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Biomedical subjects

M Fujiwara

Publications and source records attributed to M Fujiwara.

At least 919 records · Page 51Linked to original sources
PubMed1976

Effect of repeated bloodletting on the incidence of 2,7-FAA-induced rat leukemia.

The oral administration of N,N'-2,7-fuorenylenebisacetamide (2,7-FAA) induced leukemia, especially mature granulocytic leukemia, in rats. 2,7-FAA was administered to the rats of the Wistar strain and a small amount of bloodletting was repeated for a long period. The incidence of leukemia and mature granulocytic leukemia became elevated by bloodletting. The induction of mature granulocytic leukemia might be increased by the promotion of granulopoiesis which had been suppressed by 2,7-FAA.

2-Acetylaminofluorene↗
PubMed1976

Influence of blood collection on incidence of 2,7-FAA induced rat leukemia.

The oral administration of N, N'-2,7-fluorenylenebisacetamide induced leukemia, especially mature granulocytic leukemia, in rats. The peripheral blood was examined on various schedules, once or twice a week for a long term. The blood volume lost by a blood collection was little, but it was not negligible in small animals such as rats when the loss was repeated. We investigated the relationship between the volume of blood loss and the incidence of leukemia. The incidence of leukemia rose as the volume of blood loss increased. There was a positive correlation between them. The induction of mature granulocytic leukemia was thought to be increased by the promotion of the granulopoiesis which had been suppressed by 2,7-FAA. It was concluded that the blood loss by repeated blood collection for examination raised the incidence of 2,7-FAA induced leukemia.

2-Acetylaminofluorene↗
PubMed1976

Adrenergic neuron blocking action of dehydrocorydaline isolated from Corydalis bulbosa.

Dehydrocorydaline, an active principle of Corydalis bulbosa alkaloids, in concentrations of 10(-5) M to 5 x 10(-5)M inhibited relaxation and the concomitant release of (3H)-noradrenaline caused by 10(-4)M nicotine and electrical perivascular nerve stimulation in the taenia caecum of guinea pig. The same inhibitory effects were observed on contraction and release of (3H) noradrenaline in the sympathetic nerve-pulmonary artery preparation of rabbit. On the other hand, neither relaxation nor contraction caused by exogenously applied noradrenaline was affected. These results suggest that the inhibitory action of dehydrocorydaline on the relaxation or contraction, produced by nicotine and electrical nerve stimulation, is due to blockade of noradrenaline release from the adrenergic nerve terminals in both the taenia caecum and pulmonary artery. Participation of the adrenergic neuron blocking action of dehydrocorydaline in preventing experimental ulceration is discussed.

Alkaloids↗
PubMed1976

Nonparticipation of adrenergic mechanism in potassium-induced relaxation of taenia from guinea pig caecum.

In the isolated taenia caeci of guinea pigs excess potassium (10-30 mM) induced a phasic relaxation followed by a contraction. This phasic relaxation was unaffected by treatment with hexamethonium, phentolamine, propranolol and bretylium. However, relaxation induced by perivascular nerve stimulation was inhibited by all these agents but not by hexamethonium. Tetrodotoxin inhibited both forms of relaxation. Potassium-induced relaxation was not accompanied by [3H]noradrenaline release. Perivascular nerve stimulation caused release of [3H]noradrenaline and this was blocked by bretylium. Treatment with ouabain or replacement of NaCl by LiCl, but not treatment by cold storage, inhibited the potassium-induced relaxation. These results suggest that the potassium-induced relaxation of taenia caeci was due to electrogenic sodium pumping and was independent of the adrenergic innervation of the tissue.

Animals↗
PubMed1976

[Behavioral pharmacology of a new antidepressant, lopramine].

The behavioral effects of lopramine [N-methyl-N-(4-chlorobenzoyl-methyl)-3-(10, 11-dihydro-5H-dibenz (b,f) azepin-5-yl) propylamine hydrochloride] were investigated in mice and rats and compared with those of amitriptyline and imipramine. Lopramine inhibited reserpine hypothermia and haloperidol catalepsy in mice and tetrabenazine ptosis in rats. In addition the drug potentiated the effects of methamphetamine, and DOPA- or apomorphine-induced stereotypy in mice, whereas it suppressed muricide of the rat induced by either olfactory bulbectomy or delta9-tetrahydrocannabinol, similar to the responses seen with imipramine and amitriptyline. On the other hand,lopramine increased spontaneous motor activity and markedly potentiated methamphetamine hyperactivity. In contrast to imipramine and amitriptyline, lopramine failed to counteract both the lethal effect of physostigmine and oxotremorine tremor in mice, indicating that the drug had no central anticholinergic effect. Lopramine, even at such a large dose as 5,000 mg/kg p.o., caused neitherimpairment of coordinated motor activity nor muscle relaxation. It is concluded that lopramine is a new type of tricyclic antidepressant with extremely low toxicity and without central anticholinergic action.

Amitriptyline↗
PubMed1976

Activation and suppression of T cells in termination of immunological tolerance.

Immunological tolerance was induced in adult C3H mice by five injections of ultra-centrifuged, soluble HSA at weekly intervals. The tolerant state was readily terminated by the challenge immunization with slightly sulphanilated HSA administered as Freund's complete adjuvant emulsion. In this case, it was shown that T cells specific for HSA were activated which could serve as helpers for the production of anti-hapten antibodies. The tolerance termination and activation of T cells specific for HSA was not observed in the profound tolerant state, induced by nine injections of ultra-centrifuged, soluble HSA at weekly intervals, where suppressor T cells were detected. Implications of these results were discussed in reference to the development of autoimmunity.

Animals↗
PubMed1976

Hip abnormalities in cerebral palsy: radiological study.

A total of 237 hips of children with cerebral palsy were examined annually for three years. The severely involved spastic children and those who had never stood were more susceptible to hip abnormality. Apparent coxa valga (whose phenotype consists more of anteversion and less of true coxa valga) is closely related to the hip abnormality.

Age Factors↗