PubMed Health⌕ Search

Biomedical subjects

M Fukuyama

Publications and source records attributed to M Fukuyama.

At least 73 records · Page 4Linked to original sources
PubMed1986

Acute effects of captopril on the baroreflex of normotensive and spontaneously hypertensive rats.

When captopril was injected intravenously in urethane anesthetized rats, a hypotensive effect accompanied by bradycardia was obtained, while an intravenous (i.v.) injection of prostaglandin I2 (PGI2), which induced hypotension of the same magnitude as the hypotensive effect obtained with captopril, caused a marked tachycardia. Simultaneously, sympathetic nerve activity recorded from abdominal sympathetic nerves was unchanged following injection of captopril, while it was significantly increased during hypotension induced by PGI2. The bradycardia, but not the hypotensive effects induced by captopril was abolished by i.v. pretreatment with atropine. Intracisternal injection of a small dose of captopril inhibited reflex tachycardia during hypotension induced by PGI2 and prolonged the hypotensive effect, while intravenous administration of this dose did not inhibit the reflex tachycardia induced by PGI2. In spontaneously hypertensive rats (SHR), the hypotensive effect of captopril was increased partly, however, the accompanying bradycardia was significantly reduced. These findings suggest that captopril inhibits the baroreflex and centrally activates the cardiac vagal nerve. Moreover in SHR, the effect of captopril on cardiac vagal activity was disturbed.

Animals↗
PubMed1986

[A case of successfully resected abdominal aortic aneurysm complicated by arteriocolic fistula].

A 80 year-old man was admitted to our hospital with profuse rectal bleeding. Two weeks prior to admission he was diagnosed as having abdominal aortic aneurysm when he had first herald of rectal bleeding. Aortoenteric fistula was strongly suspected and patient underwent emergency operation. Bilateral axillofemoral bypass were first constructed in order to avoid contamination in hte peritoneal cavity. On laparotomy aneurysm was contaminated because of arteriocolic fistula and resection of aortoiliac aneurysm and Hartmann procedure were performed. In the postoperative course, formation of an intra-abdominal abscess, obstruction of the left axillo-femoral bypass graft and enlargement of a residual aneurysm occurred. The prolonged antibiotic therapy was successful and additional repair operations were performed. Abdominal aortic aneurysm complicated with arteriocolic fistula is a rare but lethal disease. To our knowledge, only 13 cases have been reported in the literature including our case. Eleven patients were operated but only 3 survived. Construction of an extra-anatomic bypass, avoidance of an anastomosis in unprepared bowel and aggressive use of antibiotics are recommended because fecal contamination to the aneurysm is inevitable in most cases.

Aged↗
PubMed1985

Peripheral origin of plasma dopamine.

To clarify the peripheral origin of plasma dopamine (DA), we studied the changes in plasma levels of free and conjugated catecholamines after nephrectomy, adrenalectomy, chemical sympathectomy and renal denervation. Nephrectomy markedly increased conjugated DA levels, indicating that plasma DA is rapidly excreted through the kidney and originates outside the kidney. Adrenalectomy reduced plasma total epinephrine (E) to undetectable limits, whereas total norepinephrine (NE) and DA levels remained unchanged. In addition, the subsequent immobilization stress significantly increased both total NE and DA, but not E. Chemical sympathectomy with 6-hydroxydopamine decreased both NE and DA by 66% and 72%, respectively. E level, however, was not affected by sympathectomy. Although the following immobilization stress significantly increased all catecholamines levels, the magnitude of increase in concentrations of NE and DA were much less than that of E. These results suggest that plasma DA is mainly derived from the peripheral sympathetic nerve terminals. However, the renal nerve, one of the sympathetic nerves, did not serve as a source of plasma DA because renal denervation had no effect on plasma DA levels in spite of the marked depletion of free DA in the kidney.

Adrenalectomy↗
PubMed1982

[Clinical evaluation of tissue concentrations of cefotiam applied in the field of thoracic surgery].

Seven patients who were performed thoracotomy for the disease of the chest, were administered cefotiam dihydrochloride 2.0 g for about an hour by intravenous drip infusion during their operation. Antibiotic levels of serum and intrathoracic tissues (a piece of lung parenchyma, parietal pleura, pulmonary hilar lymph node, chest wall muscle, pulmonary cyst and nerve) were determined, and an evaluation of bactericidal effect was discussed. In this study, we found that antibiotic level of poor blood supplied lung, so called the destroyed lung was remarkably high. This means that a high concentration of cefotiam dihydrochloride to intrathoracic tissue is effective against postoperative infection.

Adult↗