Biomedical subjects

M Fahle

Publications and source records attributed to M Fahle.

At least 19 recordsLinked to original sources

PubMed2006

[Colour vision and acquired colour vision disturbances. Part I: basic aspects].

Colour vision is the most sensitive sensory ability of the human eye, making it possible to distinguish several million nuances of colour. The physiology of colour vision has meanwhile been researched in depth, including the genetic and biochemical principles. This knowledge has facilitated a better understanding of the results of clinical tests on colour vision. These clinical tests provide useful information on the aetiology of very different clinical pictures in ophthalmology and as such are important for the diagnosis of these diseases. Acquired colour vision deficiencies in patients with systemic vascular disease are early signs of dysfunctional microcirculation and play a role in the early diagnostic work-up. Part I of this review summarizes the basic principles of colour vision and its disturbances. Congenital and acquired colour vision disturbances are distinguished. The second part then describes the most commonly employed examination procedures to assess colour vision.

Color Perception↗

PubMed2004

[Central vision].

The clinical assessment of vision by means of optotypes does by no means test just two-point resolution, since a correct naming of the letters or digits requires a preceding visual object recognition. Cortical lesions can massively deteriorate vision up to a "Seelenblindheit" in spite of intact optics and retina. There are different processing levels involved in the analysis which can be individually defective, leading to disorders from visual indiscrimination to agnosia or anomia.

Agnosia↗

PubMed2003

Grasp effects of the Ebbinghaus illusion: obstacle avoidance is not the explanation.

The perception-versus-action hypothesis states that visual information is processed in two different streams, one for visual awareness (or perception) and one for motor performance. Previous reports that the Ebbinghaus illusion deceives perception but not grasping seemed to indicate that this dichotomy between perception and action was fundamental enough to be reflected in the overt behavior of non-neurological, healthy humans. Contrary to this view we show that the Ebbinghaus illusion affects grasping to the same extent as perception. We also show that the grasp effects cannot be accounted for by non-perceptual obstacle avoidance mechanisms as has recently been suggested. Instead, even subtle variations of the Ebbinghaus illusion affect grasping in the same way as they affect perception. Our results suggest that the same signals are responsible for the perceptual effects and for the motor effects of the Ebbinghaus illusion. This casts doubt on one line of evidence, which used to strongly favor the perception-versus-action hypothesis.

Adolescent↗

PubMed2003

Feature-specific electrophysiological correlates of texture segregation.

Discrimination between a figure and its surround is an important first step of pattern recognition. This discrimination usually relies, as a first step, on the detection of borders between a figure and its surround, for example based on spatial gradients in luminance, colour, or texture. There is evidence that neurones in the visual cortex are specifically activated by segregation between textures, but the relation between segregation based on different types of features such as colour, luminance, and motion is unclear. Evoked EEG potentials specific to texture segregation were investigated in 17 observers in two separate experiments and by means of functional magnetic resonance imaging in a separate study (Fahle et al., in preparation). Differences in either luminance, colour, line orientation, motion, or stereoscopic depth defined a checkerboard pattern. Patterns defined by each of these features elicited segregation-specific potentials. In contrast to earlier reports (Vision Research 37 (1997) 1409), however, we find pronounced differences between the segregation-specific potentials evoked through different features, especially regarding their peak latencies. The topographical distribution of the activity evoked reveals different polarities and partly specific locations for different stimulus features, indicating the existence of different processors for texture segregation based on different features.

Adult↗

PubMed2001

Perceptual deformation induced by visual motion.

The perceived position of a moving object can be misleading because the object has advanced while its previous retinal image has been transmitted through the visual stream, leading to a mismatch between actual location and its neural representation. It has been suggested that the human visual system compensates for neural processing delays to retrieve instantaneous position. However, such a mechanism would require a precise measure of the actual delay in order to provide a reliable position estimate. A novel illusory deformation of moving contours demonstrates that humans misjudge the spatial relationship between parts of coherently moving targets, and therefore do not perfectly account for neural delays. The size of this deformation increases with growing speed. In some subjects this illusion can be reversed by varying the luminance of individual dots; a manipulation that affects the neural delays. Our experiments agree with other evidence that the capacity of the visual system to compensate for processing delays is limited.

Decision Making↗

PubMed2001

Spatial aspects of object formation revealed by a new illusion, shine-through.

When a vernier stimulus is presented for a short time and followed by a grating comprising five straight lines, the vernier remains invisible but may bequeath its offset to the grating (feature inheritance). For more than seven grating elements, the vernier is rendered visible as a shine-through element. However, shine-through depends strongly on the spatio-temporal layout of the grating. Here, we show that spatially inhomogeneous gratings diminish shine-through and vernier discrimination. Even subtle deviations, in the range of a few minutes of arc, matter. However, longer presentation times of the vernier regenerate shine-through. Feature inheritance and shine-through may become a useful tool in investigating such different topics as time course of information processing, feature binding, attention, and masking.

Adult↗

PubMed2001

Shine-through: temporal aspects.

If a vernier stimulus precedes a grating for a very short time, the vernier either remains invisible, but may bequeath some of its properties to the grating (feature inheritance), or might shine through keeping its features - depending on the number of grating elements [Herzog, M. H. & Koch, C., 2001. Seeing properties of an invisible element: feature inheritance and shine-through. Proceedings of the National Academy of Science USA 98, 4271-4275]. Feature inheritance and shine-through represent two different states of feature binding [Herzog, M. H., Koch, C., & Fahle, M., Switching binding states. Visual Cognition (in press)], whereas shine-through depends in subtle ways on the spatial layout of the grating [Herzog, M. H., Fahle, M., & Koch, C., (2001). Spatial aspects of object formation revealed by a new illusion, shine-through Vision Research]. Here, we show that also temporal parameters of the grating influence shine-through. For example, a delayed presentation of certain grating elements can deteriorate performance dramatically.

Afterimage↗

PubMed2001

Discriminating contrast discontinuities: asymmetries, dipper functions, and perceptual learning.

In a visual search task, a target has to be found among distractors. For two given elements A and B, the search difficulty can depend on which of the two elements is defined as the target, a phenomenon called search asymmetry. Here, we study to what degree an element's ability to 'win' in a search asymmetry depends on its absolute contrast (first-stage signal) and to what degree it depends on its contrast difference from the background (second-stage signal). One quadrant contained a target texture (2 x 2 Gabor patches of contrast c(tg)), and the other three quadrants contained distractor textures (2 x 2 Gabor patches of contrast c(dt)). These four 'foreground textures' were embedded in a background texture consisting of patches with contrast c(bg). The task was to identify which quadrant contained the target. Quadrants are referred to as increments (foreground contrast c(fg)>c(bg)), or decrements (c(fg)<c(bg)). We found that the second-stage signal determines which element wins the performance asymmetry, i.e. it is easier to find strong increments (decrements) among weak increments (decrements) than vice versa. A comparison of our data with the prediction of the independent-processing model [Vision Res. 40 (2000) 2677] shows that the observed performance asymmetries are in general too large to be attributed to noise differences alone. Rather, asymmetries might reflect a global competition between salient elements. Moreover, performance asymmetries can reverse during practice. We characterize a dipper-shaped nonlinearity on the second stage: discrimination of increment (decrement) signals x and x+Delta x first improves for increasing x, and then deteriorates.

Contrast Sensitivity↗

PubMed2001

Perceptual learning: psychophysical thresholds and electrical brain topography.

We studied perceptual learning by determining psychophysical discrimination thresholds for visual hyper acuity targets (vernier stimuli) as a function of stimulus orientation. One aim was to relate perceptual improvements to changes of electrophysiological activity of the human brain. A group of 43 healthy adults participated in a psychophysical experiment where vernier thresholds for vertical and horizontal vernier targets were compared. In 16 subjects thresholds were measured for each orientation twice at an interval of 25 min. Between threshold estimations, evoked brain activity was recorded from 30 electrodes over the occipital brain areas while the subjects observed appearance and disappearance of supra-threshold vernier offsets. Mean evoked potentials were computed for the first and second 600 stimulus presentations, and the scalp topography of electrical brain activity was analyzed. Vertically oriented stimuli yielded significantly better performance than horizontal targets, and thresholds were significantly lower in the second half of the experiment, i.e. after prolonged viewing of stimuli. The improvements in discrimination performance were specific for stimulus orientation and did not generalize. Learning effects were also observed with electrical brain activity, and field strength of the potentials increased significantly as a function of time. Scalp topography of the evoked components was significantly affected indicating a shift of activation between different neuronal elements induced by perceptual learning.

Adult↗

PubMed2001

Purely temporal figure-ground segregation.

Visual figure-ground segregation is achieved by exploiting differences in features such as luminance, colour, motion or presentation time between a figure and its surround. Here we determine the shortest delay times required for figure-ground segregation based on purely temporal features. Previous studies usually employed stimulus onset asynchronies between figure- and ground-containing possible artefacts based on apparent motion cues or on luminance differences. Our stimuli systematically avoid these artefacts by constantly showing 20 x 20 'colons' that flip by 90 degrees around their midpoints at constant time intervals. Colons constituting the background flip in-phase whereas those constituting the target flip with a phase delay. We tested the impact of frequency modulation and phase reduction on target detection. Younger subjects performed well above chance even at temporal delays as short as 13 ms, whilst older subjects required up to three times longer delays in some conditions. Figure-ground segregation can rely on purely temporal delays down to around 10 ms even in the absence of luminance and motion artefacts, indicating a temporal precision of cortical information processing almost an order of magnitude lower than the one required for some models of feature binding in the visual cortex [e.g. Singer, W. (1999), Curr. Opin. Neurobiol., 9, 189-194]. Hence, in our experiment, observers are unable to use temporal stimulus features with the precision required for these models.

Adolescent↗

PubMed2001

Spatiotemporal interpolation and quality of apparent motion.

We investigate the conditions under which stimuli in apparent (sampled) motion are indistinguishable from those in smooth motion and compare this discrimination with the precision achieved by the visual system in interpolating apparent motion. In an initial experiment, observers were required to discriminate smooth from apparent motion, at variable step sizes, contrasts, velocities, and stimulus types (broadband line or bar stimuli and grating patches of different spatial frequency). Thresholds for discriminating smooth from sampled motion were approximately 40 arc min under optimal conditions, corresponding to the diameter of foveal photoreceptors. The tolerated step size between stations increased with velocity, more so for low- than for high-spatial-frequency stimuli. Tolerated step size decreased with presentation duration and with stimulus contrast. A separate experiment examined precision of interpolation. Vernier offsets were produced through temporal delays along the trajectory of an apparent motion, and thresholds for the discrimination of direction of offset were measured as a function of speed of motion and of distance between stations of apparent motion. Perfect interpolation was achieved for distances between stations of approximately 2 arc min. A model based on spatiotemporal filtering at an early stage of processing accounts well for the results of both types of experiments.

Adult↗

PubMed2001

Effects of visual illusions on grasping.

In 2 experiments, the Muller-Lyer illusion (F. C. Muller-Lyer, 1889; N = 16) and the parallel-lines illusion (W. Wundt, 1898; N = 26) clearly affected maximum preshape aperture in grasping (both ps < .001). The grasping effects were similar but not perfectly equal to the perceptual effects. Control experiments show that these differences can be attributed to problems in matching the perceptual task and the grasping task. A model is described stating the assumptions that are needed to compare the grasping effects and the perceptual effects of visual illusions. Further studies on the relationship between perception and grasping are reviewed. These studies provide no clear evidence for a dissociation between perception and grasping and therefore do not support the action versus perception hypothesis (A. D. Milner & M. A. Goodale, 1995).

Adolescent↗

PubMed2000

Motion-stereo mechanisms sensitive to inter-ocular phase.

We measured depth from interocular delay (The Pulfrich effect) using a dynamic random-dot pattern, consisting of a spatially-random noise field, the individual elements of which were sinusoidally-modulated in luminance over time. When an interocular phase difference in the flicker was introduced the display appeared to rotate in depth around a vertical axis like a transparent textured cylinder. The threshold phase lag was in the region of 5-10 degrees in different observers, which translated into a non-constant, decreasing interocular delay (ms) as the flicker frequency was increased. We conclude that phase, not delay, is the critical parameter in determining the detection of depth. Threshold signal/noise ratios were measured at different delays to determine the optimum phase difference, which was found to be in the region 60-90 degrees. However, delays centred around 180 degrees were less detectable than those around zero, ruling out a quadrature input to the stereo-motion mechanisms. We show that depth-from-phase is a natural consequence of paired monocularly motion-direction sensitive neurones. Complex energy-detecting neurones are not required to explain the findings.

Fourier Analysis↗

PubMed2000

Correlates of figure-ground segregation in fMRI.

We investigated which correlates of figure-ground-segregation can be detected by means of functional magnetic resonance imaging (fMRI). Five subjects were scanned with a Siemens Vision 1.5 T system. Motion, colour, and luminance-defined checkerboards were presented with alternating control conditions containing one of the two features of the checkerboard. We find a segregation-specific activation in V1 for all subjects and all stimuli and conclude that neural mechanisms exist as early as in the primary visual cortex that are sensitive to figure-ground segregation.

Adult↗

PubMed2000

Performance asymmetries in visual search demonstrate failure of independent-processing models.

We report psychophysical data from orientation-popout experiments that are inconsistent with a rather general decision model. Stimuli consisted of 121 line segments arranged on an 11x11 grid. There were two tasks: in the 1-Singleton Task all lines except one had the same orientation, and observers had to report which quadrant contained the singleton. In the 3-Singleton Task three quadrants contained orientation singletons and observers had to identify the quadrant without singleton. These tasks can be viewed as asymmetric search tasks, in which either a singleton-quadrant has to be found among three homogeneous quadrants, or a homogeneous quadrant has to be found among three singleton-quadrants. Using tools from signal-detection theory we show that the large performance asymmetries between 1-Singleton and 3-Singleton Tasks are inconsistent with any model that makes two (very basic and common) assumptions: (1) independent processing of the four quadrants and (2) an ideal-observer decision. We conclude that at least one of the two assumptions is inadequate. As a plausible reason for the model failure we suggest a global competition between salient elements that reduces popout strength when more than one singleton is present.

Humans↗

PubMed2000

Parallel detection of orientation differences in the presence of orientation gradients.

We measured thresholds and reaction times for detecting a target, defined by orientation contrast, as a function of the number of elements displayed simultaneously and of the linear orientation gradient present in the display. This test served to evaluate how well the human visual system is able to ignore smooth gradients in orientation - similar to what it does with gradients of luminance or wavelength. Smooth orientation gradients are common in natural environments as opposed to the usual laboratory (search) experiments. It turns out that targets defined by a discontinuity in the transition between line orientations can be processed in parallel, i. e. that 'search' times increase by between 0.5 and 6 ms, on average, per additional element displayed, irrespective of the number of elements. But thresholds of orientation difference for the detection of the target increase linearly with the orientation gradient present in the display, and tend to increase more strongly for small gradients, indicating a special bonus for (near) collinearity. The averaged data follow a Weber-law type while this is not true for the individual observers' data. These results show that the visual system is indeed able to detect targets based on orientation contrast, rather than on absolute orientation [cf. Nothdurft (1985). Vision Research, 25, 551-560], but that the orientation gradient cannot be ignored.

Computer Graphics↗

PubMed2000

Summation of texture segregation across orientation and spatial frequency: electrophysiological and psychophysical findings.

Objects are usually segregated from ground by several visual dimensions. We studied texture segregation in checkerboards defined by gradients in spatial frequency, orientation or both frequency and orientation, using Gabor-filtered noise patterns. Saliency was measured electrophysiologically using the visual evoked potential (VEP) associated with texture segregation ('tsVEP') (an associated component in the visual evoked potential), and psychophysically by a 2AFC task. Spatial frequency and orientation stimuli evoked percepts of texture segregation and tsVEPs in all 11 subjects. The tsVEPs to combined stimuli were larger than those to each dimension alone, but smaller (74%) than the algebraic sum of tsVEPs to both individual dimensions. Psychophysical detection rates differed significantly between all conditions (P < 0.001), with highest rates for the combined stimuli. The findings suggest that segregation based on a combination of 'orientation' and 'spatial frequency' is more salient than that based on either of these alone. The significant deviation from full additivity in the tsVEPs suggests that simultaneous contrasts in spatial frequency and orientation have a common processing stage.

Evoked Potentials, Visual↗

PubMed2000

Grasping visual illusions: no evidence for a dissociation between perception and action.

Neuropsychological studies prompted the theory that the primate visual system might be organized into two parallel pathways, one for conscious perception and one for guiding action. Supporting evidence in healthy subjects seemed to come from a dissociation in visual illusions: In previous studies, the Ebbinghaus (or Titchener) illusion deceived perceptual judgments of size, but only marginally influenced the size estimates used in grasping. Contrary to those results, the findings from the present study show that there is no difference in the sizes of the perceptual and grasp illusions if the perceptual and grasping tasks are appropriately matched. We show that the differences found previously can be accounted for by a hitherto unknown, nonadditive effect in the illusion. We conclude that the illusion does not provide evidence for the existence of two distinct pathways for perception and action in the visual system.

Consciousness↗