Biomedical subjects
M F Ramadan
Publications and source records attributed to M F Ramadan.
A prospective randomized trial of suture material in aural wound closure.
The aim of the study was to compare synthetic monofilament suture materials with chromic catgut and silk in aural wound closure. Forty patients undergoing mastoidectomy or tympanoplasty were randomized to closure with either 3o PDS (Polydioxanone) to fascia plus 3o Prolene to skin, or 2o chromic catgut to fascia plus 3o silk to skin. Known or suspected factors affecting wound healing were recorded. Nine patients had post-operative wound infections. The infection rate was significantly lower in wounds closed with PDS and Prolene (chi 2 = 6.05, p less than .05), and in tympanoplasty operations (chi 2 = 4.42, p less than .05). Four patients suffered wound dehiscence, all four had been closed with catgut and silk. No other complication of wound healing was noted in the trial. In conclusion, PDS and Prolene are superior suture materials to catgut and silk in the closure of aural wounds.
A method for preparation of fibrin glue.
Otorhinolaryngological operations would be facilitated by the use of a safe, cheap, surgical adhesive. Though commercial fibrin glue is effective, it is both relatively expensive and, because it is prepared from pooled human blood, there has been concern that it carries the risk of transmitting viral disease, in particular hepatitis and acquired immune deficiency syndrome. We describe a rapid, cheap method of preparing sufficient fibrin glue, of adequate bonding power, from a small quantity of the patient's own blood, and therefore with no risk of contracting viral disease. Our method of preparation of fibrin glue promises to provide a valuable adjunct to otorhinolaryngological surgical practice.
Effect of experimental nasal obstruction on growth of alveolar arch.
Sixty 4-week-old New Zealand albino rabbits, obtained as 20 sets of littermates, were divided into three groups such that one rabbit from each litter appeared in each group. After radiological measurements of cranial dimensions, all animals underwent nasal electrocauterization. Group 1 underwent cauterization but no nasal obstruction was created. Cauterization was done to produce unilateral obstruction in group 2 and bilateral obstruction in group 3. After growth had ceased, the prepared skull of the mature animal was measured to assess the alveolar and cranial dimensions. The alveolar arch in the animals with bilateral obstruction was significantly narrower and shorter than in the control rabbits and in those with unilateral obstruction, but there was no significant difference in the palatal height among the three groups.
Experimental nasal obstruction and changes in the arterial blood gases.
This is a controlled animal experiment in which the effect of chronic nasal obstruction on the arterial blood gases was studied. Sixty female New Zealand Albino rabbits, in groups of 3 litter mates were assigned to 3 groups: control, unilateral nasal obstruction, and bilateral nasal obstruction. Nasal obstruction was produced using coagulating electro-cautery and the values of pO2, pCO2 and pH in the arterial blood were studied. In animals with unilateral nasal obstruction the blood gas values were similar to those in the control group. In animals with bilateral nasal obstruction there was a marked fall in pO2 and a marked increase in pCO2. These changes were statistically significant, but there was no significant change in arterial pH in any of the obstructed groups.
Reconstruction after pharyngolaryngo-oesophagectomy using delto-pectoral flap.
Fifty patients with hypopharyngeal cancer treated with total pharyngolaryngectomy and staged reconstruction using delto-pectoral flaps in the years from 1967-1976 were studied. The main complications were fistulae and stricture formation; these are described. The hospital mortality was low, and postoperative deaths only occurred in previously irradiated patients. The crude 5-year survival was 35%.