Biomedical subjects

M Fartasch

Publications and source records attributed to M Fartasch.

75 records · Page 5Linked to original sources

PubMedDate not supplied

Papular palmoplantar hyperkeratosis following chronic medical exposure to arsenic: human papillomavirus as a co-factor in the pathogenesis of arsenical keratosis?

This study presents the case of a 38-year-old patient from Pakistan with vitiligo, who developed multiple verrucous papules on the palms and soles several years after receiving "herbal treatment" from a travelling Indian doctor for a period of 12 months. Histopathological examination showed changes consistent with the diagnosis of arsenical keratosis. Molecularbiological examination of a skin biopsy detected an atypical human papillomavirus. This observation supports the concept of human papillomavirus as a co-factor in the pathogenesis of premalignant arsenic-induced skin tumours.

Adult↗

PubMedDate not supplied

[Ultrastructural studies on obstructive palatal sialadenitis in denture wearers].

The ultrastructural phenomena of obstructive palatal sialadenitis were studied in 7 denture wearers versus 3 non-denture wearers as control. Apart from mucositis severe stagnation of salivary flow in the excretory ducts was observed in patients with dentures with short periods of service. In contrast to the control group there were mucous droplets after exocytosis of the acinus cells that remained intact even in the lumina of the distal excretory ducts. Desquamation of the duct and acinus cells results in a change in the organic components of the secretory mucus. The periductal infiltrate consisted mainly of plasma cells and lymphocytes, whereas neutrophils or macrophages were not observed. Ultrastructurally there was no evidence of an ascending microbial infection of the ducts. Probably, infections do not play an important role in the pathogenesis of obstructive palatal sialadenitis.

Adult↗

PubMedDate not supplied

[Occurrence of contact allergies in atopic eczema. Relation to simultaneously detected atopic markers].

In a prospective study the risk of delayed-type hypersensitivity was investigated in 65 patients with atopic eczema (AE) and a noneczematous control group (n = 78) largely similar in age and occupational distribution. The diagnosis of AE was established according to the diagnostic criteria of Hanifin and Rajka. Patch tests were performed using the European standard series. There was no significant difference in the occurrence of contact sensitivity. Atopics showed a significantly higher incidence of reactions to nickel (atopics 28%/controls 6%/p less than 0.01), especially in females (females 29%/9%, p less than 0.05). Sensitivity to nickel could be regarded as a further minor atopic criteria. Patients with AE and simultaneously delayed type hypersensitivity showed significantly higher IgE levels (IgE means = 733 U/ml), than atopics without contact sensitivities (IgE means = 290 U/ml), but no differences in the occurrence of any major or minor criteria.

Adult↗