PubMed Health⌕ Search

Biomedical subjects

M Foxworthy

Publications and source records attributed to M Foxworthy.

3 recordsLinked to original sources
PubMed1996

Antibacterial activity of peptides homologous to a loop region in human lactoferrin.

Human lactoferrin contains a 46 residue sequence named lactoferricin H thought to be responsible for its antimicrobial properties. Synthetic peptides HLT1, corresponding to the loop region of human lactoferricin (FQWQR-NMRKVRGPPVS) and HLT2, corresponding to its charged portion (FQWQRNMRKVR), exerted significant antibacterial effects against E. coli serotype O111 strains NCTC 8007 and ML35. The corresponding sequences in native human lactoferrin were shown to adopt a charged helix and hydrophobic tail within the N-lobe remote from the iron binding site. Sequence similarities between lactoferricin and dermaseptin and magainins suggest that lactoferricin may act as an amphipathic alpha helix.

Amino Acid Sequence↗
PubMed1995

Dynamization timing and its effect on bone healing when using the Orthofix Dynamic Axial Fixator.

We report the effect of dynamization timing on healing rates when treating tibial fractures with the Dynamic Axial Factor (Orthofix, registered trademark). Sixty-nine patients with 71 fresh tibial fractures were grouped retrospectively for age, Gustilo and Anderson wound grading, site of tibial fracture and presence of an intact fibula or stable fibular fracture. Pairs were then generated chronologically to compare healing rates in those patients dynamized before 4 weeks with those dynamized after this time. This resulted in 22 pairs of patients; the other fractures could not be paired. Their healing times were compared using a paired t-test and were found to be significantly quicker in the group dynamized within the first 4 weeks (P < 0.05) and we therefore recommend that this should be routine practice.

Adolescent↗