PubMed Health⌕ Search

Biomedical subjects

M G Tari

Publications and source records attributed to M G Tari.

At least 19 recordsLinked to original sources
PubMed1997

Immunotherapy with an alum-adsorbed Parietaria-pollen allergoid: a 2-year, double-blind, placebo-controlled study.

A double-blind, placebo-controlled study was performed in order to confirm the safety, suitability, and efficacy of an alum-adsorbed Parietaria judaica-pollen allergoid, Allergovit, for allergen-specific immunotherapy. Parietaria pollen is an important cause of pollinosis, particularly in the Mediterranean zone, where it may be encountered for up to 8-9 months of the year. It is an aggressive allergen, and the doses tolerated during immunotherapy are less than those achieved with grass pollen. This factor increases the desirability of using therapeutic preparations with minimal IgE-binding activity, such as allergoids, in order to reduce the risk of side-effects and enable patients to tolerate a higher dose of allergen, thereby increasing the chances of successful specific immunotherapy. Forty patients with rhinitis and/or asthma were allocated at random to active- or placebo-treatment groups at the beginning of the study. All patients received the active preparation during the second year of the study. Immunotherapy was well tolerated by all patients and the incidence of side-effects was low. Treatment resulted in significant reductions in specific cutaneous reactivity and increases in nasal tolerance. A progressive improvement in nasal inspiratory peak flow in association with the immunotherapy indicated a reduction in nasal inflammation. These objective assessments of efficacy endorsed the results from the patients' diary cards, which indicated significant improvements in symptoms and reductions in the use of medication. The immunologic activity of the therapeutic preparation was demonstrated by the induction of a significant specific-IgG antibody response, with increases in IgG4 during the second year of treatment. We conclude that the safety and efficacy of immunotherapy with the Parietaria allergoid make it suitable for consideration in the treatment of patients with Parietaria-pollen-induced rhinitis or asthma.

Adolescent↗
PubMed1983

Intropic effects of several antiarrhythmic drugs.

The effects of intravenous administration of several quinidine-like antiarrhythmic drugs (bunaftine, monochloroacetyl ajmaline, lidocaine, mexiletine, disopyramide, aprindine, diphenylhydantoin, procainamide) on left ventricular performance, evaluated by systolic time intervals (STI), were studied in 100 patients with atherosclerotic heart disease. The STI were measured: the pre-ejection period (PEP), the isometric contraction time (ICT), the left ventricular ejection time (LVET), corrected LVET (LVETc), and the PEP/LVET ratio. The degree of impairment of left ventricular performance was maximal after aprindine and disopyramide administration. This was demonstrated by significant increases in the PEP, ICT, and PEP/LVET and by significant decreases in LVET and LVETc, in patients in both III-IV and I-II NYHA classes. Bunaftine, monochloroacetyl ajmaline, and lidocaine induced a less marked impairment of myocardial performance, since the PEP, ICT, and PEP/LVET increases were not significant compared to controls in patients in NYHA class I-II, and since no variation of LVET and LVETc were observed. Mexiletine effects on myocardial performance appear to be intermediate between these groups of drugs. Diphenylhydantoin and procainamide, considered separately because of their effects on heart rate and blood pressure which are not possessed by the other drugs, induced significant increases of PEP in NYHA class III-IV patients. However, the effects of these 2 drugs on myocardial performance may have been underestimated, due to the concomitant hemodynamic effect of these drugs.

Ajmaline↗
PubMed1981

Non-invasive evaluation by thermistor plethysmography of left ventricular performance during dynamic exercise. Comparison with echocardiography.

The purpose of this study was to evaluate the reliability of two non-invasive techniques (STI and echocardiography) in assessing cardiovascular response during exercise. STI were obtained using a new carotid pulse transducer (thermistor pulse) proved to be reliable in exercise recording. The study population included 12 male rowers (age 15-20 years), who performed supine bicycle exercise; STI and echocardiographic recording of left ventricle were simultaneously obtained at rest and continuously throughout the exercise period. A negative linear correlation (r=-0.782; p less than 0.001) was found between PEP (pre-ejection period) and %LVID (fractional shortening of left ventricle), reliable indexes of cardiac contractility measured by the two techniques. A lower, but significant correlation (r=0.643; p less than 0.001) was present between ETI (left ventricular ejection time corrected by heart rate) and SV (stroke volume) indexes of pump function. The present study shows that STI measured with this new technique, can be employed in evaluating left ventricular function in those patients in whom a good echocardiogram is difficult to record during exercise.

Adolescent↗
PubMed1980

Effects of intravenous disopyramide on myocardial function in patients with different degrees of cardiac failure.

The effects of intravenous disopyramide phosphate on myocardial function were evaluated by non-invasive indices of cardiac performance (systolic time intervals, STI) in 15 patients with atherosclerotic heart disease and different degrees of cardiac failure. Disopyramide (1.5 mg/Kg) was given intravenously over a period of 5 min. This drug induced in patients in I-II classes of NYHA a significant decrease of LVETc, while PEP, ICT, and PEP/LVET ratio rose significantly. STI were affected much more markedly in patients in III-IV classes of NYHA. Particularly affected were contractility indices (PEP, ICT, PEP/LVET), which were reduced significantly more in patients in III-IV classes as compares to patient in I-II classes. In contrast, LVETc, which correlates to stroke volume and cardiac output, was similarly worsened by the drug in the 2 groups of patients. Therefore, this study shows that disopyramide has relevant depressant effects on myocardial performance, simultaneously reducing stroke volume and contractility, and that the effect on contractility is more marked in patients with severe left ventricular impairment.

Arrhythmias, Cardiac↗
PubMed1980

Relationship between systolic time intervals and heart rate during atrial or ventricular pacing in normal subjects.

Systolic time intervals (STI) are regarded as good indices of cardiac performance in many heart diseases. It must be considered, however, that they are temporally related to the cardiac contraction cycle and, therefore, may be modified by heart rate changes. Thus, it is necessary to define the possible relationship between STI and heart rate changes. In this study, changes in heart rate were induced by atrial and ventricular pacing. Tachycardia caused a proportional decrease of left ventricular ejection time (LVET) (y=275.142-1.0025 x, r=0.76, p less than 0.001 for atrial pacing and y=298.28-0.691 x, r=-0.75, p less than 0.001 for ventricular pacing, respectively), but did not modify the pre-ejection period (PEP) and the isometric contraction time (ICT) and the electromechanical interval (QS1). These results demonstrate that while LVET must be corrected for the changes in heart rate, no correction of PEP and ICT is necessary.

Adult↗
PubMed1980

[Correlations between polygraphic and hemodynamic parameter changes induced by high concentrated oxygen administration in patients with mitral valvulopathy (author's transl)].

The goal of this study was to identify, utilizing apexcardiogram, other noninvasive parameters useful to evaluate the functional condition of the pulmonary vascular bed in patients with mitral stenosis and insufficiency. The patients of both sexes with mitral stenosis and insufficiency underwent left and right heart catetherization and simultaneously a polygraphic study was performed. Recordings of polygraphic as well as hemodynamic parameters were performed under control condition and after 5 min breathing of 100% Oxygen administered by facial mask. These results indicate that changes in rapid filling angle have a close relationship with changes in pulmonary capillary wedge pressure and variation of rapid filling interval are correlated with changes in pulmonary capillary wedge pressure and variation of rapid filling interval are correlated with changes in cardiac output.

Administration, Intranasal↗
PubMed1979

[The effects of intravenous mexiletine on cardiac performance (author's transl)].

The effects of intravenous Mexiletine (Kö1173) on cardiac performance has been studied in 20 patients affected by myocardiosclerosis (10 patients were classified in the 1st or 2nd NYHA classes, 10 cases in the 3rd or 4th ones. Mexiletine (1.5 mg/Kg) was given intravenously over a period of 1 minute. The effect on myocardial function has been evaluated by means of the systolic time intervals (STI). The drug caused non-significant changes of the left ventricular ejection time (LVET); on the contrary it caused a significant increases of the pre-ejection period (PEP), isometric contraction time (ICT) and the PEP/LVET ratio. These alteration became evident after 5--10 minutes and disappeared about 30 minutes after administration of the drug.

Adult↗
PubMed1979

[Clinical and hemodynamic effects of disopyramide phosphate administered i.v. in cardiopathic subjects (author's transl)].

The antiarrhythmic action of disopyramide (1.5 mg/Kg) administered i.v. as a bolus was assessed in 30 patients with ischemic heart disease and different arrhythmias. In 75% of supraventricular parossistic tachycardia and in 75% of parossistic atrial fibrillation, arrhythmia was interrupted within few minutes from drug injection; in 90% with premature ventricular contractions (PVC) and in 100% of ventricular tachycardia, disopyramide was capable to interrupt the arrhythmias. The hemodynamic effects of the same dose of disopyramide were evaluated in other 17 patients, 9 of which in I-II class NYHA and 8 in III-IV class. We used STI's as parameters of cardiac performance. In all patients following the injection of disopyramide, a significant increase of PEP, ICT and PEP/LVET ratio and a significant decrease of LVETc were observed. Thus, the disopyramide impaired cardiac performance and its effect appeared more evident in patients in III-IV class NYHA. In conclusion, disopyramide showed to be effective in interrupting different arrhythmias; however, its depressant action on cardiac performance suggests that caution should be used in patients with severely impaired myocardial function.

Adult↗
PubMedDate not supplied

Immunotherapy by inhalation of allergen in powder in house dust allergic asthma--a double-blind study.

The authors report the analysis of clinical and immunological parameters during local immunotherapy (LI) by inhalation of an extract in powder in patients with allergic asthma due to D. pteronyssinus (DP). The study was double-blind and lasted 24 months. Twenty-four patients were randomly assigned on a double-blind basis to receive by inhalation increasing doses of a micronized, freeze-dried DP extract in powder (14 patients, active therapy) or capsules of lactose (10 patients, placebo group). Results showed a statistically lower symptom score, a significant increase in bronchial tolerance to the allergen and significant levels of DP-specific IgG in actively treated patients compared to those treated with placebo.

Administration, Inhalation↗