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M G Voronkov

Publications and source records attributed to M G Voronkov.

81 records · Page 5Linked to original sources
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[Atranes: their ulcerostatic effect and its possible mechanisms].

The ulcerostatic activity of methylethyl (sylathrane-1-ilmethyl) sulfoiodide, 1-(chlormethyl) sylatrane, and 1-(isopropoxy)hermatrane has been revealed at experimental acetate ulcer in rats. The effect of atranes was equal to that of oxyferriscorbone and exceeded that of methyluracil. All the compounds studied inhibited peroxide oxidation of lipids in blood and stomach tissues from ulcer and in model experiments in egg yolk liposomes. The processes of ulcer development and photodynamic effects of lipid peroxidation in biological objects have been summarized. The data obtained allow to conclude that the ulcerostatic mechanism of action effect of atranes and the comparable drugs is based on their antioxidative effect.

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[1-Ethoxysilatrane: ulcerostatic effect and its possible mechanisms].

Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.

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[The action of the alkanol ammonium salts of aroxyacetic acids on the thrombocyte aggregation process].

Tris(2-hydroxyethyl)ammoniates of ezo-substituted aroxyalkane-carboxylic acids were examined for their effects on in vitro platelet aggregation under the influence of biogenic amines, as well as in lipid peroxidation. Hemocoagulation was evaluated in vivo. The agents tested were demonstrated no be a promising class of platelet aggregation inhibitors. They possess antioxidative effects, by reducing the level of malonic dialdehyde in induced hyperaggregation and the rate of lipid peroxidation. When given to animals, the agents decreased the activity of prothrombin factors.

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[The immunoactive properties of trekrezan].

It was shown that in vivo trecrezan possessed strong immunoactive properties: it decreased the spot-forming activity of polypotent stem blood cells, stimulated lympho- and hemopoesis, antibody formation, possessed steady antiinflammatory activity. It stimulated in vitro mononuclear cell proliferation in man due to its direct action on B lymphocytes and increase in lymphokine and monokine production.

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[Krezatsin--a stimulant of the activity of regenerating liver cells].

In experiments with partial hepatectomy in rats, the application of cresacin was shown to potentiate processes of hepatocyte regeneration, to increase high-energy compounds therein, and to accelerate some phases of mitotic cycle. These processes occur along with an inhibition of lipid peroxidation in hepatocytes, a decrease in the rate of transmembrane oxygen transport in mitochondria, and a reduction of cytochrome oxidase amount. It was concluded that cresacin directly stimulates diverse links of metabolic pathway.

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