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Biomedical subjects

M G Seremetis

Publications and source records attributed to M G Seremetis.

12 recordsLinked to original sources

Left heart bypass without thoracotomy.

An effective, simple and rapidly installed temporary mechanical assistance to the heart is needed. It should be capable of sustaining adequate circulation for several weeks. Patients with extensive myocardial infarctions, complicated by cardiogenic shock, or in end-stage heart failure, and who are candidates for heart replacement by transplantation or by a mechanical device, would benefit from such circulatory assistance. A mediastinal route was developed in human cadavers and in dogs institute left heart bypass without thoracotomy. Anatomical studies demonstrated the accessibility of the left atrium via the anterior mediastinum. A silastic cannula was made that can be inserted, with the help of a stylet, in the left atrium, via a mediastinoscopy. Two balloons attached to the cannula secure it onto the atrial wall and prevent hemorrhage. The cannula is connected to an extracorporeal circuit that is able to pump up to 90% of the cardiac output back into a femoral artery. The insertion of the atrial cannula proved to be simple, and the system very effective.

Animals↗

Ruptures and perforations of the esophagus: the case for conservative supportive management.

A series of 31 patients treated for ruptures and perforations of the intrathoracic esophagus is reviewed. Eighteen of these patients underwent major thoracotomy; 11 were treated with minor procedures. Two died before treatment could be implemented. Of the 18 undergoing major operations, 7 died; among the 11 managed conservatively there was only 1 death. Based on this experience, we conclude that major surgical repair for esophageal perforation is often unnecessary. It has the additional drawback of sometimes resulting in equally serious secondary procedures.

Esophageal Diseases↗

Leiomyomata of the esophagus. An analysis of 838 cases.

Review of the world literature to the end of 1971 has provided data on 838 cases of esophageal leiomyomata, including our own 19 surgically removed lesions. Although esophageal leiomyoma is the most common of the benign tumors of the esophagus, it is still rare compared with carcinoma. It occurs in more men than women, by a ratio of 1.9 to 1. Over 50% of the patients with leiomyoma of the esophagus are asymptomatic. Dysphagia and vague pain are the most frequent symptoms. Pyrosis is mentioned in the literature as present in 40% of the cases, but it is considered mainly as symptom of coexistent hiatal hernia. Diagnostic problems often arise, as the smooth muscle tumors may mimic mediastinal neoplasms, cysts, or even aneurysms, or complicate coexisting hiatal hernia and esophageal diverticulum. Operative management by transthoracic enucleation is the procedure of choice, although resection of the esophagaus may be required in few cases. Postoperative morbidity is minimal and results are excellent.

Adult↗