Biomedical subjects

M G Menefee

Publications and source records attributed to M G Menefee.

4 recordsLinked to original sources

PubMed1978

The Sézary syndrome. A case with fetal-type glycogen and lymphocytic lymphoma.

A patient had Sézary syndrome and lymphocytic lymphoma. Cytoplasmic inclusions within the Sézary cells were demonstrated by histochemistry and electron microscopy to be composed of fetal-type glycogen. Results of tests for the presence of virus were negative. It is suggested that the Sézary cell represents a reversion of metabolic systems to more youthful types. Previously reported differences in diastase reactivity of the PAS-positive cytoplasmic inclusions are probably based on whether the glycogen is in fetal or mature configuration.

Chlorambucil↗

PubMed1978

Chlamydia trachomatis endocarditis.

A case of infective endocarditis due to Chlamydia trachomatis immunotype F is reported. Multiple negative blood cultures were a major deterrant from the initial clinical diagnosis of infective endocarditis. Postmortem ultrastructural identification of Chlamydia in the aortic valve vegetation led to an intensive retrospective study of retrieved serum samples utilizing microimmunofluorescent tests. Likewise an unusual echocardiographic finding was discovered to be the ultrasonic visualization of an aortic ring abscess. No similar case could be found in the literature. Clinicopathologic correlations are presented.

Adult↗

PubMed1976

Light microscopic and ultrastructural observations of a metastasizing malignant epithelioid schwannoma.

The light microscopy and ultrastructure of a malignant epithelioid schwannoma are described. Characteristic cells resembling perineural elements with various degrees of differentiation were observed. Primitive epithelioid cells contained scant ergastoplasm, and few tubules and filaments, but did have abundant free ribosomes and Golgi membranes. Also noted were junctional complexes and focal fusion of plasma membranes, basal laminae were absent. Better differentiated cells were completely limited by a well-developed basal membrane and had an abundance of intracytoplasmic filaments and multiple pinocytotic vesicles. The intercellular ground substance was composed of numerous fine collagen fibrils and amorphous, basement membrane-like, electron-dense material. A striking ultrastructural similarity of the tumor cells to those encountered in ethylnitrosourea-induced malignant schwannomas in rats was noteworthy.

Adult↗

PubMed1975

Hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease). An electron microscopic study of the vascular lesions before and after therapy with hormones.

Eight patients with hereditary hemorrhagic telangiectasia and severe epistaxis were treated with norethynodrel with mestranol (Enovid). Biopsy specimens of typical lesions from two patients were taken for electron microscopy before and after several months of therapy. Characteristic endothelial cell damage and nectosis were noted in the dilated venules of patients before treatment but not after. Unlined channels of blood were found in connective tissue before treatment but not after. These are thought to arise from leaks in the affected venules, and it is suggested that later indothelial ingrowth gives rise to the propagation of lesions that are known to develop with age. Reduplicated basal laminae and regenerating endothelial cells were found both before and after treatment.

Biopsy↗