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Biomedical subjects

M G Cleary

Publications and source records attributed to M G Cleary.

4 recordsLinked to original sources

Post-pneumonectomy syndrome. Surgical correction using Silastic implants.

A post-right pneumonectomy syndrome is described which manifests symptoms of exertional dyspnea and inspiratory stridor on rapid inspiration. These symptoms were associated with marked rightward and posterior deviation of the trachea, over-distention of the left lung with its herniation into the right side of the chest and kinking of the left lower lobe bronchus. At the time of surgery, the tracheal deviation, lung herniation and the kink in the left lower lobe bronchus were immediately corrected by releasing the adhesions between the malpositioned structures and the right chest wall. To maintain the corrected positions, Silastic implants totalling a volume of 990 ml were placed into the space created in the right chest. Following surgery, exertional dyspnea was present with only extraordinary activity, and inspiratory stridor was eliminated. The patient remains asymptomatic three years following surgical correction, and is able to carry on a normal and productive life. We conclude that a syndrome associated with marked exertional dyspnea and inspiratory stridor might develop in situations of marked tracheal shift and overdistention of the remaining lung following right pneumonectomy.

Adult↗

Drug resistant tuberculosis in a large southern California hospital.

Rates of in vitro resistance to antituberculous drugs were examined for all patients hospitalized with active tuberculosis between January 1969 and December 1972, and between March 1975 and September 1976. During the former period, in 31.5 per cent of patients, tuberculosis was resistant to one or more drugs, and in 12.3 per cent of patients was resistant to 2 or more drugs. During the latter period, 35.5 per cent of patients had tuberculosis that was resistant to one or more drugs, and 19.6 per cent had tuberculosis resistant to 2 or more drugs. Resistance to isoniazid and ethambutol increased significantly, whereas resistance to para-aminosalicytic acid decreased. Age, national origin, and length of residence in the United States were not good predictors for the presence of in vitro resistance.

Aminosalicylic Acid↗

Effect of carotid body resection on ventilatory and acid-base control during exercise.

To investigate the role of the carotid bodies in exercise hyperpnea and acid-base control, normal and carotid body-resected subjects (CBR) were studied during constant-load and incremental exercise. There was no significant difference in the first-breath ventilatory responses to exercise between the groups; some subjects in each reproducibly exhibited abrupt responses. The subsequent change in Ve toward steady state was slower in the CBR group. The steady-state ventilatory responses were the same in both groups at work rates below the anaerobic threshold (AT). However, above the AT, the hyperpnea was less marked in the CBR group. Ve and acid-base measurements revealed that the CBR group failed to hyperventilate in response to the metabolic acidosis of either constant-load or incremental exercise. We conclude that the carotid bodies 1) are not responsible for the initial exercise hyperpnea, 2) do affect the time course of Ve to its steady state, and 3) are responsible for the respiratory compensation for the metabolic acidosis of exercise.

Acid-Base Equilibrium↗