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Biomedical subjects

M G Shandala

Publications and source records attributed to M G Shandala.

At least 19 recordsLinked to original sources
PubMed1995

[Methodical approaches to the assessment of population's domestic exposure to chemicals].

The paper deals with the specific action of biocidal agents of household chemistry as part of population's chemical loading. A concept of evaluation of disinfectants on human health was formulated and its guidelines are substantiated. For this, the author proposes to use criteria for membrane damaging and immunodepressive effect based on the non-invasive test-systems to identify the immunometabolic status of the body. He also defines the ways of searching the approaches to identifying a life-threatening abnormality in either prenosological status.

Deodorants↗
PubMed1991

[Current approach to hygienic evaluation of protective and damaging reactions of the immune system after exposure to environmental factors].

When studying the immune status of the organism the use of additional exposures allow to clear up the defective character of physiological functions even when overt changes are absent. Altitude chamber hypoxia++, reproduction of allergic reactions of the slow and non-slow types, pathogenic Escherichia infection followed by assessment of virulence factors were used as such a stress under exposure to chemicals, electromagnetic fields of radio frequencies. A model was developed for the determination of safe levels of exposure to environmental factors, which makes it possible to differentiate the damaging and defence action of antibodies on the basis of their influence on the fetus and offspring. The effects of antibodies characterized by the postimplantation mortality of fetuses may be used as a criterion of significance for the organism of shifts in immunological reactivity.

Air Pollutants↗
PubMed1991

[Hygienic significance of surface-active substances in the conditions of soil contamination with chemical substances].

Urgent problems of the interaction of surface-active substances (SAS) with other ingredients under the conditions of chemical soil pollution are discussed, in particular, under the conditions of irrigation of agricultural fields with treated municipal sewage containing detergents. Before the beginning of the irrigation season the content of anion SAS in the arable layer of the soil is 2.02-2.66 mg/kg. In the middle of the vegetation period the quantity of detergents is increased 3-4 times fold. The authors suppose, that SAS may influence translocation of heavy metals from soil into plants. However, this question should be studied more carefully in the conditions of field experience with various SAS concentrations in soil.

Agriculture↗
PubMed1989

Results of a United States and Soviet Union joint project on nervous system effects of microwave radiation.

During the course of a formal program of cooperation between the United States and the Soviet Union concerning the biological effects of physical factors in the environment, it was concluded that duplicate projects should be initiated with the general goal of determining the most sensitive and valid test procedures for evaluating the effects of microwave radiation on the central nervous system. This report details an initial step in this direction. Male rats of the Fischer 344 strain were exposed or sham exposed to 10 mW/cm2 continuous wave microwave radiation at 2.45 GHz for a period of 7 hr. Animals were subjected to behavioral, biochemical, or electrophysiological measurements during and/or immediately after exposure. Behavioral tests used were passive avoidance and activity in an open field. Biochemical measurements were ATPase (Na+, K+; Mg2+, Ca2+) and K+ alkaline phosphatase activities. Electrophysiological measurements consisted of EEG frequency analysis. Neither group observed a significant effect of microwave irradiation on open field activity. Both groups observed changes in variability of the data obtained using the passive avoidance procedure, but not in the same parameters. The U.S. group, but not the USSR group, found significantly less Na+,K+-ATPase activity in the microwave-exposed animals compared to the sham exposed animals. Both groups found incidences of statistically significant effects in the power spectral analysis of EEG frequency, but not at the same frequency. The failure of both groups to substantiate the results of the other reinforces our contention that such duplicate projects are important and necessary.

Adenosine Triphosphatases↗