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Biomedical subjects

M F Piepoli

Publications and source records attributed to M F Piepoli.

25 records · Page 2Linked to original sources
PubMed2000

[New concepts in the interpretation of the cardiovascular and respiratory response to acute physical exercise. Implications in chronic heart failure].

Exercise provides a powerful stress that permits the study of the regulation of the cardiovascular and respiratory systems under rigorously and highly reproducible conditions. In this review the cardiopulmonary adjustments to acute exercise loads and control mechanisms operating in normal subjects have been reviewed. A comparison with the responses of chronic heart failure has been made with the aim of highlighting the origin of reduced exercise tolerance and early occurrence of dyspnea, characteristic features of this syndrome. The clinical and therapeutic implications of cardiopulmonary exercise test are discussed.

Adaptation, Physiological↗
PubMed2000

Emerging concepts in exercise training in chronic heart failure.

There are objective similarities between heart failure and muscular deconditioning. Deficiencies in peripheral blood flow and skeletal muscle function, morphology, metabolism and function are present. The protective effects of physical activity have been elucidated in many recent studies: training improves ventilatory control, metabolism and autonomic nervous system. Exercise training seems to induce its beneficial effects on the skeletal muscle both directly (on function, histological and biochemical characteristics) and indirectly by reducing the activation of the muscle neural afferents (ergoreceptors). On this basis a skeletal muscle origin of symptoms in heart failure has been proposed. The possible metabolic mediators of ergoreceptors are currently being under investigation and they could be a possible target of therapy in heart failure symptoms.

Cardiac Output, Low↗
PubMed1999

The role of oral 1C antiarrhythmic drugs in terminating atrial fibrillation.

Antiarrhythmic drug therapy still remains the mainstay in the management of many supraventricular and ventricular arrhythmias. Several studies have recently pointed out the role of orally administered class 1C drugs in terminating atrial fibrillation. These drugs can play an important role in the ambulatory management of selected patients. The electrophysiologic mechanisms of these antiarrhythmic drugs together with their pharmacologic properties and clinical indications are discussed according to the current literature.

Administration, Oral↗
PubMed1999

Clinical potential of emerging antiarrhythmic agents.

Analyses of randomised clinical trials have suggested that only in selective populations may antiarrhythmic drugs be effective in improving prognosis: therapy of cardiac arrhythmias, in contrast to other cardiovascular pathological conditions, has not been fully successful. The ideal treatment of arrhythmias should be guided by a sound understanding of the relative arrhythmogenic mechanisms and vulnerable parameters of the different arrhythmias. New model agents are pure class III agents, developed to fulfil these ideal characteristics and are now under active investigation (dofetilide, ibutilide, azimilide, ambasilide, E 4031, almokalant, sematilide, RP 58866 and tedisamil).

Animals↗