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M Falkenberg

Publications and source records attributed to M Falkenberg.

46 records · Page 3Linked to original sources
PubMed1987

Value of thyroid follow-up registers.

In this study from a county in southern Sweden 269 of 271 patients (99.3%) treated with radioiodine for hyperthyroidism over a two-year period were followed up five years later. The routine procedures at hospital clinics and primary health care centres were studied. A high number of toxic multinodular goitre (n = 113; 42.0%) and toxic adenoma (n = 76; 28.3%) emerged, 80 patients (29.7%) had toxic diffuse goitre (Graves's disease). During the five-year follow-up the cumulative incidence of hypothyroidism in the various goitre groups was 10.7%, 23.9%, and 57.5% respectively. Altogether 76 patients (28.3%) were diagnosed hypothyroid. Nine patients were lost to regular follow-up; elevated TSH and low or normal T4-concentrations were found in two of them. We propose a register system to enable detection of thyroid dysfunction after radioiodine treatment and other thyroid patients in primary health care.

Adult↗
PubMed1985

Hyperthyroidism in elderly women. Registered and detected by screening in a primary health care district.

A laboratory screening for thyroid disease was performed among women older than 60 years in a primary health care district in a goiter region. The screening was combined with a questionnaire regarding previously treated thyroid disorder. A total of 1442 women i.e., 97.3% of the population studied were investigated. Through the laboratory screening we found 28 women (1.9%) with hyperthyroidism and they were successfully treated. Through the questionnaire 50 women (3.4%) were identified with previously treated hyperthyroidism--of these 42 were diagnosed after the age of 60. We suggest that physicians should maintain increased awareness to order thyroid laboratory tests (e.g. free T4 index, free T3 index) in women older than 60 years of age because atypical symptoms and signs are often difficult to separate from the age process per se.

Aged↗
PubMed1983

Screening of an elderly female population for hypo- and hyperthyroidism by use of a thyroid hormone panel.

The elderly female population living in a rural primary health care district in the south of Sweden was screened for hypo- and hyperthyroidism. A total of 1 442 (97.3%) of the 1 482 women 60 years of age or older attended the study. By use of a computer-evaluated thyroid hormone panel, 178 women (12.3%) were identified as probably abnormal. Among them, 8 women (0.55% of total) with previously unknown thyroid disease were detected as overtly hypothyroid. If also 13 women with spontaneous subclinical hypothyroidism were included, the prevalence of earlier unknown hypothyroidism was 21/1 442 (1.5%). The number of subjects with hyperthyroidism discovered by screening was 28/1 442 (1.9%). Although much remains to be elucidated regarding medical, social and economic factors, the high figures obtained for newly discovered abnormal thyroid function suggest that screening for hyper- and hypothyroidism may be worthwhile in such an elderly female population.

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PubMed1975

Abdominal aortic aneurysm. An interhospital study of 171 surgically treated patients.

A retrospective interhospital study of 171 surgically treated patients with atherosclerotic abdominal aortic aneurysm is presented (Orebro and Göteborg). Elective resection of the aneurysm was performed in 94 of the patients and emergency resection because of rupture or suspected rupture of the aneurysm in 77 cases. The mortality within the first postoperative month was 16% in the electively operated patients and 49% in the emergency operated patients. During the last 3 years, the mortality rate among electively operated patients was considerably lower (10%). The five-year survival rate was more than 50% in the electively operated patients. The main difference in long-term survival rate between emergency and electively operated patients was dependent on the primary mortality. The cause of late death was usually not related to the operation of the aneurysm, but to other manifestations of generalized atherosclerotic disease. The results seem to justify the conclusion that atherosclerotic abdominal aortic aneurysm should be resected irrespective of size and symptoms, unless the patient has symptoms of severe arterial hypertension and/or generalized atherosclerosis.

Adult↗
PubMedDate not supplied

Urokinase plasminogen activator colocalizes with CD25+ cells in atherosclerotic vessels.

Proteolytic activity in vascular tissue is necessary for cellular migration, remodelling of extracellular matrix and the development of atherosclerotic lesions. Inflammatory cells, mainly macrophages, are numerous in atherosclerotic plaques and may synthesize and secrete proteolytic enzymes. The principal activator of plasminogen in tissues is urokinase plasminogen activator (u-PA). To determine if an activated phenotype of inflammatory cells colocalizes with local expression of u-PA in atherosclerotic vessels, vascular biopsies from 15 patients with peripheral atherosclerotic disease were analyzed by immunohistochemistry on consecutive sections. Anti-CD68 antibodies were used as markers for macrophages and were positive in 14/15 specimens. Anti-CD25 (interleukin-2 receptor-alpha) antibodies were used to identify inflammatory cells with an activated phenotype and were positive in 9/14 CD68+ specimens. The same 9 specimens were positive for u-PA. A positive reaction for u-PA was found only in specimens with CD25+ cells. Specimens with positive reactions for all three antibodies were further analyzed with computer-assisted image analysis. The colocalization with u-PA was higher for CD25 compared to CD68 in all specimens. Mean percentage of the u-PA-positive area in regions positive for cellular markers was 52% (SEM 6%) for CD25 and 19% (SEM 5%) for CD68 (p < 0.01). The results indicated that the activation of macrophages in atherosclerotic vessels may modulate local proteolysis and be of importance in plaque development and stability.

Aged↗