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Biomedical subjects

M G Maksud

Publications and source records attributed to M G Maksud.

At least 19 recordsLinked to original sources
PubMed1989

Physiological considerations in training young athletes.

Healthy children evidence smaller values of cardiorespiratory function than adults, but these are in proportion to the smaller body size. At birth, the distribution of muscle fibres and the activity of enzymes in muscle are different from in adults, but these differences disappear at about age 6. On the other hand, muscle fibre thickness increases from birth to about 18 years of age and this is concurrent with increases in muscular strength. The increase in maximal oxygen consumption (VO2max) that accompanies growth and maturation in the human has been attributed in the main to appreciating muscle mass. During exercise, heart rate and cardiac output increase in the child as in the adult, but the heart rate in the child is greater and the stroke volume smaller. Furthermore, the arteriovenous difference in oxygen is greater in the exercising child than in the adult. Children also evidence a diminished blood pressure response to exercise. It seems that control of ventilation at exercise is the same in children as in adults, but exercise ventilation has been reported to be less efficient in the child. The young are less capable of regulating core temperature at exercise than adults and are more readily dehydrated. Very limited data suggest that muscle energy substrate storage and utilisation in children are such that they are less capable of anaerobic metabolism than adults. Generally, children respond to aerobic training as do adults, but such training in the first decade of life has been reported to have negligible effects. Blood lipid levels in children seem to be favourably influenced by persistent endurance activity. Ventilatory efficiency of children at exercise is augmented by aerobic training. Maximal values of ventilation and breathing frequency are increased in children and youth by endurance training. Conflicting data exist regarding the influence of training upon the child's vital capacity. Pulmonary diffusion capacity in well trained children has been seen to be greater than in untrained youngsters and many workers have reported increased VO2max as an outcome of endurance training. Limited data indicate that the nature of training may alter muscle fibre distribution in youthful athletes, and that muscle fibre hypertrophy can be induced in the young by means of strength and power training.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗
PubMed1985

A model treadmill adaptation for wheelchair ergometry.

We have designed, constructed and tested a restraining apparatus to permit safe uninhibited hand propulsion of a wheelchair on a motor driven treadmill. The special design features of the tracking assembly minimize any potential hazard or apprehension associated with possible lateral or rearward displacement of a chair from the belt surface. Special linear bearings minimize any increase in rolling resistance (less than 1.23 X 10(-3) N force displacement) at speeds ranging from 4 to 282 m. min.-1. The supporting frame is adjustable for variations in treadmill belt widths and different model wheelchairs. Easy removal of the chair enables convenient conversion of the treadmill for walking/running activity.

Ergonomics↗
PubMed1984

Cardiopulmonary responses of asthmatic children to strenuous exercise. Effect of theophylline.

The purpose of the study were to investigate the cardiopulmonary adaptations of asthmatic children to physical exercise and to evaluate the effects of theophylline. Two groups of children were evaluated. Eight asthmatic children participated in two exercise sessions. Half of the patients received theophylline in predetermined doses during the first session and half prior to the second session. Seventeen normal children matched for age, height, and weight served as controls. Various cardiorespiratory parameters were measured every 2 minutes during exercise and prior to termination of maximal physical effort. The results indicate that children with chronic asthma reach the range of predicted maximal aerobic capacity for their age. Theophylline increases the endurance of asthmatic children to maximal physical efforts without improving the cardiorespiratory parameters that were measured. The use of theophylline in therapeutic doses appears safe under conditions of vigorous exercise.

Adolescent↗
PubMed1983

Time course of lung volume changes during prolonged treadmill exercise.

It has been known since the 1920s that runners completing marathon races have reduced forced vital capacity (FVC) values. To investigate the time course of these lung volume alterations, we measured FVC and residual volume (RV) in 11 runners before, after, and at 30-min intervals during a 2.5-h treadmill run at just under their marathon pace (70% VO2max). Mean distance run was 21.5 +/- 1.5 (SD) miles in the 2.5-h period. During the first 60 min, both RV and total lung capacity (TLC) decreased by 110 ml, however, this change was not significant (P greater than 0.05). A high correlation (r = 0.93) was observed between delta RV and delta TLC during the first 5 min, while FVC remained unchanged. From 60-90 min, all lung volumes remained constant. From 90-150 min, lung volumes changed in a direction similar to that observed after a marathon, i.e., FVC decreased significantly (5.51 to 5.37 liter between 90 and 150 min, P less than 0.05), TLC remained unchanged (7.41 vs 7.42 liter, P greater than 0.05), and RV showed a nonsignificant increase from 1.90 to 2.05 liter (P greater than 0.05). The data are consistent with multiple mechanisms playing a role in pulmonary function changes during prolonged exercise. The smaller mean decrease in FVC observed in this study, as compared to that found during a marathon, suggested that the marathon imposes a greater demand on the lungs than did treadmill exercise of the duration and relative intensity used in this study.

Adult↗
PubMed1982

Increases in plasma beta-endorphin/beta-lipotropin immunoreactivity after treadmill running in humans.

Six well-trained endurance athletes were studied to determine if submaximal treadmill exercise results in increased plasma levels of beta-endorphin/beta-lipotropin (Bh-Ep/Bh-LPH) immunoreactivity. Bh-Ep/Bh-LPH immunoreactivity was measured by radio immunoassay in plasma from six experienced runners before and after 30-min treadmill runs at a self-selected pace, 60 and 80% VO2 max, and a control experiment of 30 min rest. All tests were randomized and occurred during the same time of day for a given subject (0600--1500 h). Preexercise Bh-Ep/Bh-LPH values averaged between 10 and 20 pg/ml and increased two- to fivefold after each run. The increase was statistically significant (P less than 0.05) only after the 60% run when Bh-Ep/Bh-LPH increased to a mean of 58.3 pg/ml. A large individual variation in the Bh-Ep/Bh-LPH response to running was noted. Mood state and perceptual data were also collected, and no significant relationship with Bh-Ep/Bh-LPH was evident. These data suggest that the stress of treadmill running acts as a stimulus to greater Bh-Ep/Bh-LPH secretion, a reduction in its degradation, or a combination of these, which leads to increased levels of these ligands in venous blood. The physiological significance of these increased plasma levels is not clear.

Adult↗
PubMed1980

Physiological responses to exercise in chronic cigarette and marijuana users.

Several physiologic responses to graded exercise were determined in four groups of young adult blue-collar workers identified as users of (1) marijuana, (2) cigarettes, (3) both marijuana and cigarettes, or (4) neither substance. Using covariate analysis of variance to control for race, age, height and weight, the groups did not differ in estimated percent fat, lean body mass, hematocrit levels, or blood hemoglobin values. Heart rate and oxygen consumption responses also were similar at all levels of exercise. The mean minute ventilation and perceived exertion were found to be higher in cigarette smokers than non-smokers of cigarettes but aerobic power and the physical work capacity did not differ. The differences in pulmonary function observed suggest the need for further study on older populations of chronic cigarette and marijuana users.

Adult↗
PubMed1980

Aerobic work capacity and endurance during nutritional repletion of severely undernourished men.

Oxygen consumption in maximal exercise (VO2max) was found to increase during nutritional rehabilitation of severely undernourished, sedentary adult males only when dietary protein was increased from 27 to 100 g/day. Adequate caloric intake, maintained for 45 days before the increase in protein content of the diet, had no effect on VO2max. The VO2max values were found to correlate best with the creatinine excretion rates (an index of the muscle cell mass) at the different stages of repletion. The average increment in VO2max/muscle cell mass ratio, although significant, was of a small magnitude (+15%). The VO2max/muscle cell mass ratio correlated only with the blood and plasma volumes at the different stages of repletion. After 2.5 months of protein repletion the VO2max values were still lower than those in mildly undernourished or normal Colombian adult males. Maximal endurance time at 80% aerobic load decreased significantly from an average of 113 min at the beginning of hospitalization to 42 min at the end of the period of protein repletion. This could be the result of replacing carbohydrate calories with protein in the diet, producing depletion of muscle glycogen stores, and/or to "detraining" effects associated with sedentary hospital life.

Adult↗
PubMed1979

An assessment of cardiorespiratory adjustments of asthmatic adults to exercise.

The cardiorespiratory adjustments of asthmatic adults to submaximal and maximal workloads were investigated. Cardiorespiratory variables were measured every 2 min during exercise and at the end of maximal physical effort. Exercise-induced asthma (EIA) occurred in all asthmatic subjects while normal subjects maintained normal spirometry. The results suggest that asthmatic adults have no cardiac reserve or oxygen delivery limitations. They work under less efficient ventilatory conditions at submaximal workloads and have a significantly lower functional work capacity. The high degree of correlation between preexercise maximal midexpiratory flow rate (MMF) and maximum O2 consumption (max Vo2) suggests that the smaller airways contribute significantly to the observed abnormalities. We recommend that evaluation of antiasthmatic medications in exercise-induced asthma should take into consideration their effect upon smaller airways and cardiorespiratory variables.

Adult↗
PubMed1979

Functional assessment of nutritional status: heart rate response to submaximal work.

The heart rate response to submaximal treadmill work been calculated using the heart rates and oxygen intakes obtained from normally nourished and undernourished adult male subjects during a maximal oxygen consumption test. Increased severity of malnutrition was associated with an increased heart rate response to the same submaximal work loads. The response was observed to decrease during a period of high protein dietary repletion of the most severely malnourished subjects. The data suggest the possibility of developing a submaximal work test for use in the field to provide physiological data to supplement anthropometric and biochemical information used to assess the nutritional status of populations.

Adolescent↗
PubMed1979

Body composition during nutritional repletion of severely undernourished men.

Body composition was studied in severely undernourished adult male inhabitants of a rural area of Colombia to evaluate the extent and the time course of the changes occurring upon nutritional repletion. During a 45-day basal period on a low (26g/day) protein diet containing adequate calories, body fat depots increased significantly (mean +/- SD = +3.02 +/- 2.9 kg), and there was a significant decrease in cell hydration from 81.8 to 76.4% (-5.4 +/- 9.1%). Upon protein repletion (100 g/day), cell hydration decreased significantly to 71.4%, while body cell mass increased markedly (9.0 +/- 1.1 kg). During protein repletion, muscle cell mass increased significantly (+5.5 +/- 0.6 kg) and rapidly, while the increase in nonmuscle cells (+3.5 +/- 3.8 kg) and specifically in red cell mass lagged behind. With repletion, the changes in the absolute values for plasma volume (+0.4 +/- 0.13 liters) were significant, but those in extracellular fluid volume (-0.7 +/- 1.9 liters) were not. Thus, the major compositional changes observed occurred in the body fat and the body cell mass components; these occurred independently of each other.

Adipose Tissue↗
PubMed1979

Alterations in pulmonary function consequent to competitive marathon running.

This study was designed to investigate the mechanisms underlying the significant reductions in vital capacity after marathon racing originally reported over 50 years ago. Spirometric, maximum expiratory flow-volume (MEFV), DLCO and residual volume (RV) measurements were made on 13 runners (11 males and 2 females) 1--2 weeks prior to the marathon, immediately after finishing the race, and again the next day. An average 0.48 L (8.6%) reduction in post-race forced vital capacity (FVC) was accompanied by an equivalent increase in RV. Thus, total lung capacity did not change, and the reduction in FVC was a result of an expiratory rather than an inspiratory limitation. Post-race FEV1 and FEF200-1200 remained unchanged while FEV1-2, FEF1 and FEF2 were reduced 19.7, 26.7 and 23.3%, respectively. Mean DLCO was unchanged. Pulmonary function on the following day was similar to that observed on the control day. These data indicated that after the race, expiratory flow was unaffected at high lung volumes, but was decreased at low lung volumes (within the effort-independent portion of the MEFV curve). The results are compatible with small airway closure occurring at an increased lung volume, which would result in a decreased FVC and an increased RV.

Adult↗
PubMed1978

Adrenergic responses of asthmatic and normal subjects to submaximal and maximal work levels.

The response of the adrenergic system of asthmatic subjects to exercise and the role of plasma catecholamines in exercise-induced asthma were investigated. Plasma levels of norepinephrine and epinephrine were measured at rest, during and after exercise in 7 asthmatic and 9 matched normal subjects. Exercise-induced bronchospasm occurred in all asthmatic subjects following exercise, while no significant change was observed in the normal subjects. The results showed that plasma levels of norepinephrine and epinephrine at rest and changes that occcurred during and after exercise were similar in both normal and asthmatic subjects. These data suggest that the adrenergic response of asthmatics to the same relative exercise stress as reflected in plasma catecholamine levels does not differ from that of normal subjects. It appears that changes in the circulating catecholamines do not play a significant role in the pathogenesis of exercised-induced asthma.

Adrenergic Fibers↗
PubMed1978

Body composition in chronic undernutrition.

Anthropometric (height, weight, and skinfolds), biochemical (serum proteins, albumin, and cholesterol), metabolic (nitrogen balance and creatinine excretion), hematological (plasma volume, hemoglobin, hematocrit, bone marrow hemosiderin, percent transferrin saturation, vitamin B12, and folic acid) variables and body water compartments (total and extracellular) have been measured in 49 adult male subjects who exhibited a wide range of nutritional states from normal to severely undernourished. Changes in body composition associated with moderate degrees of nutritional compromise were related principally to decreases in body cell mass (-15%). Body fat was normal. With severe nutritional involvement, both fat depots (-29%) and body cell mass (-29%) were significantly diminished. Muscle cell mass was more affected than other cells in the body (-41%). These data could indicate that in the group with moderate compromise, energy reserves (and hence energy balance) were maintained but dietary protein deficiencies were not compensated for. Both calorie and protein deficiencies were evident in the subjects with severe undernutrition. Multiple regression equations (r greater than 0.8) were developed that allow prediction of muscle cell mass, fat-free weight, and body cell mass from simple anthropometry and serum albumin levels. Decreases in serum albumin concentration were best related to deficits in muscle mass (r = 0.77).

Adolescent↗
PubMed1978

Aerobic work capacity in chronically undernourished adult males.

Maximal O2 consumption (VO2max) and maximal endurance time at 80% Vo2max (T80) were determined in 49 subjects with varying degrees of nutritional compromise. Vo2max was lover by 21% and 52% in subjects with moderate and severe undernutrition, respectively, when compared to men with mild nutritional compromise. Most (80%) of the change in Vo2max could be related to the estimated differences in muscle cell mass (MCM). A significant reduction (-18%) in the Vo2max per unit of MCM was found in the severely undernourished subjects, indicating basic physiological changes. Total body hemoglobin showed the highest correlation with Vo2max (r = 0.709) and at constant MCM (partial r = 0.796). A multiple regression equation was derived to estimate the Vo2max of populations on the basis of simple anthropometry and blood hemoglobin levels. T80 (93-103 min) and estimated maximum sustained 8-h percent effort (32%) in mild, intermediate, or severe undernutrition were not significantly different; by contrast, endurance at a given absolute work load was markedly lower in severe undernutrition (8 vs. 1.5 h) due presumably to the difference in Vo2max.

Adipose Tissue↗