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Biomedical subjects

M Frajman

Publications and source records attributed to M Frajman.

9 recordsLinked to original sources
PubMed1987

Cellular immunity and IgE levels in atopic patients.

Twenty young adult atopic patients and their matched controls were studied. Spontaneously generated and Con-A-induced suppressor T cell functions as well as Natural Killer (NK) activity against K-562 target cells, measured in a short-time 3H-thymidine uptake, were evaluated. Suppressor T cell activity in the patients was more than 2 SD lower than that found in the controls and there was, contrary to expectation, a direct correlation between suppressor function and serum IgE levels. Atopic patients showed a statistically significant lower NK activity than normal controls when related to a low IL-2 production. Both facts inversely correlated with the concentration of IgE in serum. We concluded that atopic patients' vulnerability to viral infections may be due to defective NK activity. Suppressor T cell function is abnormal in these patients. Both defects could be due to a faulty immunoregulatory helper function.

Adolescent↗
PubMed1986

Effect of tinidazole on the cellular immune response.

A single 500 mg dose of tinidazole was given to fourteen healthy volunteers. Cellular immune functions were studied, before and 2 and 24 h after drug ingestion. Blast transformation of lymphocytes to Con-A was significantly lower (P less than 0.01) in samples obtained 2 h after ingestion. No significant changes were found in the other immunological parameters studied. We conclude that these findings could be caused by reversible blockage of lectin binding receptors on the lymphocyte surface.

Adult↗
PubMed1985

Rosette formation between T and autologous B lymphocytes. I. Characterization of a T cell subpopulation.

The ability of some T cells to form rosettes with autologous B lymphocytes (TrB cells) appears to be a marker of a subpopulation of T cells, a majority of which have high avidity receptors for sheep red blood cells. TrB cells have a higher proportion of suppressor cell surface markers (OKT-8+ and receptor for the Fc fraction of IgG), as well as higher suppressor activity than other T cell populations. TrB cells also help in B lymphocyte transformation under the stimulation of a T-dependent B mitogen. The TrB cells seem to express the Fc gamma receptor after ecotatic association with B cells, since T gamma cells previously isolated from total T cells form rosettes with B cells in the same proportion in which total T cells do. Studies on TrB cells subpopulation may explain some of the defects in functional cell-cell interactions.

B-Lymphocytes↗
PubMed1983

Effect of pregnancy on functions of circulating T cells from patients with systemic lupus erythematosus: correction of T-cell suppression and autologous mixed-lymphocyte responses.

Pregnant systemic lupus erythematosus (SLE) patients with inactive disease were found to have normal spontaneously generated suppressor-cell function and slightly higher concanavalin A-induced suppressor function as compared to matched normal pregnant and nonpregnant females. In six SLE patients studied sequentially throughout pregnancy and postpartum, suppressor functions were found to fall sharply within the first week after delivery. One of these patients had been studied before she became pregnant and found to have a decreased suppressor function. Nonpregnant SLE patients had both suppressor functions diminished despite their disease being similarly inactive. This group was also the only one to have decreased responses in autologous mixed-lymphocyte cultures. Both pregnant and nonpregnant SLE patients had decreased absolute numbers of total lymphocytes, T cells, and their subpopulations, but the proportions of these cells were similar in all four groups. Despite this apparent normalcy of immune regulation, pregnant SLE patients had higher levels of Clq-binding immune complexes than did nonpregnant ones. Functional T-cell abnormalities found in SLE patients tend to be corrected by pregnancy. This may explain in part the disease remissions that occur in them during the second half of pregnancy.

Concanavalin A↗
PubMedDate not supplied

Immunologic studies in patients with Takayasu's arteritis. II. Effects of serum on lymphocyte functions in vitro.

Natural lymphocytotoxic antibodies, circulating immune complexes and their effect on in vitro blast transformation of normal cells were studied in 24 patients with Takayasu's arteritis. Sera with Takayasu's arteritis lacked lymphocytotoxic antibodies, had an inhibitory effect on the formation of EA and EAC rosettes and interfered with normal lymphocyte function in vitro. The absence of lymphocytotoxic antibodies, together with the other epidemiological and histocompatibility studies, would support the notion that Takayasu's arteritis and temporal arteritis are two distinct entities.

Adult↗