Biomedical subjects
Publications and source records attributed to M FitzPatrick.
Primary tumors of the optic nerve are uncommon. The most common are optic nerve gliomas (ONGs), which account for 66% of all primary optic nerve tumors. Seventy-five percent of gliomas are diagnosed in the first decade of life, and 90% are diagnosed in the first two decades. This article discusses the anatomy and imaging of the optic pathway and the clinical manifestations of ONGs.
This article reviews the complex anatomic relationships between structures in the sellar and parasellar regions. Normal anatomy and the normal imaging spectrum are reviewed, with emphasis on the diversity of pathology that originates from this region. Both CT and MR imaging may be used to evaluate the sellar and parasellar regions. This article discusses how modern imaging techniques enable characterization of the many lesions that alter the structure and function of normal sellar and parasellar anatomy.
We report the first case of pathologic findings from brain biopsy in a patient with Sneddon's syndrome. The observations suggest that Sneddon's syndrome is not a vasculitis but is more comparable to the autoimmune vasculopathies such as the antiphospholipid antibody syndrome. Vascular thrombosis and emboli from cardiac sources are the likely causes of stroke in most cases. The success of warfarin in the treatment of antiphospholipid syndromes and the failure of immunosuppression and aspirin in the treatment of Sneddon's syndrome argue that warfarin anticoagulation may be the most appropriate intervention currently available.
Intraosseous infusion, a mode of peripheral access largely abandoned in the 1940s and 1950s, is becoming increasingly popular in the setting of pediatric crisis. While complications are rare when the procedure is properly performed, the risk of osteomyelitis increases with prolonged infusions. We present a case of bilateral osteomyelitis secondary to intraosseous infusion.
We examined the effect of dexamethasone (DXM) pretreatment on microvascular transport of macromolecules in ischemia-reperfusion injury. The rat cremaster muscle was splayed, placed in a Lucite intravital chamber, and suffused with bicarbonate buffer. The clearance of fluorescein isothiocyanate-dextran 150 (FITC-Dx 150) was measured as an index of microvascular transport. After determination of baseline data, the muscle was made ischemic for 2 hr by clamping its vascular pedicle, and subsequently reperfused for 2 hr. Ischemia-reperfusion produced a marked increase in clearance of FITC-Dx 150. After an initial peak of 13 times baseline value clearance fell to approximately 4 times baseline level 30 min into the reperfusion period. Clearance increased slowly throughout the remainder of the experiment, reaching 6 times baseline after 2 hr of reperfusion. The treated animals received DXM 3 hr prior to and immediately preceding the pedicle clamping. DXM reduced macromolecular clearance significantly after the first 30 min of reperfusion, and prevented the increase in clearance over time. After an initial peak, clearance values fell to near twice baseline in DXM-treated animals, and remained at this level for the 2 hr of reperfusion. Our data demonstrate that DXM attenuates the alternations in microvascular macromolecular transport produced by ischemia-reperfusion injury.
Explore the source record for details and available documents.