Biomedical subjects

M G Mendelsohn

Publications and source records attributed to M G Mendelsohn.

3 recordsLinked to original sources

PubMed1997

Soft-tissue shavers in pediatric sinus surgery.

Powered instrumentation represents the newest advance in endoscopic sinus surgery. These instruments can be used in a variety of areas of the nose and paranasal sinuses. They can be particularly helpful for sinus surgery in children, who have smaller anatomic spaces and closer proximity of vital structures. The shaving action combined with continuous real-time suction of the soft-tissue shavers can provide the technical advantage to allow greater precision and ease in performing pediatric endoscopic sinus surgery.

Choanal Atresia↗

PubMed1996

Multicentric metachronous pulmonary and intravagal paraganglioma: a case report with immunohistochemical findings.

An unprecedented presentation of multicentric paraganglioma in a 48-year-old man is described. One of the paragangliomas, originally diagnosed as a carcinoid tumor, presented as a lung mass and was removed. Four years later, an intravagal paraganglioma was discovered. The lung and intravagal tumors had identical morphologic and immunoreactive characteristics. Both tumors consisted of chief cells (type 1) and sustentacular cells (type 2). The chief cells were immunoreactive with neuroendocrine markers (synaptophysin and chromogranin), but nonreactive with epithelial markers (CAM 5.2, high- and low-molecular-weight keratins, epithelial membrane antigen, and carcinoembryonic antigen). The sustentacular cells were positive for S100 protein. Although pulmonary carcinoids may mimic paragangliomas and occasionally contain sustentacular cells, the diagnosis was rejected because the tumor cells did not demonstrate reactivity with epithelial markers.

Biomarkers, Tumor↗

PubMed1991

Retinoic acid regulates, in vitro, the two normal pathways of differentiation of human laryngeal keratinocytes.

We have investigated the regulation of the two normal differentiation pathways followed by laryngeal epithelium. Using a tissue culture system that permits growth of cells at the air-liquid interface in serum-free medium, we found that modulating the concentration of retinoic acid is sufficient to determine which pathway is used. At 10(-8) M retinoic acid, the cells form a stratified squamous epithelium which expresses the differentiation-specific keratin K13. At 10(-7) M retinoic acid, the cells form a ciliated pseudostratified epithelium, with no expression of K13. These results are distinct from those seen with foreskin keratinocytes, which have only a single pathway of normal differentiation.

Cell Differentiation↗