Misoprostol-associated fever in cirrhotic patient.
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Biomedical subjects
Publications and source records attributed to M Fortier-Beaulieu.
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We describe a 68-year-old woman with multicentric reticulohistiocytosis. The patient's symptoms responded well to methotrexate 7.5 and then 10 mg/week orally. After 34 months of treatment, her disease was still in remission.
Clinicopathological findings and outcomes in ten pediatric cases of lichen sclerosus and atrophicus of the foreskin are reported. This well-defined entity usually presents as acquired sclerous phimosis. Diagnosis rests on histologic studies of biopsy specimens. Pathologic features change during the course of disease and are useful for selecting the most appropriate therapy. Local corticosteroid therapy may be helpful in early disease. However, circumcision is usually required for advanced disease, failure of medical therapy or prevention of squamous cell carcinoma. Pathophysiology is discussed. The incidence of this condition seems to be underestimated. Possible connections with diabetes mellitus and other conditions are reviewed.
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Six personal cases of digestive tract involvement in dystrophic recessive epidermolysis bullosa are reported, and the relevant literature is reviewed. The study deals with the clinical aspects of these cases (buccal and dental lesions, digestive symptoms, effects on nutritional status; table I), as well as with their biochemical (table II), radiological and endoscopic aspects (table III, fig. 1 and 2). All patients presented with bucco-dental lesions, including two cases of congenital abnormalities: one with malposition and dysgenesis of the teeth, the other with dysplasia of the enamel in a patient whose dystrophic skin disease was proven by electron microscopic study. The oesophagus was involved in six cases, with tight concentric stenosis (2 cases), retrocricoidal stenosis (1 case) and oesophagitis (2 cases). No gastro-duodenal or intestinal lesions were detected. A case of constipation was related to anal involvement. The patients' nutritional status was investigated clinically and biochemically. A search for intestinal malabsorption by means of specific tests was conducted in 2 patients and proved negative. A study of the literature provided data on the nature and specificity of dental lesions. The morphological features, complications and physiopathology of oesophageal stenoses are described The existence of gastrointestinal lesions is discussed. Nutritional repercussions are presented and their causes are discussed. Attention is paid to the medical and surgical treatments of these lesions.
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In four children, aged respectively 2, 6, 8 and 11 years, an abnormality of the aortic arches was discovered fortuitously during bronchoscopy. The latter was carried out in an attempt to assess bronchial lesions in children suffering from chronic or recurrent bronchopneumonia. The authors stress the importance of careful examination of the mediastinum in such cases, the diagnosis of the causal vascular abnormality (double aortic arch in all four cases) being possible by simple radiological examinations with no element of aggression.
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