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Biomedical subjects

M Feder

Publications and source records attributed to M Feder.

32 records · Page 2Linked to original sources
PubMed1985

Preleukemia and leukemia with 12p- and 19q+ chromosome alterations following Alkeran therapy.

Among 20 patients with acute nonlymphocytic leukemia or dysmyelopoietic preleukemia secondary to Alkeran therapy for another tumor, four had a del(12)(p11-p12) and four had a translocation to 19q13 among multiple karyotypic alterations in their neoplastic hematopoetic clones. It is suggested that these two cytogenetic abnormalities may occur nonrandomly in such hemic disorders and may play a limited role in their pathogenesis.

Chromosome Deletion↗
PubMed1985

A 2p;11q chromosome translocation in dysmyelopoietic preleukemia.

Three patients with dysmyelopoietic preleukemia had a marrow clone with translocation t(2;11)(p21;q23) as the only chromosome change. In one patient, the cytogenetically altered cells disappeared following treatment with 13-cis-retinoic acid. Although these patients did not constitute a homogeneous clinical subgroup, the 2p;11q translocation should probably be added to the short list of nonrandom karyotypic alterations involving 11q23 that have been described in various hematopoietic disorders.

Aged↗
PubMed1984

Human neuroblastomas and abnormalities of chromosomes 1 and 17.

Structural rearrangements of chromosome 1p have been reported previously as a frequent finding in human neuroblastomas. In a review of karyotypes from 35 neuroblastomas (including 29 published cases and 6 unpublished tumors and cell lines), it was found that, in addition to the abnormalities of chromosome 1p (found in approximately 70% of cases), abnormalities involving only 2 other chromosome segments occurred with significant frequency (in 20% or more of cases) in this cancer. These abnormalities involved trisomies for the long arms of chromosomes 1 and 17. In addition, two novel cytogenetic aberrations, homogeneously staining regions and double minutes, were identified in two-thirds of the cases. It is postulated that the gene change(s) produced by the abnormalities of chromosome 1p in neuroblastoma play a primary role in the development of this cancer. The gene changes produced by the abnormalities of chromosomes 1q and 17q and by the homogeneously staining regions and double minutes are presumed to contribute to tumor progression.

Cell Line↗
PubMedDate not supplied

[Intervention methods in the practice of gerontology; the Geneva experience].

The definition of intervention: modifying the course of events - can be both a challenge or an invitation to criticism. The real question in geriatrics is what should be done - not what can be done. In our article we have tried to describe our geriatric action in Geneva. Multidisciplinary services, an attempt at integrated psychiatry, the geriatric hospital and day hospital are described. The new programs include patient discussion groups, instructions for medical students, for doctors, staff, volunteers, and a nurses dossier. Most important is the intervention of the aged subject himself - the help the young aged can give to the old aged with proper training and direction.

Aged↗