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Biomedical subjects

M G Gonchar'

Publications and source records attributed to M G Gonchar'.

At least 19 recordsLinked to original sources
PubMed1990

[Morpho-functional changes in the muscles of the limbs and their microcirculatory bed in acute ischemia].

On 26 mature dogs in a chronic experiment the character of compensatory-adaptive changes in muscles and their blood capillaries have been studied in dynamics of an acute ischemia of the extremity and at some stages of recirculation. After strangulation for two hours, thanks to joining in the compensatory-adaptive mechanisms, certain morphofunctional changes in the extremity tissues are revealed. As the duration of hypoxia increases (6-9 h), the destructive changes in the tissues become more severe. They are inherent in an acute hypoxia and accompanied with disaggregation and hydratation of cell membranes of endotheliocytes, with formation of vesicles and spherules, with increasing microclasmatosis, formation of myelin-like bodies, with destructive changes of organelles, with destruction of sarcoplasmic reticulum, with focal discoid necrosis, myocytolysis and sequestration of autolysis altered groups of muscle fibers. The data obtained serves as a base for elaboration of a pathogenically adequate surgical treatment of severe forms of an acute ischemia of extremities.

Acute Disease↗
PubMed1989

[Morphologic changes in limb muscles under conditions of acute experimental ischemia and recirculation].

Acute ischemia was induced in the limbs of 48 dogs by wounding femoral vessels followed by hemostasis through ligation of the vessels or application of a tourniquet for 2, 4, 6 and 9 hours with subsequent blood flow restoration in the great vessels. Morphological changes were examined in the muscular tissues using light optic and ultrastructural techniques. The results showed that the vascular ligation caused reactive reversible nonspecific changes in the limb tissues, the magnitude of the changes was found to be associated with hypoxia duration. Tourniquet application is thought to induce a more severe injury and its 4-6-hour exposure leads to derangement of the compensatory and adaptative mechanisms responsible for homeostasis. The acute ischemia-induced structural changes found in the limb tissues may serve as a basis for morphological substantiation of the clinical classification developed by V. S. Savelyev and be useful for efficient treatment of post-ischemic disturbances.

Animals↗
PubMed1989

[Experimental substantiation of the use of regional detoxication therapy in acute ischemia of the limbs].

In the experiment on dogs, the authors modelled acute ischemia of the extremities and studied the activity of lactate dehydrogenase in the blood serum. In circulatory ischemia for 2 and 4 h, the metabolism in muscular tissue normalized by day 30 after restoration of blood flow. Circulatory hypoxia for 7 and 9 h led to failure of the compensatory-adaptive mechanisms of homeostasis of the muscular tissue and required performance of regional detoxication therapy before restoration of circulation in the extremity.

Acute Disease↗
PubMed1981

[Crohn disease].

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Adult↗