Biomedical subjects

M Fasola

Publications and source records attributed to M Fasola.

27 records · Page 2Linked to original sources

PubMed1993

Cesarean section: an economic appraisal of infectious complications.

From March 1991 to April 1992, in the Dept. of Obstetrics and Gynecology, University of Pavia-Varese, 107 out of 115 consecutive patients submitted to cesarean section were evaluated for the clinical and economic evaluation of infectious complications. On the grounds of our previous experience we distinguished two groups: a high infection risk group (50 pts), because of labor and/or rupture of membranes, HIV+, diabetes; and a low infection risk group (57 pts). Our findings support the choice of these selective criteria both for the infectious event or for the use, and thence for the costs, of antibiotic treatment. In fact, based on this experience we believe that in cesarean sections with high infection risk AP is always recommended whereas in the low risk ones AP should not exceed L. 10.095 to be cost-effective.

Adult↗

PubMed1992

[Evaluation of a new method for cervical cytology].

An adequate sample is the most important factor for successful cervical cytology. In this study a conventional method is compared to a new method of biopsy in a group of 40 patients undergoing tests in June 1991. A quantitative and qualitative evaluation of esocervical and endocervical cells was made; similar percentages were obtained for floor cells using both using systems, whereas higher percentage values (82.5% vs 67.5%) were obtained for cylindrical cells using the new method. Compared to the conventional method the new method also possessed an inadequacy rate of below 50% in post-menopausal patients. Therefore, although the new method is similar to the conventional one in terms of quality, it is thought to be more appropriate due to the greater number of endocervical cells collected, especially in post-menopausal patients.

Adult↗

PubMed1991

Adenocarcinoma of the uterine cervix.

From 1970 to 1989, 39 patients with cervical adenocarcinoma (9.3% of all cervical cancers) were treated in the Department of Gynecology - University of Pavia. Adenocarcinoma seemed to be a disease epidemiologically different from epidermoid carcinoma. Treatment included radical hysterectomy, radiotherapy, radical hysterectomy and radiotherapy. In stage I disease survival was not significantly influenced by treatment modality. However in young patients without risk factors surgery seemed to obtain the best results; in high risk patients adjuvant radiotherapy did not apparently improve survival. Prognosis for adenocarcinoma seemed to be worse than for its squamous counterpart. The main prognostic factors were grading and lymph node status. Relapse occurred also a long time after treatment. In 2 cases we observed Cervical Intraepithelial Neoplasia grade 3 (CIN 3) in association with adenocarcinoma.

Adenocarcinoma↗

PubMed1990

Diagnostic alternatives to second look in ovarian cancer.

The accuracy of the markers CA 125, CA 15-3, CA 50 serum levels and the CT findings as alternative monitoring techniques to second look has been evaluated in 25 patients. The negative predictive value for the CA 125 was of 55% and its sensibility seems not to be increased by the association of the other markers. For the CT findings we report a diagnostic accuracy of 76%.

Adult↗

PubMed1987

Trends of organochlorine residues in eggs of birds from Italy, 1977 to 1985.

All the eggs, collected in Italy in 1982 and 1983, of two species of passerine birds, three gulls, four terns and the night heron, contained DDE and, with lower frequencies, other organochlorine contaminants. Organochlorines were more concentrated in the species of higher trophic level. DDE contamination showed a decreasing trend from 1978 to 1985 in one passerine, two terns and in the heron. After 1980-1982, the level of contamination was below the critical threshold beyond which reproduction is affected, eggshell thickness was only slightly or not reduced; therefore, the current impact of organochlorines on these birds is probably negligible. Detrimental effects may have occurred during the 1970s, when some of the eggs were contaminated beyond the critical threshold.

Journal Article↗

PubMedDate not supplied

Residues of organochlorinated pesticides in eggs of water birds from Tai Lake in China.

The levels of organochlorine compounds in eggs of water birds from the colony on Tai Lake in China were studied. The eggs were collected in 2000 and belonged to the following species: 65 samples of black-crowned night heron (Nycticorax nycticorax), 36 samples of little egret (Egretta garzetta), 26 samples of cattle egret (Bubulcus ibis) from 13 clutches and 43 samples of Chinese pond heron (Ardeola bacchus) from 17 clutches. Dichlorodiphenyltrichloroethane (DDT) and its derivates (DDE and DDD), hexachlorocyclohexane (HCH) and its isomers (alpha-HCH, beta-HCH, gamma-HCH, delta-HCH), heptachlor, heptachlor epoxide, aldrin, dieldrin, endrin, endrin aldehyde, alpha-endosulfan, beta-endosulfan, and endosulfan sulfate were determined in the laboratory by gas chromatography. The data showed that DDE had the highest levels in all the samples, followed by beta-HCH. The mean levels of DDE among the water bird species were in the order as follows: black-crowned night heron (5464.26 ng/g, dry weight) > Chinese pond heron (2791.12 ng/g, dry weight) > little egret (1979.97 ng/g, dry weight) > cattle egret (660.11 ng/g, dry weight). DDT and its metabolites accounted for 90% of the total organochlorines, except that it was only 73% for cattle egret. The differences of the residue among the bird species were statistically significant and could be attributed to their variations in prey and habitat. Although the DDE burdens in Tai Lake were much lower than 8 microg/g (wet weight) which are thought to have significant adverse effects on black-crowned night herons, they would be expected to increase the risk of adverse effects on survival of chicks of herons and egrets, particularly black-crowned night heron, based on the critical value of 1 microg/g (wet weight) DDE. The burdens of HCHs in this study were higher and the cyclodienes were lower than those found elsewhere.

Animals↗

PubMedDate not supplied

On Leucocytozoon parasites of Ardeidae and description of one species.

In peripheral blood of Nycticorax nycticorax and Egretta garzetta (Aves, Ardeidae), gametocytes of the genus Leucocytozoon (Protozoa, Sporozoa) were found. We describe this parasite and compare it with the past records of Leucocytozoon in Ardeidae. While only life cycle studies will give a definitive answer to these taxonomic problems, we put forward an hypothesis about taxonomy of Leucocytozoon in Ardeidae.

Animals↗

PubMedDate not supplied

Tissue damage after acute intoxication by polychlorinated biphenyls in cockroaches.

It is common knowledge that polychlorinated biphenyls (PCBs) represent a serious threat to the health of both vertebrates and invertebrates. As far as the former are concerned, especially as regards human beings, a broad literature describes the direct and indirect effects induced by the PCBs on their systems and organs. Among invertebrates, the information available is mostly related to arthropods and is, however, very scarce. The aim of this work was to evaluate the effects of polychlorinated biphenyls (PCBs) on tissues and organs of individuals belonging to a species of Blattaria (Blattella germanica) treated with various doses of this toxic material. The pathologies found became more serious as the dosage increased and were present throughout the entire digestive system, in the fat body and in the male gonads: in these areas cell and tissue breakdown and severely damaged spermiogenesis were observed. In particular, the testes, Malpighian tubules and fat body accumulated an amorphous basophilic PAS-positive substance. Furthermore, the NOS-dependent NADPH diaphorase activity pattern in the retina and optic lobes was more evident in the treated than in the control insects.

Animals↗

PubMedDate not supplied

Significance of hepatitis C virus genotypes and viral load in patients with "essential" mixed cryoglobulinemia.

Several studies have established a strong association between hepatitis C virus (HCV) infection and essential mixed cryoglobulinemia (EMC). However, the mechanisms by which HCV infection may result in cryoglobulinemia in some patients but not in others remain unknown. In this paper we shall summarize some of the work done in our laboratories on certain aspects of HCV in patients with EMC.

Cryoglobulinemia↗