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Biomedical subjects

M Fedele

Publications and source records attributed to M Fedele.

46 records · Page 3Linked to original sources
PubMedDate not supplied

[Combined vaginal and laparoscopic surgical treatment of genito-urinary prolapse].

BACKGROUND: A new combined technique for vaginal prolapse and cystocele using minimal access surgery is presented and evaluated. METHODS: Thirty-five patients (mean age 57.1) with genitourinary prolapse (II-IV degree Baden-Walker) without urinary incontinence underwent surgery between January 98 and December 99 with 4-24 months of follow-up (mean 14.6 months). The surgical stages include total vaginal hysterectomy with bilateral adnexectomy, wide opening of the vagina without excessive removal of the vaginal mucosa; the bladder is loosened and the polypropylene mesh (PPM) is lightly fixed to the bladder and stitched to the anterior and posterior vaginal wall. The PPM is introduced into the abdomen and laparoscopically fixed to the sacral promontory with titanium spirals having checked vaginally the right tension of the mesh. Accurately laparoscopic peritonization of the PPM ends the surgical procedure. RESULTS: The operation time was 90'-140' (mean 112') followed by 3-7 days of hospitalization (mean 4.3). Vaginal prolapse and cystocele were corrected in all cases. No surgical complications, de novo urinary incontinence, prolapse recurrence or inconvenience to sexual activity have been observed. There was one erosion of the vaginal wall by the PPM 45 days after the operation. CONCLUSIONS: Initial studies suggest that laparoscopic sacrocolpopexy and cystocele repair with PPM is an effective treatment for genitourinary prolapse. If subsequent studies will confirm these findings, the development of minimal access techniques for genitourinary prolapse will represent a significant surgical advance.

Aged↗
PubMedDate not supplied

[Hormonal regulation of uterine contraction].

A personal method has been used to study spontaneous kinetic activity of the uterus in 50 women during puerperium following miscarriage between the VIIIth and XIIth weeks. Modifications induced were evaluated in several sessions (510 recordings) and at various periods of time, following administration of: 50 mg of 17B oestradiol, 200 mg natural progesterone, 500 mg of natural progesterone, 250 mg of 17 hydroxyprogesterone caproate and 500 mg of 17 hydroxyprogesterone caproate. In the case of some of the patients, hysterotonometry was evaluated following intravenous oxytocin loading. The results pointed to an activation of the uterine pacemaker after oestrogenic loading, and a clear-cut progestinic block of contractile activity.

Abortion, Spontaneous↗
PubMedDate not supplied

[Effect of estradiol on carbohydrate metabolism in the uterine musculature].

The Effect of 7.5 micrograms i.v. 17-beta-oestradiol on the sugar metabolism of the uterine musculature was studied in 180-200 g Wistar rats. The myometrial metabolic reaction consisted of increased glucose phosphorylation, enhanced utilisation of creatine phosphate, and increased production of adenosine triphosphate and creatine phosphate initially, followed by their consumption. The gradual fall in the lactate: pyruvate ratio showed that this stimulation of glycolysis was not occurring in the absence of oxygen.

Adenosine Diphosphate↗