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M Frisch

Publications and source records attributed to M Frisch.

98 records · Page 6Linked to original sources
PubMed1993

Trends in incidence of anal cancer in Denmark.

OBJECTIVE: To study long term trends in incidence of anal cancer in a well monitored, unselected population. DESIGN: Descriptive epidemiological study based on data from the Danish Cancer Registry. SETTING: Denmark, 1943-87. MAIN OUTCOME MEASURES: Time related changes in anal cancer incidence according to sex, age, birth cohort, urban or rural residence, and marital status. RESULTS: The incidence of anal cancer remained fairly constant in the period 1943-57 and was similar for men and women, but it increased 1.5-fold among men and nearly tripled among women thereafter. Among men the incidence increased from 0.25 per 100,000 population (world standardised) in 1958-62 to 0.38 in 1983-7 (p = 0.01) and among women from 0.28 to 0.74 (p < 0.01). The greatest increase was among residents of the capital (Copenhagen). During 1943-87 age specific trends increased in young and middle aged men and in all age groups among women. Men with anal cancer were significantly more likely throughout the study period to be unmarried than were patients with cancer of the colon (adjusted odds ratio 2.7; 95% confidence interval 2.0 to 3.6) and stomach (2.1; 1.5 to 2.8), but no association with marital status was found among women. CONCLUSIONS: The distribution and incidence of anal cancer have changed appreciably since around 1960, especially among women, which indicates important aetiological changes. Changes in sexual behaviour may have facilitated the spread of a transmittable agent of aetiological importance. It has recently been suggested that cigarette smoking promotes anal cancer, and this finds indirect support in the synchronism between changes in anal cancer incidence and heavy smoking behaviour. Factors associated with homosexuality are likely to explain some of the cases among men.

Adult↗
PubMed1993

Survival of Danish cancer patients 1943-1987. Eye, brain and nervous system, thyroid, bone and connective tissue.

The cancers covered in this chapter are those of the eye, brain and nervous system, thyroid, bone and connective tissue. Generally, detailed interpretations of data on cancers of the bone and connective tissue are inadvisable owing to small numbers of patients and major changes in diagnosis and registration over time. A slight but steady increase in survival was observed among patients diagnosed in 1943-87 with cancer of the eye. Relative five year survival increased from 60 to 68% in men and from 61 to 74% in women during the 45-year period. The predominant type of eye cancer seen in children, retinoblastoma, had a very favourable prognosis, with a relative five year survival rate of more than 80% since around 1960. Since that time, overall survival for patients with cancers of the brain and nervous system also increased. Relative five year survival improved from 25 to 36% in men and from 34 to 48% in women during 1960-85. Our data do not indicate to which extent therapeutic and diagnostic advances underlie the improvement in survival. Overall survival of patients with thyroid cancer also increased during 1943-87. Relative five-year survival improved from 26 to 58% in men and from 28 to 68% in women. Some of the improvement reflects earlier diagnosis of localized tumours, particularly in young women. A substantial improvement in survival was observed among children and adolescents (< 20 years) diagnosed in 1943-87 with primary bone cancers. Over the study period, the relative five-year survival in that age category and increased from 25 to 48% in males and from 16 to 52% in females. Use of adjuvant chemotherapy in cases of Ewing's sarcoma and osteosarcoma contributed importantly to the improvement in prognosis. Overall survival of patients with soft-tissue cancer associated with no specific organ increased until approximately 1970, after which time no further improvement was observed. The decreased survival seen in women during the last decade of the study is puzzling; the increase in mean age at diagnosis would only partially explain it.

Adolescent↗
PubMedDate not supplied

Syphilis and the risk of penis cancer.

BACKGROUND AND OBJECTIVES: Until recently, syphilis was considered a major cause of penis cancer. The possible role of syphilis was discarded without much debate with the detection of certain of human papillomaviruses centrally involved in the etiology of penis cancer. GOALS: To reevaluate the association between syphilis and penis cancer by using truly population-based cancer and syphilis data and to generate a more sound basis for judging the possible role of syphilis in the etiology of penis cancer. STUDY DESIGN: Patients with epidermoid cancer of the penis, totalling 1,523, were diagnosed and reported to the Danish Cancer Registry from 1943 to 1990. Through linkage with the Danish Syphilis Registry, the impact of prior syphilis infection was evaluated in a case-control design using patients with colon cancer or stomach cancer as controls. RESULTS: Depending on the criteria used to assess prior syphilis status, 3% to 5% of patients with penis cancer had had syphilis before the cancer diagnosis. The corresponding proportions were 2% to 4% among patients with colon cancer and 2% to 5% among patients with stomach cancer. Logistic regression showed that patients with penis cancer did not have a syphilis history significantly more often than control cancer patients. CONCLUSION: Syphilis should be removed from the list of possible causes of penis cancer.

Adult↗