[Experimental studies on fate of autogenous vein graft transplanted to peripheral artery, special reference to fibrinolytic activity of intima (author's transl)].
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Biomedical subjects
Publications and source records attributed to M Furuyama.
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Two patients having the abdominal aneurysm with aortoduodenal fistula were treated surgically, but graft infection occurred. One patient died about 6 months after and the other about one year after the operation due to massive hemorrhage from the postoperative aortointestinal fistula. The difficulties in the treatment of the aortoduodenal fistula were discussed.
A male child with chronic granulomatous disease is described in whom glutathione peroxidase deficiency of leukocytes was identified. Stability and activity of G-6-PD and activity of NADPH oxidase were normal. The leukocytes of the parents showed intermediate activities of glutathione peroxidase, suggesting the possibility of autosomal recessive inheritance.
A wide variety of influenza A viruses, comprising human, equine, porcine, and avian strains, grew productively in an established line of canine kidney cells (MDCK) under an overlay medium containing trypsin, and formed well-defined plaques regardless of their prior passage history. Plaquing efficiency was comparable to the efficiency of infection in fertile eggs via allantoic route. MDCK cells have also been successfully employed for the primary isolation of influenza A virus from throat washings of patients. Parallel titration of several clinical specimens showed that the inoculation into MDCK cells followed by incubation in the presence of trypsin was an isolation procedure as sensitive as the amniotic inoculation into fertile eggs.
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Direct selective observation of the intravascular lumen through a catheter cardioangioscope provides accurate diagnostic information that facilitates the detection and treatment of vascular diseases. The Sumida-cardioangioscope is approximately 0.75 to 2.4 mm in diameter and consists of at least 3,000-6,000 delicate glass fibers, each measuring 4.8-5.5 micron and fused into a long flexible 75 to 130 cm tube. The cardioangioscope has the following components: (1) a scope connected to a camera; (2) a lightguide, consisting of 80-500 fibers, measuring 30-50 micron in diameter, and a 75-watt xenon lamp; (3) a transport channel for saline or drug solution; (4) an inflatable cuff; and (5) a handle to manipulate the catheter tip. The abdominal aorta in living dogs and the coronary arteries, aortic valves, abdominal-iliac, femoral and popliteal arteries, abdomino-iliac bifurcation, and venous system were clearly observed and recorded on videotape, 16-mm movie film and 35-mm photographic film. Angioplasty by balloon and laser ablation are possible applications.
A revascularization procedure for extensive arterial occlusive lesions of the lower extremity, namely "A-V shunt procedure" was devised. The occluded popliteal artery is recanalized by open endarterectomy in association with E-PTFE bypass for occlusion of the superficial femoral artery, and the patency of reconstructed arterial segments is ensured by an arterio-venous shunt created at the distal end of the recanalized tibio-peroneal trunk. The branches of the genicular arterial network are also reopened by a technique of thrombectomy. Numerous collaterals develop through the reopened genicular network increasing blood flow to the ischemic distal areas. From 1967 to 1980, 63 extremities in 57 patients, which had extensive arterial occlusions of lower extremities with impending ulcer and/or severe rest pain in their feet or toes, underwent this procedure. Remarkable improvement of ischemic symptoms resulted in 76.2% of extremities at the time of the hospital discharge and 57.1% in follow-up.