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M Furlanut

Publications and source records attributed to M Furlanut.

51 records · Page 3Linked to original sources
PubMedDate not supplied

Steady-state serum concentrations of imipramine, its main metabolites and clinical response in primary enuresis.

Thirty-seven children (6-13 years old), receiving a flexible dosage of imipramine (IMI) for nocturnal enuresis, were evaluated. After a mean time of 8.5 +/- 7.0 weeks of therapy, 40.5% no longer wet the bed; 32.4% had a mean benefit of 80%; 27.01% had a negligible response. The best relationship observed was between clinical effect and drug serum concentrations rather than with drug daily dose, the most satisfactory being that with IMI seric values (P = 0.019). Responders (effect higher than 50%) had higher IMI serum concentrations (P less than 0.05) than poor responders. At 3 and 6 months after stopping the drug, over 90% of the responders maintained the maximum response reached during treatment. The side-effects observed were irritability, reduction of appetite, headache, a mild increase of blood pressure.

Adolescent↗
PubMedDate not supplied

The pharmacokinetics of tricyclic antidepressant drugs in the elderly.

Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding TCAs) is not sufficiently developed. The present paper briefly reviews the available data on amitriptyline, nortriptyline, protriptyline, imipramine, desipramine and clomipramine kinetics in the elderly.

Aged↗
PubMedDate not supplied

[Clinical evaluation of clotiazepam in the ambulatory treatment of anxiety states].

To assess the therapeutic efficacy and tolerability of Clotiazepam in the treatment of anxiety, the drug was administered to 20 subjects suffering from anxiety (12 cases) or from nervous depression (8 cases), all of whom were without psychopharmacological drugs for at least one month prior to the trial. Treatment with Clotiazepam improved the anxiety and brought about a statistically significant reduction in both groups of patients regards the total score in the Hamilton Scale and in the two sub-scale scores (somatic and psychological symptoms). Tolerability to the drug was very satisfactory.

Adult↗
PubMedDate not supplied

[Changes in plasma nonesterified fatty acids and blood glucose in the newborn infant in therapy with aminophylline].

We investigated the effect of intravenous infusions of aminophylline on plasma glucose and nonesterified fatty acid (NEFA) levels in 14 newborns with apnea (mean birthweight: 2.514 +/- 866 g; mean gestational age: 34.8 +/- 3.94 weeks). Theophylline apparent volume of distribution was 0.55 liters per Kilogram and the half-life was major than 12 hours. It was found that theophylline caused pronounced and prolonged lipid mobilization, as measured by the plasma NEFA. The ability of theophylline to induce a rapid rise in blood glucose was confirmed. Elevation in plasma NEFA might be an important factor in facilitating the competition with bilirubin for binding sites of albumin and the development of arrythmias in newborns with acute myocardial injury.

Aminophylline↗