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Biomedical subjects

M G Levadnaia

Publications and source records attributed to M G Levadnaia.

5 recordsLinked to original sources
PubMed1985

[Granulomatous hepatitis].

The diagnosis of granulomatous hepatitis was made on the basis of granulomas observed in the liver biopsies from 64 patients. It is shown that the macrophagal granulomas are, as a rule, localized inside the lobules, do not possess the characteristic features and represent the morphological manifestations of a non-specific reactive hepatitis. At the same time macrophagal granulomas may be a stage in the formation of the epithelioid-cell granulomas. The latter reflect the long persistence of the antigen in the liver macrophages. In certain cases the epithelioid-cell granulomas acquire specific features and these allow one, when analysing the liver biopsies, to confirm or to suggest the etiology of the disease (sarcoidosis, tuberculosis). An essential help in establishing the etiology of granulomatous hepatitis comes from the repeated clinical examination of patients and repeated liver punctures.

Chronic Disease↗
PubMed1984

[Morphological diagnostic criteria of nonspecific reactive hepatitis].

The material of 100 punch liver biopsies from patients with a secondary nonspecific reactive hepatitis as a complication of chronic disease of the alimentary canal (gall bladder, pancreas, stomach and intestine) was studied. The criteria of morphological diagnostics of this hepatitis were elaborated. It is established that the morphology of the nonspecific reactive hepatitis depends on the pathogenesis and clinical course of the underlying disease. The response of liver macrophagal system is a basis of inflammatory changes.

Biopsy, Needle↗
PubMed1983

[Clinico-morphological characteristics of nonspecific reactive hepatitis].

Nonspecific reactive hepatitis is a manifestation or complication of various diseases, being a variety of secondary hepatitis. Its morphological characteristics are identical in all cases comprising hydropic and fatty degeneration of hepatocytes, their focal necroses in different parts of the lobules, predominantly macrophage and leukocyte infiltration of portal and intralobular stroma. Different morphological types of nonspecific reactive hepatitis are distinguished with regard to location of inflammatory lesions in different parts of the lobules and to their degree of activity. Morphological differential diagnosis of nonspecific reactive hepatitis from chronic hepatitis of viral, drug, and alcohol etiology is described. However, problems of morphogenesis, mechanism of development and differential diagnosis of this kind of chronic liver inflammation have not been studied sufficiently as yet.

Chemical and Drug Induced Liver Injury↗