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Biomedical subjects

M Fernex

Publications and source records attributed to M Fernex.

At least 37 records · Page 2Linked to original sources
PubMed1984

Interferon as an adjuvant for hepatitis B vaccination in non- and low-responder populations.

To determine the effect of interferon on the production of antibodies against hepatitis B virus, recombinant alpha-interferon was added only to the fifth vaccine injection in a non-responder group and to all three initial vaccine injections in a low-responder group. In the non-responder group, 27% of the hemodialysis patients, 7% of the renal transplant patients, and both medical staff members tested developed low serum concentrations of anti-HBs (less than 25 mU/ml). Whereas in the low-responder group 60% of the hemodialysis patients developed the same amount of antibodies as a placebo group of comparable patients (greater than or equal to 25 mU/ml), 78% of the renal transplant patients showed a 25% higher antibody concentration than a placebo group (half less than 25 mU/ml;half less than 50 mU/ml). According to these preliminary findings alpha-interferon may have an adjuvant effect on hepatitis B vaccination.

Adjuvants, Immunologic↗
PubMed1976

Metabolic studies with 5-fluorocytosine-6-14C in mouse, rat, rabbit, dog and man.

Metabolism of 5-fluorocytosine-6-14C (5-FC) was studied in mice, rats, rabbits and dogs after oral and subcutaneous, single and repeated administration. In the urines of all species, intact 5-FC accounted for more than 90% of the total radioactivity at any time of the various treatment schedules. The average proportion of the urinary metabolites was around 5% in dogs, 3% in rabbits, 2.5% in rats, and 2% in mice of the total radioactivity. At repeated dosage, there was an increase of metabolites in mice but a decrease in rats treated subcutaneously. Neither increase nor decrease was observed in rabbits (treated orally) and dogs. Two metabolites were identified, alpha-fluoro-beta-ureido-propionic acid (FUPA) and alpha-fluoro-beta-alanine, the latter occurring mainly after oral treatment. These compounds represent probably that part of 5-FC which was deaminated to 5-fluorouracil (5-FU) or directly to 5-fluorodihydrouracil. FUPA was the only metabolite found in the urines collected from 4 out of 5 human volunteers during the first 12 h after single oral administration of 3.5 g of the radiolabelled drug. Its maximum proportion was 1.1% of the total radioactivity. No metabolites were detected in the urine neither of the 5th volunteer nor in those of 3 mycosis patients who were given the radioactive dose after they had received regular chemotherapy with unlabelled 5-FC (150 mg/kg/day) for at least 2 weeks. The sensitivity threshold of the method was 0.1-0.4% of the total radioactivity. One of the patients had developed thrombocytopenia which was probably due to 5-FC chemotherapy. The symptoms of 5-FC intolerance were in most of the examined species similar to those observed with 5-FU [9]. However, no quantitative correlation between proportion of metabolites and 5-FC toxicity is apparent except that man is the species in which both metabolism and toxicity are the lowest. It has not been proved yet that 5-FC intolerance occurring in a small percentage of patients receiving 5-FC chemotherapy (mainly leukopenia, thrombocytopenia) results in fact from conversion to 5-FU.

Administration, Oral↗