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M Ferraro

Publications and source records attributed to M Ferraro.

At least 73 records · Page 4Linked to original sources
PubMed1984

Analysis of the DNA replication pattern of a translocation (tX/X, qter----p221::p223----qter) chromosome in leukocyte and fibroblast cultures.

The results of a detailed analysis of DNA replication in a late replicating tX/X chromosome (qter----p221::p223----qter) are reported. The chronology of DNA replication has been analyzed by comparing (a) the replication patterns of each of the two moieties of the translocation chromosome in different cells and (b) the two moieties with each other in the same cell. The study has been done on leukocyte and fibroblast cultures after BUdR incorporation. A comparison with the late replication pattern of the normal X chromosome has also been done.

Cells, Cultured↗
PubMed1984

Characterization of discrete and continuous modes of visual pattern discrimination.

Discrete and continuous modes of visual pattern discrimination performance are analyzed using a model for the investigation of discrete internal pattern representations described in previous papers (Foster, 1980a, b). A simple quantitative criterion is derived to characterize the two kinds of visual discrimination performance. Values predicted by this criterion are then compared with values obtained from experimental data.

Cybernetics↗
PubMed1983

Activation of human ribosomal genes by 5-azacytidine.

Cultured human fibroblasts were exposed to 5-azacytidine which inhibits methylation of newly synthesized DNA. A significant increase in the mean number of Ag-stained active nucleolus organizers has been observed in treated cells. This suggests that DNA methylation is involved in modulation of human rRNA synthesis.

Azacitidine↗
PubMed1983

The effect of five drugs in coma doses on neurotransmitter amino acids in the brains of guinea pigs.

The study has been carried out in order to investigate the effects of some drugs in coma doses on the concentration in brain of some amino acids involved in brain function. Six groups of 25 guinea pigs each were utilized. In each of the five groups a subcutaneous dose of diazepam, flunitrazepam, phenobarbital, phenytoin or alfaxalone, was injected and one group was utilized as control. Some neurotransmitter amino acids (glutamate, aspartate, glycine and taurine) and precursors of neurotransmitters (phenylalanine and tyrosine) were determined in brain preparations. The results are discussed.

Amino Acids↗
PubMed1983

Screening for cytogenetic polymorphisms in a random sample of liveborn infants from Italian population.

The frequency of major and minor chromosome variants is studied in a random sample of newborns in Central Italy. Special attention is paid to the objective criteria used to evaluate minor variants. In our sample, the frequency of acrocentric chromosome variants is found to be unusually high compared with previous studies. Also, the distribution of C-band sizes differs from that reported for other populations, while the frequency of major chromosome variants is found to be the same.

Chromosome Banding↗
PubMed1982

Silver staining of the nucleolus organizer regions (NOR) requires clusters of sulfhydryl groups.

Silver stainability of nucleolus organizer regions (NORs) appears to be correlated with the presence of grouped sulfhydryl (SH) side chains of proteins. In fact, heavy metals with high affinity for SH groups, such as Hg and Cu, do prevent the silver staining reaction. Ferricyanide, which is known to oxidize SH to disulfides, also prevents any further reaction with silver. On the other hand, alkali and reducing agents (mercaptoethanol, cyanide) do not affect silver stainability of the NORs. These results show that the silver staining reaction is not related to disulfide or persulfide groups and that alkali-soluble, acidic nuclear proteins per se do not play a major role in this process.

Cell Nucleolus↗
PubMed1981

Clonal inheritance of rRNA gene activity: cytological evidence in human cells.

Clone-specific silver staining patterns of the nucleolus organizers (NOs) were observed in clones deriving from a human diploid fibroblast culture. Each specific staining pattern corresponds to one of the nine patterns observed in the general population. Since silver stainability of the NOs is related to rRNA gene function, these data demonstrate the clonal inheritance of rRNA gene activity.

Cells, Cultured↗
PubMed1981

A model of visual perception.

In this paper we propose a model of visual perception in which a positive feedback mechanism can reproduce the pattern stimulus on a neurons screen. The pattern stimulus reproduction is based on informations coming from the spatial derivatives of visual pattern. This information together with the response of the feature extractors provides to the reproduction of the visual pattern as neuron screen electric activity. We simulate several input patterns and prove that the model reproduces the percept.

Computers↗
PubMed1981

Premenstrual syndrome and personality traits: a study on 110 pregnant patients.

Five specific personality traits (emotivity, acceptance of sexual role, parental aptness, anxiety and depression) have been analyzed for this study of the premenstrual syndrome (PMS), conducted on a group of 110 women in advanced (8th month) pregnancy. The comparison of the results from the personality tests and from the overall assessment of the PMS (82%) establishes definite correlations between the syndrome's intensity and the tendency toward a pathologic personality. A further correlation of each personality trait and of the PMS shows that the greater deviation from normalcy affects not only those women who suffer from a severe PMS, but also those who complain of no premenstrual symptoms at all. Such a finding (as shown in the results of a separate previous study by our group) allows to conclude that a psychological normalcy or balance finds its equivalent in an absence, but more often in a scarce presence of premenstrual complaints, while an absolute absence or a very marked intensity of these complaints should correspond to the more extreme degrees of personality disturbance.

Adult↗
PubMed1981

[Identification of drugs in toxic doses in biological fluids using infrared Spectrophotometry].

A method permitting rapid analysis of biological samples from patients suspected of being intoxicated is reported. The method is based on: a) extraction of the active principles of biological samples with chloroform; b) drying and preparation of a disc of KBr; c) spectrophotometric analysis; d) integration of data from laboratory analyses with the clinical data from the patient. A number of clinical cases are also reported in which adoption of the method permitted rapid diagnosis of the possible aetiology of the toxic pictures observed.

Body Fluids↗
PubMed1980

[A case of pseudocyst of the right adrenal gland. Clinical case report].

A case of pseudocyst of an asymptomatic right suprarenal gland found by chance is reported. Some aetiopathogenetic, anatomopathological and clinico-radiological aspects of the condition are discussed and, after reviewing the possible complications that may arise out of a suprarenal cyst, the value of surgery is stressed.

Adrenal Gland Diseases↗
PubMed1980

Cytological evidence for the location of male-determining and H-Y genes on the short arm of Y chromosome.

Chromosome analysis was performed in a case of mixed gonadal dysgenesis (MGD) with histological demonstration of both testicular structures and Müllerian derivatives. Mosaicism 45,X0/46, X plus a centric fragment was observed. C-, Q- and R-banding techniques show that the fragment has a terminal centromere and that it is derived from the short arm of the Y chromosome from the father. H-Y antigen was also shown to be present in cultured cells. These data demonstrate that both male-determining and H-Y genes are located on the short arm of the Y.

Aneuploidy↗
PubMed1980

Cytogenetic and clinical studies in gonadal dysgenesis with 46,X,Xt(qter leads to p221::p223 leads to qter) karyotype: review and phenotype/karyotype correlations.

Chromosome analysis by Q, R, and C banding was performed in a case diagnosed clinically as gonadal dysgenesis and the karyotype was shown to be 46,X,Xt(qter leads to p221::p223 leads to qter). Localisation of the breakpoints in the fused X chromosomes and replication studies have led to a hypothesis on the origin of the translocation. A comparison of clinical and cytogenetical findings in this and other published cases has also been made in an attempt to detect some phenotype/karyotype correlations.

Adult↗
PubMed1979

[Angioma of the parotid gland in children. Considerations on 3 cases].

Three cases of haemangioma of the parotid observed in infants are presented and their aetiopathogenetic and anatomopathological aspects are stressed. An examination of the pros and cons of conservative, surgical, radiation, and pharmacological management leads to the conclusion that surgery is the treatment of choice, provided a suitable technique is employed.

Child, Preschool↗
PubMed1978

Ag staining of the nucleolus organizer (NO) and its relationship to satellite association.

The frequency of involvement in satellite association and the frequency of selective staining of the secondary constrictions with silver solutions have been studied in five phenotypically normal individuals, all carriers of morphological variants of the nucleolus organizing region (NOR). The results show the preferential involvement of some morphological markers in satellite association, and also their preferential staining with Ag-I. It has also been shown that acrocentric chromosomes involved in satellite association are always stained by silver.

Cell Nucleolus↗