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Biomedical subjects

M Góth

Publications and source records attributed to M Góth.

49 records · Page 3Linked to original sources
PubMed1984

Effect of thyrotropin-releasing hormone and gonadotropin-releasing hormone on serum TSH, PRL, hGH, FSH and LH in primary testicular failure and in hypogonadotrophic hypogonadism.

Infertile males with primary testicular failure, 6 with normal (Group I) and 7 with elevated gonadotropin levels (Group II), 9 patients with Klinefelter's syndrome (Group III) and 5 patients with hypogonadotrophic hypogonadism (Group IV) were investigated. Their serum TSH, PRL, hGH, FSH and LH responses to a single bolus of 200 micrograms TRH and 100 micrograms GnRH were measured and compared to the corresponding values obtained in 8 fertile healthy males of the same age group. The testosterone levels differed from the control only in the last two groups. Neither the basal TSH level nor the delta TSH differed between the groups. The latter was significant in all groups. The basal PRL level was similar in each group except in Group II. where the level was low. After TRH-GnRH treatment the PRL level increased significantly in each group but this increase was less in patients with hypogonadotrophic hypogonadism (9.94 +/- 2.6 nmol/l) when compared to the patients with primary testicular failure (Groups I, II, III, together, n = 22 17.10 +/- 2.12 nmol/l P less than 0.05). The basal levels of hGH and delta GH did not differ significantly between the groups. Both FSH and LH showed an exaggerated and protracted increase in patients with primary testicular failure with elevated basal gonadotropin level after TRH-GnRH, while in hypogonadotrophic hypogonadism the response was slight. Neither the serum testosterone nor the serum FSH or LH level influenced the response of TSH and hGH to the TRH-GnRH test.

Adolescent↗
PubMed1984

Hypoadrenia following adrenal venography in Cushing's disease.

Three patients with Cushing's disease are reported. In two patients the hyperfunction of the adrenal glands ceased following selective adrenal venography, moreover hypoadrenia has developed. In the third case necrosis following venography was proved by surgery and confirmed by histology. Regarding the therapeutic possibilities of Cushing's disease the use of this diagnostic procedure is taken into consideration but not recommended.

Adolescent↗
PubMed1982

[Simultaneous occurrence of pituitary adenoma and thyrogenic hyperthyroidism].

Subtotal tumour removal had been performed in a 34-year-old female patient for an extensive intra- and suprasellar expansive process. The considerably increased prolactin level did not decrease postoperatively, but normalised only after a three months bromocriptine treatment. The primary hyperthyroidism has been recovering after administering methimazolum. In a second case was reported on a 65-year-old female patient, suffering from rachitic dwarfism, stenosis of the aortic valve and tumour of the hypophysis, causing acromegaly, whose diabetes mellitus of contrainsular type could have been hardly balanced with insulin of a 128-unit-dose daily, and whose hyperthyroidism was due to an autonomous adenoma of the thyroid gland, first I-131 treatment was administered and she got into an euthyroid state. Six weeks following the removal of the acidophilic adenoma of the hypophysis administration of insulin could have been ceased, and the results of her growth hormone became normal. The clinical picture partly corresponds with Troell-Junet's syndrome.

Acromegaly↗
PubMed1982

Liquid crystal thermography of the testicles in the diagnosis of infertility.

The use of liquid crystal thermography (LCT) of the testicles in diagnosis of infertility was investigated. Varicocele, the most common cause of male infertility, is easily detectable by LCT. The technique may be used as a control after surgical treatment. In the majority of patients with oligo-azoospermia, LCT corresponded to physical examination of the testicles. In patients with oligo-azoospermia and both testicles normal to palpation, LCT is useful method for determining the colder testicle for biopsy purposes.

Adult↗
PubMed1982

The possible reason for serum 3,3'5'-(reverse) triiodothyronine increase in old people.

Healthy subjects aged 70-90 and 20-40 years were investigated for the level of reverse triiodothyronine (rT3). The mean level in 57 old subjects was higher and the triiodothyronine (T3) level lower than in 30 young persons. No negative correlation was observed. A serum T3 elevation caused by liothyronine administration (5-15 micrograms/day for two weeks) was not followed by a change of the mean rT3 level in 12 old subjects. After a single intramuscular thyrotropin (TSH) injection, the rT3 elevation lasted 24h longer in 19 old persons than in the 9 control ones, though the early rT3 response was similar in both groups. Propranolol administration (40 mg t.i.d. for a week) caused a similar rT3 elevation in old persons (n = 18) as in 12 young ones. From the indirect data it is concluded that the serum rT3 elevation in old age is a result of faster peripheral generation and not of increased production in the thyroid gland. The data do not indicate any change of rT3 metabolism. T4-T3 and T4-rT3 conversion are provoked by different enzymes. The elevation of rT3 might be a cause of the observed decrease in peripheral T3 generation in old subjects, acting by an inhibition of the T4-T3 conversion.

Adult↗
PubMed1981

Administration of antisomatotropin serum in diabetes mellitus.

The effect of antisomatotropin serum (ASS), raised in horse against human growth hormone, on the carbohydrate metabolism of diabetics has been investigated. Among the eight diabetic patients treated so far two had GH secreting pituitary adenoma, two insulin-dependent, and four others adult onset diabetes mellitus. The glucose tolerance curve improved in all but one patient. The effect lasted for two--four weeks. Because of this short time of efficiency, the place of ASS in the definite treatment of diabetes mellitus cannot been judged so far, however, its administration in diabetic retinopathy seems to be advantageous.

Adolescent↗
PubMedDate not supplied

Diagnosis from thyroid aspirates. Is the cytopathologist handicapped if not fully informed about the patient?

OBJECTIVE: When fine needle aspiration cytology (FNA) of the thyroid is performed as a first-line test, the cytopathologist cannot be fully informed about the patient's data. The authors investigated whether this decreases the accuracy of FNA and results in consequences for the patient. STUDY DESIGN: FNA smears of 202 patients, 190 with benign and 12 with malignant thyroid disease, were reevaluated, supplying the cytopathologist first with only information from the case history known already at the initial admission, and subsequently with full data. RESULTS: The FNA diagnoses were corrected in 13 cases; in 8/13 they showed a more serious finding. The therapeutic modality was changed in only one case. No corrections were made in the ultimately malignant cases. CONCLUSION: In several cases the cytopathologist may be handicapped by receiving only partial information about the patient, but in our patients this had no demonstrable adverse consequences. Thus, FNA can be performed upon patient's admission.

Biopsy, Needle↗
PubMedDate not supplied

Pituitary thyrotroph hypofunction in aged euthyroid subjects as assayed by the administration of iopanoic acid.

Iopanoic acid, an iodine containing contrast medium was administered orally to healthy subjects aged 20-40 years (n = 9) and 70-90 years (n = 10) and also to sick aged persons (aged 70-90 years, n = 10). Thyroid hormones: T4, T3, rT3, T3-uptake and thyrotropin (TSH) serum levels were estimated before and three and seven days after iopanoic acid. No significant TSH increase could be seen in the old-age groups: the T4 increases were similar in all three groups as well as the slight T3 decreases; the serum rT3 increase was significantly greater in the aged healthy and the sick subjects. The data suggests that in aged humans serum T4 elevation after iopanoic acid is a result of delayed thyroxine metabolism and not secondary to TSH release. Iopanoic acid administration is, aside from the TRH test, another model to demonstrate in geriatric patients thyrotroph hypofunction via the altered effect of inhibition of T4 deiodination on TSH release.

Adult↗