Clinico-pathologic findings in young pigs fed different levels of selenium, vitamin E and antioxidant.
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Biomedical subjects
Publications and source records attributed to M G Simesen.
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A syndrome with lack of udder development in a high-yielding jersey herd is described. The syndrome first appeared in the herd about 10 years ago. To try to elucidate this syndrome the endocrine pattern visualized by serum estrogen (Fig. 1) and progesterone (Fig. 2) levels was followed in 12 parturient cows. One case of typical lack of udder development appeared and was followed up by slaughter and pathological and histological examinations (Fig. 3 and 4). Pedigree investigations indicated that genetics could be involved in the syndrome. The endocrine pattern observed combined with the lack of udder development seems to indicate a complex disorder in the hormonal regulation which trigger the maternal preparation and initiation of parturition.
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A review is given of the literature concerning the so-called plant induced calcinosis in animals (tabel I), i.e. diseases which in their patological-anatomical appearance show great similarities with vit. D-intoxication. The etiology of the diseases are discussed in view of the last 5--10 years rapid development of knowledge concerning vit. D3 metabolism. It is pointed out that the most recent results indicate that enzootic calcinosis is caused by a 1,25-dihydrocholecalciferol-glycoside, which is hydrolysed in the intestinal tract. By this reaction 1.25 (OH) 2 cholecalciferol--the biological active metabolite of vit. D3 -- is set free, and thus able to act directly on the intestinal absorption mechanism. By this reaction the point of calcium metabolism regulation is essentially by-passed and calcium and phosphate absorption proceeds essentially out of control, causing hypercalcaemia, hyperphosphataemia, hypersecretion of calcitonin and calcinosis.
A semiquantitative Mg-urine-test suitable for field examination of the Mg-status in ruminants has been tested under practical conditions. Good agreement between the semiquantitative test and quantitative atomic absorption Mg-estimations was found. It is recommended always to examine urine from at least two-three animals in a herd to get a reliable picture of the Mg-status of the herd.
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In an internordic field study of the effect of the Ca dose (6, 9 and 12 g) on the therapeutic result in parturient paresis, considerably better results were recorded in Finland than in the other countries at all dose levels. In Finland a full effect was obtained with 6 g, while in all others 9 g Ca yielded a significantly better result than 6 g. Raising of the dose to 12 g produced no improvement. There was a significant difference in therapeutic results between the two Finnish breeds. A larger number of fatal cases was recorded among paretic cows with plasma Ca greater then 8.0 mg/100 ml.
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