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M Gómez Dorronsoro

Publications and source records attributed to M Gómez Dorronsoro.

4 recordsLinked to original sources
PubMed2001

[Primary neuroectodermal tumor (PNET) of the kidney: 26 cases. Current status of its diagnosis and treatment].

OBJECTIVE: To report a case of primitive neuroectodermal tumor (PNET) of the kidney and review the literature and the 25 cases previously reported as PNET. METHODS: A 39-year-old man who consulted for nephric colic is described. Ultrasound evaluation disclosed a mass arising from the left kidney. The clinical, radiological and pathologic features, treatment and differential diagnosis of small cell tumors are discussed, as well as the important role of immunohistochemical techniques (positive staining with O13 or 12E7 antibodies) and cytogenetic analysis [a characteristic chromosomal translocation t(11;22) (q24;q12) or variant translocation, such as t(21;22) (q22;q12), may be detected by fluorescence in situ hybridization (FISH) or polymerase chain reaction-reverse transcriptase (PCR-RT)]. RESULTS: Survival of our patient was 20 months. Only three of the 25 previously reported cases had a longer survival: 60, 48 and 24 months. Mean survival was 10 months. 95.24% of the cases were positive for NSE. Immunostaining (CD99) was performed in 16 patients and was found to be positive in all cases. Cytogenetic and molecular analyses were performed in 11 cases; PCR-RT was negative in two, as well as in the case described herein. CONCLUSIONS: PNET is a highly aggressive neoplasm that tends to recur locally and to metastasize. Despite the poor response to standard therapy combining surgical resection, postoperative irradiation and chemotherapy, the results might change due to current research on genetic therapy based on creating antisense oligonucleotides against the EWS-FLI 1 fusion gene.

Adult↗
PubMed1999

[Thoracic hydatidosis. Our experience in the last 15 years].

Hydatidosis in Spain has been a relevant public health problem which has been partly solved due to the implementation of different preventive programs. In this work the thoracic hydatidosis cases diagnosed at our hospital during the last 15 years are reported. Forty patients with thoracic hydatidosis are analyzed. Most of them had pulmonary hydatidosis (32), 14 had liver and lung cysts, and in eight cases of thoracic hydatidosis there was no pulmonary involvement; eight patients had been operated previously because of hydatidosis. A discussion follows of the epidemiologic, clinical and radiologic characteristics, as well as laboratory data, endobronchial changes, diagnostic cost/effectiveness of bronchoscopy when performed, and results after surgery. To remark the high percentage of complicated hydatidosis and uncommon locations, seven cases of multiple hydatidosis (two of them with cardiac involvement), five cases had hepato-thoracic communication, three with chest wall involvement, and one with exclusive cardiac involvement, as well as one case of calcified pulmonary hydatidosis. In most patients (37), treatment was surgery with a low number of complications at post-surgery (3). Three relapses were noted at follow-up.

Adolescent↗
PubMed1996

[Small renal cell carcinoma of the prostate with cerebral metastasis].

Presentation of one case of non-differentiated small cell prostate carcinoma, not associated to adenocarcinoma, in a male patient diagnosed with Benign Prostate Hyperplasia and Lymphoproliferative Syndrome, seen at the clinic due to worsening of mictional symptomatology. The diagnosis of non-differentiated carcinoma was reached through transrectal biopsy of a prostate node. Initial staging after diagnosis was T4a, N2, M1c (TNM, 1992), as liver and brain metastasis were already present. No bone or lung involvement was found. Specific Prostate Antigen value was 7.4 ng/ml, Carcino-Embryonary Antigen (CAE) was normal and ACTH slightly elevated. Differential diagnosis was primarily established with lymphoma. Using immunohistochemical techniques, the tumoral cells were positive for low molecular weight Keratin (CAM 5.2) and specific neuronal Enolase; negative for specific prostate antigen, prostate acid phosphatase, common leucocyte antigen and ACTH. The initial treatment consisted in one course of carboplatin plus VP-16 chemotherapy. The patient died six months after diagnosis.

Aged↗