PubMed Health⌕ Search

Biomedical subjects

M Fukuchi

Publications and source records attributed to M Fukuchi.

At least 91 records · Page 5Linked to original sources
PubMed1984

Somatostatin-like immunoreactivity in rat thyroid. Age-associated S-cell hyperplasia.

Somatostatin-like immunoreactive cells of the rat thyroid gland at various ages were investigated immunohistochemically. The number of cells per lobe in 5 micron sections increased with age. Immunopositive cells were evident as small clusters in the older age group (8 to 24 months old) but not clustered in the younger age group (3 to 5 months old). This type of proliferation was termed S-cell hyperplasia in a manner similar to C-cell hyperplasia observed in the aged rat thyroid.

Aging↗
PubMed1984

Malignant pheochromocytoma with ACTH production.

An autopsy case of a 54-year-old woman with malignant pheochromocytoma and ectopic ACTH production was reported. Noradrenaline was increased in 24 hour urine and in the blood sample from the left adrenal vein. Hormone assay studies of the tumor tissue and plasma revealed abnormally high levels of ACTH. Formaldehyde fume induced fluorescence method demonstrated biogenic amine in the tumor cytoplasm. Electron microscopic examinations also disclosed numerous neurosecretory granules in the tumor cytoplasm. These findings confirmed that this pleomorphic carcinoma of the left adrenal gland was one of the APUDoma originating from the adrenal medulla, so-called pheochromocytoma.

Adrenal Gland Neoplasms↗
PubMed1984

Primary C cell hyperplasia of the thyroid in Fischer 344 rats. An immunohistochemical study.

C cell proliferation of the thyroid, which was designated as primary C cell hyperplasia (PCCH), was demonstrated in aged Fischer 344 rats in high incidence using the immunohistochemical method for calcitonin. It developed from mild to severe PCCH and resulted in nodular PCCH and tumor formation. The combined incidence of PCCH and nodular PCCH was increased with age and appeared in 60.7% of 7-15 month old group and 92.7% of 16-24 month old group possibly as a preneoplastic C cell lesion. It is almost an equivalent C cell lesion reported in the human thyroid with familial C cell carcinoma and therefore this Fischer 344 rat can provide a useful animal model to study familial C cell tumor of the thyroid.

Animals↗