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Biomedical subjects

M G Aliev

Publications and source records attributed to M G Aliev.

At least 19 recordsLinked to original sources
PubMed1990

[The stimulation of prolactin secretion by the simultaneous inhibition of the dopaminergic and activation of the serotoninergic systems in the hypothalamus].

Lactotropic adenohypophyseal function and lactation intensity were studied under simultaneous blockade of dopamine receptors and stimulation of serotonin metabolism in the rat hypothalamus. Blockade of hypothalamic dopamine receptors by tricedil decreased the dopamine level, increased the serotonin content and intensified its metabolism thus increasing the prolactin secretion. Under these conditions, tryptophan application potentiated the above changes in hypothalamic catecholamine and indolamine metabolism, increased the prolactin secretion. The latter is associated with the brain serotoninergic system reactivity to suckling impulses: an important factor in the lactation reflex. Tryptophan maintains a high level of hypothalamic serotonin metabolism, maintaining an increase in the prolactin secretion level and secretory activity of the mammary glands.

Animals↗
PubMed1986

[Secretion of somatotropic hormone in patients with pancreatitis].

The concentration of somatotropic hormone (STH) was measured by radioimmunoassay in 108 patients with acute and chronic pancreatitis and in 15 healthy persons. In addition, to study the reserve capacity of the somatotropic function of the pituitary, insulin hypoglycemia was employed. It was established that during exacerbation, the pancreatitis patients manifested an increase in the hormone content. In the patients suffering from acute pancreatitis, the STH level returned to normal following treatment. In chronic pancreatitis, the hormone concentration remained elevated after treatment. No correlation was discovered between alterations in the STH level and the activity of pancreatic enzymes. The data obtained point to a definite role of STH in the pathogenesis of chronic pancreatitis.

Acute Disease↗
PubMed1983

[Effect of sulpiride on the hypothalamic monoaminergic regulation of prolactin formation and milk secretion].

Administration of sulpiride to lactating female rats reduced the content of dophamine and norepinephrine and increased the content of serotonin (5HT) in the hypothalamus. The inhibition of DA in the hypothalamus resulted in an increase of prolactin and growth hormone contents in the pituitary gland. Thus the level of prolactin is increased in the blood plasma of lactating rats. The increase of prolactin content in the pituitary gland and in blood caused an obvious stimulation of lactation.

Animals↗
PubMedDate not supplied

[Neuroendocrine system function in early hypogalactia].

A study was made of the state of the hypophyseogonadal, hypophyseoadrenocortical, hypophyseothyroid systems and the level of regulatory neuromediators in puerperae with a different intensity of lactation. Early hypogalactia was shown to be a neuroendocrine pathology affecting the central links of regulation of lactation as well as function of the peripheral endocrine glands.

Adult↗
PubMedDate not supplied

[Use of tryptophan and thyroidin for complex correction of hormonal disorders in experimental hypogalactia in rats].

The interlinked functioning of the hypothalamo-hypophyseo-breast and hypothalamo-hypophyseo-thyroid systems in experimental hypogalactia (electric stimulation) as well as a possibility of effective correction of neuroendocrine disorders of lactation were studied using tryptophan in combination with microdoses of thyroidin. The hypothalamic and blood concentrations of monoamines (MA) were determined by fluorometry (spectrofluorometers SFM-22, Contron, Switzerland), the blood levels of hormones were determined by a radioimmunoassay. The effect of chronic stress on the monoaminergic hypothalamic system was shown to be based on an increase in the catecholaminergic tone and suppression of serotoninergic tone. It resulted in the suppression of the synthesis and secretion of prolactin, STH, in an elevated blood level of TSH and a considerable reduction of the level of thyroid hormones. The result was weakened secretory function of the breast. Tryptophan and thyroidin administration to rats, subjected to stress, returned to normal function. The investigation brought to light the idea of pathogenesis of hypogalactia, resulting in a new approach to therapy of this pathological condition.

Animals↗