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Biomedical subjects

M G Voronkov

Publications and source records attributed to M G Voronkov.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Effect of 1-(chloromethyl)silatrane on the alteration of the blood elements during extracorporeal circulation].

The damaging effect of cardiopulmonary bypass on blood elements and the possibility of its correction with 1-(chloromethyl) silatrane have been investigated. Cardiopulmonary bypass is a powerful damaging factor producing a wide range of effects including the activation of lipid peroxidation, reduction of erythrocyte membrane resistance to ultra-sound, destruction of blood elements and appearance of hemoglobin in the plasma (hemolysis). A possible mechanism of cardiopulmonary bypass damaging effect on blood elements is suggested. The use of 1-(chloromethyl)silatrane drastically increases the resistance of blood element membranes to injury, which seems promising for the drug application during cardiopulmonary bypass.

Animals↗
PubMed1984

[Effect of 1-(chloromethyl)silatrane on biochemical indices in the tissue of experimental gastric ulcer].

It has been demonstrated in rats with experimental gastric ulcer that 1-(chloromethyl) silatrane intensifies the development of granulation-fibrous tissue and favours optimization of the ratio of collagens and glycosaminoglycans, the main connective tissue biopolymers. Furthermore, 1-(chloromethyl) silatrane produces a more pronounced effect on hexosamine-containing glycoproteins in the ulcer tissue as compared with methyluracil and oxyferriscorbon. At the same time, judging by the time course of sialoproteins, the antiulcerous drugs, methyluracil and oxyferriscorbon, are much more effective antiinflammatory agents than 1-(chloromethyl)silatrane.

2,3-Diketogulonic Acid↗
PubMed1983

[Silatranes as stimulators of the development of granulation tissue].

Experiments on rats were made to study the effect of I-(chloromethyl) silatrane and I- (ethoxy) silatrane and that of triethanolamine and chloromethyl triethoxysilane on biochemical parameters of granular-fibrous tissue. The preparations were applied to a wound defect in the form of liniments. Silatranes were found to stimulate proliferation of the cells and to increase their biosynthetic activity, to favour accumulation of collagen and non-collagenic proteins, and reduction of the inflammatory phenomena. The silicon-containing fragment of the silatrane molecule chloromethyl triethoxysilane produced an analogous but less marked action. Triethanolamine containing no silicon was found to be as less active. These data indicate that silicon entering the silatrane grouping is of great importance for the occurrence of its biological activity.

Animals↗
PubMed1983

[Use of silatranes in combination with Vishnevskii'n ointment in wound treatment].

Experiments on rats were performed to study the effect of I-/chlormethyl/silatrane and I-/ethoxy/silatrane as well as that of triethanolamine and /chlormethyl/triethoxysilane on the biochemical characteristics of granular-fibrous tissue. The drugs were applied to the wound in the form of liniments. Silatranes stimulated cell proliferation and raised biosynthetic activity of the cells. They also favoured collagen and non-collagenous protein accumulation and reduced the inflammatory manifestations. The silicon-containing fragment of the silatrane molecule, /chlormethyl/triethoxysilane, produced an analogous but less pronounced action. Triethanolamine containing no silicon appeared to be far less active. These data indicate that the presence of silicon in the silatrane grouping is of great importance for its effective biological function.

Animals↗
PubMed1979

[Antibacterial and antiviral activity of the polychloroethyl- and beta,beta-dichlorovinylamides of carboxylic acids].

A number of compounds having antiviral and antibacterial (antistaphylococcal) activity was found in the beta,beta-dichlorvinyl- and alpha-chlor(alpha-oxy)-beta,beta,beta-trichlorethylamide series of carboxylic acids. The antistaphylococcal activity of the compounds under study was found to depend, to a certain extent, ontheir chemical structure, whereas no such dependence was established in respect of their antiviral activity. In the treatment of combined influenza-staphylococcal infection a decrease in antistaphylococcal effect was observed, while antiviral activity remained stable.

Amides↗
PubMed1976

[Antibacterial and antiviral activity of beta,beta-dichlorvinylpyrrolidone].

Antiviral and antibacterial activity of chlorine-containing N-vinylpyrrholidon analogue - beta,beta-dichlorvinylpyrrholidon (first synthesized in 1970) was studied on a model of influenza A2 virus. Peculiarities of the influence of beta,beta-dichlorvinylpyrrholidon on the reproduction of microbial and viral agents under conditions of their isolated and combined cultivation were revealed.

Antiviral Agents↗