PubMed Health⌕ Search

Biomedical subjects

M Fabre-Thorpe

Publications and source records attributed to M Fabre-Thorpe.

At least 19 recordsLinked to original sources
PubMed2001

A limit to the speed of processing in ultra-rapid visual categorization of novel natural scenes.

The processing required to decide whether a briefly flashed natural scene contains an animal can be achieved in 150 msec (Thorpe, Fize, & Marlot, 1996). Here we report that extensive training with a subset of photographs over a 3-week period failed to increase the speed of the processing underlying such Rapid Visual Categorizations: Completely novel scenes could be categorized just as fast as highly familiar ones. Such data imply that the visual system processes new stimuli at a speed and with a number of stages that cannot be compressed. This rapid processing mode was seen with a wide range of visual complex images, challenging the idea that short reaction times can only be seen with simple visual stimuli and implying that highly automatic feed-forward mechanisms underlie a far greater proportion of the sophisticated image analysis needed for everyday vision than is generally assumed.

Adult↗
PubMed2001

Detection of animals in natural images using far peripheral vision.

It is generally believed that the acuity of the peripheral visual field is too poor to allow accurate object recognition and, that to be identified, most objects need to be brought into foveal vision by using saccadic eye movements. However, most measures of form vision in the periphery have been done at eccentricities below 10 degrees and have used relatively artificial stimuli such as letters, digits and compound Gabor patterns. Little is known about how such data would apply in the case of more naturalistic stimuli. Here humans were required to categorize briefly flashed (28 ms) unmasked photographs of natural scenes (39 degrees high, and 26 degrees across) on the basis of whether or not they contained an animal. The photographs appeared randomly in nine locations across virtually the entire extent of the horizontal visual field. Accuracy was 93.3% for central vision and decreased almost linearly with increasing eccentricity (89.8% at 13 degrees, 76.1% at 44.5 degrees and 71.2% at 57.5 degrees ). Even at the most extreme eccentricity, where the images were centred at 70.5 degrees, subjects scored 60.5% correct. No evidence was found for hemispheric specialization. This level of performance was achieved despite the fact that the position of the image was unpredictable, ruling out the use of precued attention to target locations. The results demonstrate that even high-level visual tasks involving object vision can be performed using the relatively coarse information provided by the peripheral retina.

Adult↗
PubMed2000

Brain areas involved in rapid categorization of natural images: an event-related fMRI study.

Event-related fMRI was used to investigate brain activation during a visual go/no-go categorization task based on colored photographs of natural scenes, similar to a previous ERP study by Thorpe et al. (1996, Nature 381: 520-522). Subjects had to press a key when an animal was present in the display. Stimuli were flashed for 33 ms using an intertrial interval of 5 s and a design that carefully balanced targets and distractors in a pseudo-random sequence. Activation produced by targets and distractors was compared with two different techniques, one based on correlations with the stimulation pattern, the other using simple t score statistics to compare selected scans. The contralateral primary motor cortex and the ipsilateral cerebellum were both more active following target trials than following distractors, thus confirming the sensitivity of the method. Differential activity was also seen in the posterior cingulate cortex, the fusiform, and the parahippocampic gyri. Activity in such structures could underlie the differential evoked-potentials reported previously in the same task. Surprisingly, in these visual structures, the signal was stronger following distractor trials than target ones. This result could be due to more prolonged processing on distractor trials. Alternatively, it could be that target detection induces strong activation of a small proportion of neurons, which, because of competitive inhibitory mechanisms, could result in a decrease in activity for the population as a whole. We suggest that this kind of mechanism could also account for the decreases in signal observed in perceptual priming experiments.

Adult↗
PubMed2000

Ultra-rapid categorisation of natural scenes does not rely on colour cues: a study in monkeys and humans.

In a rapid categorisation task, monkeys and humans had to detect a target (animal or food) in briefly flashed (32 ms) and previously unseen natural images. Removing colour cues had very little effect on average performance. Impairments were restricted to a mild accuracy drop (in some human subjects) and a small reaction time mean increase (10-15 ms) observed both in monkeys and humans but only in the detection of food targets. In both tasks, accuracy and latency of the fastest behavioural responses were unaffected, suggesting that such ultra-rapid categorizations could depend on feed-forward processing of early coarse achromatic magnocellular information.

Adult↗
PubMed1999

[Fast visual categorization and speed of processing in migraine].

It has been suggested that the visual cortex of migraine sufferers is hypersensitive. To test this hypothesis, we compared the speed of visual processing in eight migraine patients (including three with aura) and nine controls performing two categorisation tasks of different complexity. In the complex task developed by Thorpe et al. (1996), subjects had to detect the presence of animals in briefly presented photographs (20 ms). The speed of visual processing was measured by the latency of the differential cerebral activity that appears around 150 ms between target and non-target trials. In the simple task, subjects performed a square/circle categorisation. All subjects were faster (445 ms/497 ms) with a higher rate of success (97%/91%) in the simple task. But in both tasks, the behavioural performance and the associated evoked potentials did not show any difference suggesting a cortical hypersensitivity in migraine sufferers.

Adolescent↗
PubMed1998

Rapid categorization of natural images by rhesus monkeys.

Two rhesus macaques were tested on a categorization task in which they had to classify previously unseen photographs flashed for only 80 ms. One monkey was trained to respond to the presence of an animal, the second to the presence of food. Although the monkeys were not quite as accurate as humans tested on the same material, they nevertheless performed this very challenging visual task remarkably well. Furthermore, their reaction times were considerably shorter than even the fastest human subject. Such data, combined with the detailed knowledge of the monkey's visual system, provide a severe challenge to current theories of visual processing. They also argue that this form of rapid visual categorization is fundamentally similar in both monkeys and humans.

Animals↗
PubMed1997

Effect of pairing red nucleus and motor thalamic lesions on reaching toward moving targets in cats.

The small effects of bilateral lesions of motor thalamus on motor control and the transient deficits induced by bilateral kainic red nucleus (RN) lesions have been explained by a parallel competitive role of the cortico- and rubro-spinal pathways. Either pathway can take over motor control if the other is damaged. In this study the effect of bilateral and simultaneous lesions of both RN and motor thalamus was analyzed on cats overtrained to reach toward a moving target. After lesion, accuracy was impaired, movement onset was delayed, and movement execution was perturbed. However, postoperative retraining led to full recovery of the preoperative accuracy level although movement latency remained higher. The relative mildness of the long-lasting deficit after lesioning 2 main motor brain structures underlines the robustness of overlearned movements and widens the idea of parallelism in the motor system to other (subcortical?) pathways.

Animals↗
PubMed1996

Effect of lesioning the nucleus accumbens on attentive preparation and performance of a reaching movement in the cat.

The nucleus accumbens is often considered as an interface between limbic and motor brain structures. In the present experiment, we investigated the effect of a bilateral lesion of the nucleus accumbens on a motor task with attentional constraints. Four male cats were trained to reach for a mobile target that was only accessible for a short period of time and after a variable delay of expectation. They were food-rewarded. Their visuomotor performance was analyzed in speed and accuracy. Their ECoG was recorded to evaluate the occurrence of beta-rhythms that have been shown to be related to a behaviour of focalized attention. After stabilization of their visuomotor performance, all subjects underwent a bilateral neurotoxic lesion of the nucleus accumbens. After lesion, cats were able to maintain their focalized attention while waiting for the target for longer periods of time and the probability of beta-activity increased. Their visuomotor performance showed an improvement both in accuracy and in speed. Moreover, unexpected external stimuli were less efficient in diverting the cats' attention from their task, so that the proportion of unsuccessful trials due to inattention decreased after lesion. The data showed that the lesion induced a focalization of attention resulting in an improvement of motor performance. The role of the nucleus accumbens both in attention control and in modulating motor output is discussed together with the possible cerebral pathway involved.

Animals↗
PubMed1994

Preservation of pointing accuracy toward moving targets after extensive visual cortical ablations in cats.

Impairments in reaching toward stationary and moving targets were studied in cats after restricted or extensive removal of visual cortical areas (areas 17, 18 and 19 and lateral suprasylvian visual areas). Regardless of the extent of the cortical lesion, cats were at first unable to localise and reach for a stationary target whereas they were soon able to detect and accurately point toward a mobile one. Moreover, the onset latency of such movements was dramatically increased. During post-operative re-training, the cats were unable to improve their accuracy scores when reaching towards stationary targets. In contrast, full compensation was observed for the accuracy of reaching movements directed toward moving targets. A partial recovery was observed for movement latency values that progressively decreased but left a permanent 30-40 ms impairment following extensive lesions. The role of extrageniculate messages and alternative routes involving other cortical areas in taking in charge the visuomotor activity is discussed.

Animals↗
PubMed1994

Effect of practice on paw preference in a reaching task in cats.

Paw preference and performance were analyzed in twelve male adult cats during early and late practice of a complex visuo-motor reaching task towards a moving target. A strong bias towards left paw use was seen early in training: 80.7% of the trials being performed with the left paw, and left pawed cats (n = 11) significantly outnumbered right pawed cats (n = 1). After practice, a shift was observed towards right paw use, in that, overall, the proportion of trials executed using the left paw fell to 71.4%. Moreover two of the left pawed cats modified strongly their preference: one shifted to exclusive use of the right paw while the other one became ambidextrous. In non exclusive cats the comparison of visuo-motor scores for left and right paws during late practice showed that the usage of the paw which is both faster and more accurate had increased during training whether or not that paw was initially the preferred one. Furthermore, for cats where no systematic performance advantage was seen (i.e. one paw was faster, the other one more accurate) there was a shift towards ambidextry. As a conclusion, the results confirm a bias towards left paw use in cats performing a complex reaching task, and show that this bias is weakened by practice. The left hemisphere could take more importance when the new visuo-motor activity becomes progressively a well routinized one.

Animals↗
PubMed1993

Interaction of the amygdala with the frontal lobe in reward memory.

Five cynomolgus monkeys (Macaca fascicularis) were assessed for their ability to associate visual stimuli with food reward. They learned a series of new two-choice visual discriminations between coloured patterns displayed on a touch-sensitive monitor screen; the feedback for correct choice was delivery of food. Normal learning in this task is known to be dependent on the amygdala. The monkeys received brain lesions which were designed to disconnect the amygdala from interaction with other brain structures thought to be involved in this memory task. All the monkeys received an amygdalectomy in one hemisphere and lesions in the other hemisphere of some of the projection targets of the amygdala, namely the ventral striatum, the mediodorsal thalamus and the ventromedial prefrontal cortex. The rate of learning new problems was assessed before and after each operation. Disconnection of the amygdala from the ventral striatum was without effect on learning rate. An earlier study had shown that disconnection of the amygdala from either the mediodorsal thalamus or the ventromedial prefrontal cortex produced only a mild impairment, significantly less severe than that produced by bilateral lesions of any of these three structures. The present results show, however, that disconnection of the amygdala from both the mediodorsal thalamus and the ventromedial prefrontal cortex in the same animal, by crossed unilateral lesions of the amygdala in one hemisphere and of both the mediodorsal thalamus and the ventromedial prefrontal cortex in the other hemisphere, produces an impairment as severe as that which follows bilateral lesions of any of these three structures.(ABSTRACT TRUNCATED AT 250 WORDS)

Amygdala↗
PubMed1993

Laterality in cats: paw preference and performance in a visuomotor activity.

Laterality in paw use was investigated over a period of 6 years in 44 domestic cats trained to perform a reaching movement toward a moving spot of light. Both paw preference and paw performance were recorded. At a 50 percent criterion, no significant paw preference was found at the level of the group. When a 90 percent criterion was considered, 23 subjects had a significant preference for one paw. Among these strongly lateralized animals, there were more left- (N = 17) than right-pawed (N = 6) cats. The analysis of visuo-motor performances included reaction time, movement time, and reaching accuracy. Lateralized cats had a faster reaction time than nonlateralized cats. The more-used paw had a shorter reaction time, a shorter movement time, and was also more accurate than the less-used paw. Thus, the findings demonstrate a functional advantage of being lateralized. Moreover, the results confirm the existence of an asymmetry of paw preference in cats and show a consistent relation between paw preference and performance.

Animals↗
PubMed1991

Effects of tianeptine on the performance of a reaching movement in the cat.

Unlike other antidepressant drugs, tianeptine, when administered to cats at doses ranging from 1.2 to 5 mg/kg, produces an increase in arousal associated with longer sequences of immobile attentiveness. The present study analyses tianeptine-induced effects on visuomotor performance. Cats were trained to perform a pointing movement towards a randomly moving spot of light. Following tianeptine treatment (5 mg/kg), visuomotor performance was totally disrupted. When 2.5 mg/kg tianeptine was used, the accuracy of performance was unaffected, whereas the latency of movement onset was considerably and consistently increased. On a number of occasions the movement took also longer to perform. Following lower doses (0.6-1.2 mg/kg), performance was rarely impaired; in contrast, an improvement of visuo-motor scores was observed. This improvement was mostly characterized by an increased accuracy and could be associated with shorter latencies of movement onset or shorter movement times. Desipramine, another antidepressant drug having few sedative effects, induced a clear delay of movement onset when first administered. Further injections did not produce any changes in the visuo-motor performance. These results are discussed in relation with other effects of tianeptine, in particular its facilitatory effect on attentional processes.

Animals↗
PubMed1991

Visuomotor relearning after brain damage crucially depends on the integrity of the ventrolateral thalamic nucleus.

The role of the ventrolateral thalamic nucleus (VL) has been analyzed in the phase of motor recovery that takes place when the execution of a previously learned movement has been perturbed by damage to another brain area. Cats were trained to perform a reaching movement toward a moving target-spot; they underwent bilateral brain lesions after performance had stabilized. A VL lesion induced a very transient increase of reaction time. The lesion of the main thalamic relay of the visual extrageniculate pathway (LP) severely disrupted accuracy and reaction time but was followed by full recovery. When both lesions were performed together, the deficits were similar to those induced by LP lesion alone, although they were more pronounced. However, the functional compensation was incomplete, and furthermore, the recovery of accuracy crucially depended on regular testing. These results support the involvement of VL in motor learning or relearning.

Animals↗
PubMed1991

[Lateralization in cats in a pointing task of the anterior limb towards a moving target].

In a group of 44 cats overtrained on a task where they had to reach for a moving target, paw performance and paw preference were investigated. More than half of the cats (n = 23) were strongly lateralized in that they used one of their paws to perform more than 90% of the reaching attempts. Among these lateralized cats, left-pawed ones (n = 17) significantly exceeded right pawed-animals (n = 6). Investigating both the accuracy and speed scores, the comparison between lateralized and non-lateralized cats (using a criterion of 90% lateralization) showed that although the accuracy scores did not differ, lateralized cats were significantly quicker to trigger their movement. No difference was found concerning the movement time. For the whole group of 44 cats the comparison between the performance levels obtained with their two forepaws showed that the more frequently used paw was significantly more accurate and faster to trigger and to execute the movement than the less used paw. This study shows that, in pointing towards a moving target, cats display an asymmetry in paw preference that is associated with a performance asymmetry.

Animals↗
PubMed1990

Long-term effects of dark rearing on a visually guided reaching movement in cats.

The existence of long-term effects of dark-rearing on visuo-motor coordination is still controversial. In this study 2 dark-reared (DR) cats were trained, after 5-6 years of recovery, to perform a reaching movement towards a stationary or a moving target. The accuracy, and the reaction and movement times were evaluated. The scores obtained by the DR cats were compared to those of normal subjects after a similar period of training. The results showed that while the accuracy of DR cats was not impaired, the performance of their reaching movements was slower than normal and its triggering was delayed. These data are discussed with regards to electrophysiological and behavioural data obtained on analogous DR cats after long-term recovery.

Animals↗
PubMed1990

Visual 'cortical-recipient' and 'tectal-recipient' pontine zones play distinct roles in cat visuomotor performance.

In order to test the hypothesis that visual information reaching the cerebellum through the pontine nuclei is involved in the control of visually guided movements, the effects of bilateral kainic acid pontine lesions have been analysed in cats performing a reaching movement towards a spot of light that was either stationary or moving. In 4 cats, the lesion was restricted either to the ventromedian region (cortical-recipient zone) or to the dorsolateral nucleus (tectal-recipient zone) of the pons. A major and persistent impairment was seen when the cerebellum was deprived of the pontine information influenced by the colliculus. While cats displayed no impairment when reaching towards a stationary target, they exhibited a strong accuracy deficit associated with an increased reaction time when reaching towards a moving target. In contrast, lesioning the pontine zone influenced by the visual cortex induced a transient accuracy deficit with moving targets and a transient delay in movement onset whatever the mode of target presentation. These results emphasise the involvement of visual pontine regions in the guidance of movements; they also confirm previous results showing that tectal visual information plays a more important role than that originating in the visual cortex when movements are directed towards moving targets.

Animals↗