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M Foz Sala

Publications and source records attributed to M Foz Sala.

16 recordsLinked to original sources
PubMed2003

[Application of a method for the early detection of diabetic retinopathy in Primary Health Care].

PATIENTS AND METHODS: An ophthalmic examination was performed in 1,495 diabetic patients by means of a photographic method with a non-mydriatic retinal (Ffo-CNM) camera (with inclusion of 81.5% of the total diabetic population in our area attended in three primary care centers in Terrasa, Barcelona. RESULTS: The prevalence of diabetic retinopathy known prior to the study was 15% (n = 218). With the application of the Ffo-CNM method the prevalence increased up to 28% (p = 0.0001). The diagnoses obtained were: normal fundoscopic appearance (bilateral), 61% (n = 908), DR without maculopathy, 22% (n = 334); DR with maculopathy, 5% (n = 75); severe DR or preproliferative DR, 0.1% (n = 1), and proliferative DR, 0.7% (n = 10). The fundus was not visible in 11% (n = 167) of patients, mainly because of darkness refractory miosis (48%) and media opacity (43%). Thirty-nine percent of examined patients were referred to the referral Ophthalmology department either because DR or non-visible eye fundus. CONCLUSIONS: The use of Ffo-CNM enhances the ophthalmoscopic examination in the diabetic population given the simplicity of the technique and its accessibility with the corresponding increase in the number of diagnoses of DR. Likewise, it improves the care quality to the diabetic patient and also the reationalization of patient referral to the ophthalmologic centers.

Cross-Sectional Studies↗
PubMed2002

[Socio-demographic and clinical characteristics of a patient population with diabetes mellitus].

OBJECTIVES: To describe sociodemographic and clinical characteristics of a diabetic population. To relate sociodemographic and clinical evolutionaries variables. DESIGN: Descriptive transversal study. SETTING: Three urban Primary Health Centers (PHC). Participants. Diabetic patients attended in these PHC.Measurements. VARIABLES: sociodemographic and clinical through an individualized survey and a medical record review. RESULTS: 1495 patients were studied from whom 96% were diabetic type 2. Age: 66 years old (SD 12). Sex: 56% were women. Education level: 62 didn't have finished their primary studies. Family: 71% live together with a partner. Years of evolution: Diabetes (DM) < 10 years: 47% in type 1; 64% in type 2. RISK FACTORS: DM 1: smokers 40%; hypertension (HTA) 7%; DM 2: smokers 12%; HTA 51%; obesity 26%; hypercholesterolemia 28%; hypertriglyceridemia 17%. Chronic complications: DM 1: retinopathy (DR) 26%; nephropathy (Nf) 3.5%; ischemic heart disease (IHD) 3.5%; periferic arteriopathy (PA) 7%; Cerebrovascular accident (CVA) 2%; peripheric neuropathy (PN) 5%. DM 2: DR 14%; Nf 13%; IHD 12%; PA 9%; CVA 5%; PN 4%; autonomic neuropathy 3%. Metabolic control DM 2: 67% HbA1c 7.5. Best metabolic control in DM with less years of evolution (p = 0.001). Treatment DM 2: 32% diet, 51% oral treatment, 13% insulin, 4% mixed. No relation with cultural level and family situation with metabolic control. In chronic complications only DR were more prevalent in patients with less cultural level (p = 0.037). CONCLUSIONS: Less cultural level doesn't influence neither metabolic control nor appearance chronic complications, except DR. The knowledge of diabetic population attended has allowed to detect the need of reinforce the intervention for decrease smoking and increase chronic complications detection.

Adolescent↗
PubMed1998

[Defects of adrenal steroidogenesis in patients with hirsutism].

BACKGROUND: To determine the frequency and the type of adrenal steroidogenic abnormalities in hirsute women. SUBJECTS AND METHODS: ACTH test was performed during follicular phase in 127 hirsute and 40 normal (control) women. Before ACTH injection we measured in serum by RIA: 17-OH-pregnenolone (17-OH-P5), 17-OH-progesterone (17-OH-P4), androstenedione (AN), cortisol (CT), 11-deoxycortisol (DCT), dehydroepiandrosterone (DHEA) and its sulphate (DHEAS), total (TT) and free (FT) testosterone, oestradiol (E2), progesterone (PR), androstenediol glucuronide (AG), LH, FSH and prolactin. After 60 min of ACTH injection 17-OH-P5, 17-OH-P4, AN, DHEA, CT and DCT were measured. Net increment of stimulated steroids and the ratios 17-OH-P5/17-OH-P4, DHEA/AN, 17-OH-P4/CT, 17-OH-P5/CT and DCT/CT were calculated. Pelvic ultrasonographic exploration was done when irregular menses were reported. RESULTS: Up to 31% of the patients presented enzymatic defects in adrenal steroidogenesis. Diagnostic criteria for enzyme defects were established. Late-onset 21-hydroxylase deficiency was diagnosed in 6 (4.5%) patients, HLA typing of these patients demonstrated that 4 out of 6 had B14-DR1. Sixteen women (12.6%) displayed a 17-OH-P4 response and the net increment 2 SD above the normal mean concentration, which are diagnostic criteria for late-onset 21-hydroxylase deficiency carriers. We diagnosed a 3 beta-hydroxysteroid dehydrogenase defect when 17-OH-P5 and DHEA responses, their net increment and the 17-OH-P5/17-OH-P4 and 17-OH-P5/CT ratios were 2 SD above the normal mean after ACTH: 14 women were diagnosed. 11 beta-hydroxylase deficiency diagnosis was made when DCT response, its net increment and the DCT/CT ratio after ACTH were 2 SD above the normal mean: 7 women were detected. Associated biosynthetic defects were described. CONCLUSIONS: One third of our patients with hirsutism presented anomalous response to ACTH, consistent with enzymatic abnormalities in adrenal steroidogenesis.

17-alpha-Hydroxypregnenolone↗
PubMed1992

[The use of molecular epidemiologic markers in the study of an epidemic outbreak of legionnaires' disease of nosocomial origin].

BACKGROUND: Epidemiological investigations of Legionella infections are based, since recently, on molecular techniques that are more sensitive and specific than phenotypic traits. We were interested in these methods for subtyping isolates of L. pneumophila serogroup 1 and confirm the epidemic spread of an outbreak of legionnaires' disease at the Universitary Hospital Germans Trias i Pujol (HUGTiP) in Badalona. METHODS: Environmental samples taken from domestic water, heating and cooling water systems and oxygen humidifiers were examined. Clinical and environmental isolates of L. pneumophila serogroup 1 were compared by analysis of genomic DNA by restriction endonucleases. RESULTS: We could found L. pneumophila serogroup 1 and 9 in domestic hot water and heating systems and L. micdadei in cooling water system. Cleavage of genomic DNA showed that all restriction fragment patterns coming from clinical and environmental isolates of L. pneumophila serogroup 1 were identical and different from isolates belonging to the same species and serogroup but coming from community area. CONCLUSIONS: Molecular analysis of clinical and environmental isolates of L. pneumophila serogroup 1 has allowed to identify a reservoir related to a nosocomial outbreak of legionnaires' disease at the HUGTiP, and a clonal population of L. pneumophila serogroup 1 in environmental samples genotypically identical to the clinical ones.

Cross Infection↗
PubMed1991

[Anthropometric changes and nitrogen balance in patients with morbid obesity treated with very low calorie diet].

BACKGROUND: Morbid obesity is associated with increased morbidity and mortality. In these patients, weight reduction reduces associated morbidity and increases life expectancy. The aim of the present study was to evaluate the anthropometric changes in a group of patients treated with a very low caloric diet and to assess nitrogen balance and clinical and biological tolerance. METHODS: Overall 65 patients were prospectively evaluated (12 males and 53 females with a mean age of 45 +/- 7 years. Mean initial weight was 110 +/- 21 kg, with a Quetelet index of 43 +/- 7 kg/m2. They were treated as inpatients during 42 days exclusively with a very low caloric diet. They also followed a physical exercise program during one hour daily. RESULTS: The weight reduction was 15 +/- 4 kg (p less than 0.0001) with a reduction in fat mass of 9 +/- 2 kg (p less than 0.0001) and a reduction in fat-free mass of 6 +/- 3 kg (p less than 0.0001). The Quetelet index was reduced in 5 +/- 1 points (p less than 0.0001). There was also a reduction in the muscle adipose index from 1 +/- 0.2 to 0.7 +/- 0.2. The nitrogen balance remained negative throughout the 42 study days, although with a clear trend towards equilibrium. There were significant reductions in blood glucose, proteinemia, total cholesterol and subfractions. Triglycerides did not show significant changes. Clinical tolerance was excellent in all cases except 4 who withdraw from treatment because of nausea and vomiting. CONCLUSIONS: In this study, very low caloric diet achieved satisfactory weight reduction, basically at the expense of adipose tissue, reflected in a reduction of the muscle adipose index. Nitrogen balance remained negative throughout the treatment but with a trend towards normalization. Tolerance was excellent in 61 of the 65 cases (94%).

Adolescent↗
PubMed1989

[Study and significance of cryoimmunoglobulins in chronic liver diseases].

The presence, composition and significance of cryoglobulins was studied in a group of 80 patients suffering from different chronic liver diseases. 43 patients (53.75%) had detectable levels of cryoglobulins and there was a significant correlation (p less than 0.02) between the presence of these and the group of chronic active hepatitis. The immunochemical analysis of the cryoglobulins showed a clear predominance of type III (mixed polyclonal). There was a statistically significant correlation (p less than 0.001) between the appearance of cryoglobulins in chronic liver disease (in general) and extrahepatic clinical manifestations. When the subgroups were analyzed, this correlation was significant in the group of patients with chronic active hepatitis (p less than 0.002) and in those with liver disease of unknown origin (p less than 0.001). The type of cryoglobulins most frequently found in the group of patients with extrahepatic manifestations was also type III (mixed polyclonal).

Adolescent↗