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Biomedical subjects

M G Kawooya

Publications and source records attributed to M G Kawooya.

9 recordsLinked to original sources

Sonography and risk factors for lower limb deep venous thrombosis at Mulago Hospital, Uganda.

BACKGROUND: Lower limb deep venous thrombosis (DVT), and its sequelae (lower limb chronic venous insufficiency and pulmonary embolism) are now well acknowledged as major haematological problems in the world, for which appropriate and accurate means of diagnosis is necessary. Developments in ultrasound have made it the imaging modality of choice in the diagnosis of lower limb DVT. OBJECTIVES: To determine the sonographic pattern, and identify the risk factors of lower limb DVT. DESIGN: Cross sectional, descriptive study carried out between April 2002 and March 2003. SETTING: Mulago Hospital, Uganda. SUBJECTS: Eighty six consecutive patients (92 limbs), with clinically suspected DVT, were studied by duplex sonography after a thorough risk factor evaluation. RESULTS: Out of a total of 86 patients clinically suspected to have lower limb DVT, 38 (44.2%) were found to have DVT after sonography. The gender incidence was similar. The left limb was affected in 60% of cases and the right in 40%. Bilateral DVT was noted in two patients. Most of the patients had acute and extensive DVT. CONCLUSION: Duplex ultrasonography is a very useful modality for assessing lower limb DVT, even in a low resource country like Uganda. It demonstrates the wealth of information obtained from sonography.

Adolescent↗

Comparison between sonographic and plain radiography in the diagnosis of small bowel obstruction at Mulago Hospital, Uganda.

OBJECTIVE: To evaluate the role of sonography compared to plain radiography in the diagnosis of patients with suspected small bowel obstruction as well as to determine their specificity, sensitivity and accuracy in the Ugandan setting. DESIGN: Prospective comparative study. SETTING: Mulago Hospital, Uganda's main referal Hospital and Makerere University Medical School. SUBJECTS: Seventy patients with suspected small bowel obstruction (SBO) were evaluated at Mulago Hospital between December 1998 and January 2000, 42 patients were males and 28 females. Patients were aged three days to two years and had a clinical suspicion of SBO. RESULTS: Of the 70 patients, 55 were confirmed to have had SBO. Four had ileus and 11 had no SBO. Sixty four per cent were managed surgically while 36% were managed conservatively. Sonography made a diagnosis of SBO in 92.7% and detected strangulation in 71% of patients. Plain radiography made a diagnosis in 85.5% of patients and did not detect strangulation. Specificity was 100% for both, sensitivity 93%, PPV 100%, NPV 73% for sonography. Sensitivity was 85%, PPV 100%, NPV 58% for plain radiography. MAIN OUTCOME MEASURES: The accuracy of sonography was 93% as compared to 87% for plain radiography. The level of obstruction was correctly predicted in 81% by sonography and 64% with plain radiography. CONCLUSION: It was concluded that sonography is as accurate, specific and sensitive as plain radiography in the diagnosis of SBO as well as determining the level of obstruction in a Ugandan setting. Sonography was found to be more accurate at determining the cause of obstruction and detecting strangulation. It is recommended that sonography should be the initial imaging modality for patients presenting with suspected SBO and plain radiography should only be used as a complimentary investigation.

Adolescent↗

Serial chest radiographs in the management of children with a clinical suspicion of pulmonary tuberculosis.

The aim of the study was to define the role of serial chest radiographs (SCR) in the management of children with a clinical suspicion of pulmonary tuberculosis (PTB) and to determine the interval at which they should be taken. Eighty children with a clinical suspicion of PTB were studied and followed-up for a duration of 18 months. SCR during the time of treatment were taken at monthly intervals for the first 3 months, then at 2-monthly intervals up to the end of therapy, and finally 2 months post-therapy. These were reviewed and the changes while on treatment noted and correlated with the clinical picture. Lung opacities were observed in 73 children (91 per cent) and were the most common radiological finding on the initial chest X-ray. These were followed by reduced chest wall muscle bulk present in 66 children (83 per cent). Mediastinal and/or hilar lymphadenopathy was noted in 47 children with a significant occurrence in the 0-4 age group (p = 0.004). Pleural effusions, cavities and calcification were rare. Human immunodeficiency virus (HIV) seropositive children with PTB accounted for 87 per cent and carried a poor prognosis (p = 0.0007). The common chest radiographic findings in children with PTB include lung opacities with hilar/mediastinal lymphadenopathy. Pleural effusions, cavitation, calcifications, miliary spread and normal chest X-rays were rare. SCR are useful in monitoring response to treatment, detection of onset of secondary infections and complications. HIV positive patients carry a poor prognosis. Based on the results of this study, pre-treatment, 2 months after onset of treatment, and end of therapy radiographs are recommended as routine in children with a clinical suspicion of PTB.

Adolescent↗

Tumoral calcinosis: report of nine cases.

Radiological observations of nine cases of tumoral calcinosis are reported. CT appearances of intracranial lesions in one patient are described. All patients were confirmed by histopathology. After complete excision no recurrence was seen in eight of the patients after a mean follow up of 24 months. Incomplete excision led to recurrence in one case.

Adolescent↗

Radiological presentation of pulmonary calcinosis: case report.

A 64-year old man presented to the Department of Radiology for evaluation. He had a seven year history of chronic cough. The chest x-ray (CXR) done showed high density diffuse cotton wool parenchymal opacities in both lungs sparing the pleura and broncho vascular bundles. These were also demonstrated on CT. This type of pulmonary calcinosis did not fit in with the classical appearances.

Calcinosis↗

Congenital diaphragmatic hernia: report of three cases.

Three cases of congenital diaphragmatic hernia (CHD) are presented with special emphasis on a neonate with an unusual combination of abnormalities. It was noted that in all three the hernias were of the Bochdaleck's type. CDH may not always be a single isolated failure of closure of the pleural peritoneal hiatus but a more complex multi organ anomaly.

Abnormalities, Multiple↗

Bilateral massive galactoceles. An atypical presentation.

Two cases of atypical presentation of galactoceles are reported. Both young women were referred to Mulago Hospital, Department of Radiology for breast imaging because of painful enlargement of both breasts. Both were found to be young lactating mothers. Ultrasound and aspiration was done on both of them. Ultrasound showed cystic lesions in both women. A milky solution was aspirated in both cases.

Adult↗

Non-invasive diagnosis of tropical splenomegaly syndrome.

A study of 41 clinically diagnosed cases of possible tropical splenomegaly syndrome (TSS) was undertaken in Mulago Hospital, Kampala, Uganda, to determine the appropriateness of liver ultrasonography in confirming a diagnosis of TSS. Definitive diagnosis of TSS was made on liver biopsy in 35 (85%) cases. Abdominal ultrasound showed that 30 of the confirmed cases of TSS had normal liver echo-texture and portal vein diameter, and five had abnormally increased liver echo-texture. The combination of massive splenomegaly and hepatomegaly, together with normal ultrasound features of the liver was highly suggestive of TSS. The sensitivity of this criterion was 86% and the specificity was 83%. This non-invasive approach to the diagnosis of TSS is associated with less hazards than liver biopsy, and a normal echogram could be used to make the diagnosis in over 80% of cases, in the field where histopathology may be lacking.

Adolescent↗