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Biomedical subjects

M G Schoon

Publications and source records attributed to M G Schoon.

10 recordsLinked to original sources
PubMed2003

Antinuclear antibody testing in obstetric patients.

OBJECTIVES: To assess possible associations between the presence of antinuclear antibodies (ANAs) and pregnancy outcome in order to determine the significance of this test in obstetric practice. METHODS: A case-control study was performed on 408 patients admitted to an obstetric high care unit and on whom ANA testing was consecutively performed. The study group consisted of 46 patients who tested positive for ANAs and a control group of 92 patients who tested negative for ANAs. In addition to demographic data, indications for admission and pregnancy outcome were compared between the two groups. RESULTS: Of the 46 patients with a positive ANA result, 28 had an antinuclear pattern, 13 an anticytoplasmic pattern and 5 an antinuclear and an anticytoplasmic pattern. No significant differences were observed between the two groups (ANA-positive and negative) with regard to demographic data, indication for admission, clinical and laboratory data, and pregnancy outcome. The patients were also tested for anticardiolipin antibodies, and significantly more patients with severe pre-eclampsia tested positive (24% versus 4.7%, p = 0.01). No difference in HIV status and presence of autoantibodies was found between the two groups. CONCLUSION: The presence of ANAs was not associated with adverse pregnancy outcome. Therefore routine patient testing for ANAs in an obstetric high-care unit is not recommended.

Adult↗
PubMed1997

Cardiac disease during pregnancy--a Free State perspective on maternal morbidity and mortality.

AIM: Description of maternal outcome of pregnancies complicated by cardiac disease. SETTING: Pelonomi Hospital, Bloemfontein. POPULATION: Black African women of low socio-economic background who presented with cardiac disease during pregnancy. SAMPLE: All patients who delivered from 1 January 1990 to 1 January 1995. DESIGN: Descriptive retrospective study. RESULTS: Cardiac disease complicated 0.6% of pregnancies. Rheumatic valvular disease dominated in this population. The maternal mortality rate was 9.5% while the maternal morbidity rate ranged from 50% to 100% for the various lesions. CONCLUSIONS: Cardiac disease in pregnancy has high maternal mortality and morbidity rates. Hypertension, anticoagulation therapy, late referrals and inadequate counselling were important contributing factors. A high priority should be given to meticulous contraceptive counselling in patients with cardiac disease. Collaboration between obstetricians, physicians and cardiothoracic surgeons in imperative.

Adult↗
PubMed1995

Maternal deaths in Bloemfontein, South Africa--1986-1992.

OBJECTIVE: Determination of the maternal mortality ratio and the main causes of maternal death. SETTING: Pelonomi Hospital, a tertiary care and referral hospital in Bloemfontein. METHODS: Review of prospectively completed structured questionnaires on all maternal deaths from 1986 to 1992. RESULTS: The maternal mortality ratio at our institution was 171 per 100 000 live births. Haemorrhage (25%), infection (24%) and hypertensive disease (18%) were the most important causes of death. Seventy-one per cent were direct obstetric deaths and 23% indirect; in the remaining 6%, the cause was uncertain. Of all deaths, 35% were considered preventable. CONCLUSIONS: The maternal mortality ratio has decreased since our previous report for the period 1980-1985, and haemorrhage has replaced infection as the leading cause of death.

Adolescent↗
PubMed1990

Blood pressure profiles and perinatal outcome in pregnant black women in Pelonomi Hospital, Bloemfontein, South Africa.

In a retrospective study, the antenatal records of 241 consecutive patients were analyzed. Maternal gravidity, age, blood pressure recordings, and fetal gestational age at birth, weight and perinatal deaths were recorded. Blood pressure recordings were done by the clinic staff with the patient in the supine position tilted 15 degrees to the right. Hypertension was defined as a diastolic pressure (Korotkoff phase 4) of 90 mmHg or more. Forty-one percent were classified as hypertensive. Hypertension before 33 weeks had a perinatal mortality of 264/1000.

Adult↗
PubMed1987

The value of laparoscopy in the diagnosis of acute pelvic inflammatory disease.

A total of 40 patients with acute pelvic inflammatory disease (acute PID) were examined over a period of 7 months to determine the diagnostic value of laparoscopic examination in these cases. The most important findings were: the clinical diagnosis of acute PID was confirmed by laparoscopy in 55% of patients; laparoscopy was especially of value in differentiating potentially lethal conditions such as ectopic pregnancy and acute appendicitis from acute PID in 15% of patients; laparoscopically obtained microbiological specimens provide a more accurate means of determining the microbiological aetiology of acute PID than vaginally obtained specimens.

Acute Disease↗
PubMed1984

Diagnostic laparoscopy and management of patients with confirmed acute pelvic inflammatory disease.

The clinical success rate in the diagnosis of acute pelvic inflammatory disease (PID) is unacceptably low. There is an invaluable role for laparoscopy in the diagnosis, investigation and treatment of patients with suspected pelvic infection. PID at Ngwelezana Hospital is predominantly gonococcal and a combination of penicillin G and clindamycin has proved highly effective in the management of these patients.

Acute Disease↗
PubMed1983

Laparoscopic diagnosis of acute pelvic inflammatory disease.

At Ngwelezana Hospital, 103 patients admitted from the outpatient clinic with a diagnosis of pelvic infection were laparoscoped and in only 63 was the diagnosis confirmed. A disturbingly high incidence of ectopic pregnancy (8 patients) was found.

Acute Disease↗