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M Finch

Publications and source records attributed to M Finch.

70 records · Page 4Linked to original sources
PubMed1983

An assessment of the contribution of clonidine metabolised from alinidine to the cardiovascular effects of alinidine.

Five healthy volunteers (mean age 20.6 years, mean weight 71 kg) received in random order on day 1 and day 8 a single dose of alinidine 40 mg, clonidine 0.1 mg or placebo and on days 2-7 alinidine 40 mg, clonidine 0.1 mg or placebo given three times a day with 1 week between treatment periods. Blood samples were taken for measurement of concentrations of alinidine and clonidine during alinidine administration and of clonidine during clonidine dosing. Heart rate and blood pressure were recorded in supine and standing positions and heart rate after 3 min exercise. Plasma concentrations of alinidine reached a maximum of 163.6 +/- 10.0 ng/ml 2 h after alinidine administration on day 1 and during chronic administration similar concentrations were achieved. Clonidine plasma concentrations reached 0.3 +/- 0.11 ng/ml 6 h after alinidine 40 mg on day 1, and during chronic administration of alinidine, increased to a steady state on day 5 with trough and 2 h values of 0.73 +/- 0.15 and 0.86 +/- 0.14 ng/ml respectively. After the first dose of clonidine on day 1, the maximum plasma concentration of clonidine was 0.32 +/- 0.1 ng/ml at 4 h, during chronic administration clonidine plasma concentration rose to 1.04 +/- 0.14 ng/ml 2 h after a dose on day 5. Alinidine produced a greater reduction in the exercise tachycardia than clonidine.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1982

Damaging effects of fourteen chemotherapeutic drugs on mouse testis cells.

The harmful effects of 14 chemotherapeutic drugs on spermatogenesis in the mouse have been evaluated by studies of testicular cell killing and morphological and genetic damage produced. Male mice were given drugs as single injections at various doses up to the toxic levels. Prednisone and 6-mercaptopurine produced little or no cytotoxicity. All other drugs tested killed differentiated spermatogonia. Of these, methotrexate, cyclohexylchlorethylnitrosourea, cis-platinum, and mechlorethamine did not show significant stem cell killing. Bischlorethylnitrosourea, chlorambucil, 5-fluorouracil, mitomycin C, antinomycin D, and procarbazine showed some stem cell killing. Triethylenethiophosphoramide (thio-TEPA) was the only drug in this group which killed large numbers of stem cells. Only 5-fluorouracil and cis-platinum killed spermatocytes, and only cis-platinum killed spermatids. Several drugs induced chromosome breaks in treated spermatocytes. Thio-TEPA was effective in inducing chromosome translocations in treated spermatocytes and probably also in spermatocytes which originated from surviving treated stem cells. It had been our hypothesis that the cytotoxic effects of these drugs on mouse testicular stem cells would correlate with the duration of azoospermia observed in patients. This was shown not to be the case. Thus, the cytotoxic effects of single injections of single chemotherapeutic agents on the mouse testis did not appear to be predictive of which drugs will cause long-term azoospermia in humans.

Animals↗
PubMed1980

Effect of razoxane (ICRF 159) on daunomycin (NSC 82151) metabolism and DNA complexation.

Daunomycinol and deoxyaglycone were the two major metabolites obtained from daunomycin in vitro metabolism by rat and mouse liver preparations. Pretreatment with razoxane (ICRF 159) in these animals did not appear to alter these major metabolic enzymes. In an in vitro system, it was found that daunomycin reacted with DNA instantly and reached steady states within two minutes as evidenced by the diminishing, shifting or disappearance of certain and visible regions. Preincubation of razoxane with DNA did not alter the latter's capacity to interact with daunomycin. We suggest that the mode of razoxane-protected daunomycin-induced toxicities in mice is not mediated through an alteration in daunomycin metabolism or its complexation with DNA.

Animals↗
PubMed1977

Nuclear fluorescence of liver cells for IgG in viral hepatitis B: significance and relation to hepatitis B-core and anti-hepatitis B-core formation.

The occurrence of anti-HBcAg antibodies in the blood as determined by indirect immunofluorescence and its relation to the occurrence of HBsAg in the cytoplasm and of HBcAg and IgG in the nuclei of hepatocytes were studied in the following groups of patients (total of 123 biopsies): I. 64 HBAg-negative patients with various liver diseases; II. 51 HBAg-positive patients without therapeutical immunosuppression (6 acute hepatitis, 10 nonspecific reactive and 10 chronic persistent hepatitis, 19 chronic aggressive hepatitis, 6 "Hippie"-hepatitis); III. 8 kidney transplant recipients. It could be shown that nuclear IgG is found only if both parameters can be demonstrated at the same time: HBcAg in liver cell nuclei and anti-HBcAg antibodies in the serum in titers higher than 1:64. Accordingly, all types of hepatitis with excess formation of nuclear HBcAg (early phase of acute hepatitis, chronic aggressive hepatitis and chronic non-aggressive forms with generalized core formation, i.e. carrier state or chronic persistent hepatitis of the HBc type) may show nuclear fluorescence for IgG. All forms of hepatitis B without detectable core formation (acute hepatitis in the elimination phase, chronic non-aggressive hepatitis with isolated HBsAg expression, i.e. carrier state or chronic persistent hepatitis of the HBs type, posthepatitic phase) do not present nuclear IgG despite eventual anti-HBcAg formation. Finally, lack of anti-HBcAg or very low titers associated with lack of IgG in hepatocytic nuclei do not exclude generalized core formation in liver cell nuclei in chronic persistent hepatitis of effectively immunosuppressed patients. Although the demonstration of nuclear IgG has several diagnostic and prognostic consequences in common with the demonstration of HBcAg, a specific search for the core antigen in the tissue is needed for the correct appraisal of the HBcAg- and HBsAg tissue expression pattern and the associated disease.

Antigen-Antibody Complex↗
PubMed1974

Orthopedic exhibits.

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Exhibitions as Topic↗
PubMedDate not supplied

Electromyographic and kinematic analysis of cutting maneuvers. Implications for anterior cruciate ligament injury.

The objective of this study was to qualitatively characterize quadriceps and hamstring muscle activation as well as to determine knee flexion angle during the eccentric motion of sidestep cutting, cross-cutting, stopping, and landing. Fifteen healthy collegiate and recreational athletes performed the four movements while knee angle and electromyographic activity (surface electrodes) of the vastus lateralis, vastus medialis obliquus, rectus femoris, biceps femoris, and medial hamstring (semimembranosus/semitendinosus) muscles were recorded. The results indicated that there is high-level quadriceps muscle activation beginning just before foot strike and peaking in mid-eccentric motion. In these maneuvers, the level of quadriceps muscle activation exceeded that seen in a maximum isometric contraction. Hamstring muscle activation was submaximal at and after foot strike. The maximum quadriceps muscle activation for all maneuvers was 161% maximum voluntary contraction, while minimum hamstring muscle activity was 14%. Foot strike occurred at an average of 22 degrees of knee flexion for all maneuvers. This low level of hamstring muscle activity and low angle of knee flexion at foot strike and during eccentric contraction, coupled with forces generated by the quadriceps muscles at the knee, could produce significant anterior displacement of the tibia, which may play a role in anterior cruciate ligament injury.

Adult↗
PubMedDate not supplied

Hospital ownership of post-acute care: does it increase access to post-acute care services?

This study examines the relationship of hospital characteristics and access to post-acute care (PAC) using a comprehensive database that combines hospital characteristics with clinical and demographic information of patients. The data was drawn from 52 hospitals in three urban areas--Minneapolis/St. Paul, Houston, and Pittsburgh--and 2,572 patients within five diagnosis-related groups (DRGs). The analysis found hospital ownership of post-acute care significantly associated with use of PAC for patients discharged after hospitalization for stroke and chronic obstructive pulmonary disease (COPD). We found few significant hospital characteristics influencing use of PAC, but, as expected, for selected DRGs, patients were more likely to receive PAC if they were discharged from a hospital that either owned post-acute care or served a high proportion of Medicare patients. In general, patient characteristics were more consistent predictors of post-acute care use across the DRGs studied.

Activities of Daily Living↗