality of choice; and for metastatic tumors to the eye, mainly carcinomas, CT and MRI do not show characteristic features.

Carcinoma↗
PubMedDate not supplied

Encephalopathy in AIDS patients: evaluation with MR imaging.

The presence and extent of encephalopathy were evaluated in 47 patients with AIDS or AIDS-related complex (ARC) by the use of MR imaging. Twenty-nine (62%) of the patients showed some form of white matter disease, exhibited as high signal intensity on T2-weighted images. Focal white matter lesions were seen in 23 (49%) of the patients, while a diffuse white matter process was observed in six patients (13%). Of the 29 patients who had white matter disease on MR scans, 17 (36%) had a suggestion of white matter involvement on an initial CT study. Meanwhile, 12 (26%) of the patients had a normal CT scan on the initial examination. MR findings showed predominant disease in the subinsular and peritrigonal white matter areas. Marked cerebral atrophy was observed in 17 (36%) of 47 patients, cerebellar atrophy in 18 (38%), and brainstem atrophy in seven patients (15%). Pathologic findings showed that toxoplasmosis was present in eight patients (17%), and primary CNS lymphoma was present in three patients (6%). Cryptococcal meningitis was noted in two (4%) of the patients at autopsy, and Mycobacterium tuberculosis was seen in one (2%) of the patients at autopsy. MR imaging has been shown to be a valuable technique for the detection of encephalopathy in AIDS patients.

AIDS Dementia Complex↗
PubMedDate not supplied

CT in the evaluation of the orbit and the bony interorbital distance.

The distance between the orbits and their individual dimensions are important in the diagnosis of craniofacial anomalies. Most observers rely on standard radiographs for measuring the bony interorbital distance. Tomography of the skull base and orbital computed tomography (CT) can also be used. This article describes the normal range of the bony interorbital distance and other useful orbital linear and angular measurements as determined from a series of CT scans of the orbits in 400 adults who had CT for other purposes. The normal interorbital distance measured at the posterior border of the frontal processes of the maxilla on nonrotated scans, in the plane of the optic nerve, ranges from 2.29 to 3.21 cm (average, 2.67 cm) in men and 2.29 to 3.20 cm (average, 2.56 cm) in women. The widest interorbital distance lies behind the posterior poles of the globes. This ranges from 3.16 to 4.10 cm (average, 3.37 cm) in men and 2.93 to 3.67 cm (average, 3.20 cm) in women.

Adolescent↗