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Biomedical subjects

M Günaydin

Publications and source records attributed to M Günaydin.

At least 19 recordsLinked to original sources
PubMed2000

Surveillance of antimicrobial resistance among gram-negative isolates from intensive care units in eight hospitals in Turkey.

With the participation of eight major reference hospitals in Turkey, 749 aerobic Gram-negative isolates obtained from 473 intensive care patients in 1997 were tested for their susceptibility to 13 commonly employed antibacterial agents. The frequency with which species were isolated and resistance rates were compared with data from the previous 2 years. Imipenem was the most active agent against the majority of isolates (75%), followed by ciprofloxacin, cefepime and amikacin. The per cent susceptibility to all antibiotics declined from 1995 to 1996. With the exception of imipenem, for which there was no change in resistance, the per cent susceptibility somewhat increased in 1997. However, it was still lower than in 1995.

Anti-Bacterial Agents↗
PubMed1999

A surveillance study of antimicrobial resistance of gram-negative bacteria isolated from intensive care units in eight hospitals in Turkey.

This study was carried out with the participation of eight hospitals in Turkey to determine the frequency of gram-negative bacteria isolated in intensive care units (ICU) and to compare their resistance rates to selected antibiotics. Aerobic gram-negative bacteria isolated from ICUs during 1996 were studied. Antibiotic susceptibilities to imipenem, ceftazidime, ceftazidime-clavulanate, ceftriaxone, cefotaxime, cefepime, cefodizime, cefuroxime, piperacillin/tazobactam, amoxycillin-clavulanate, gentamicin, amikacin and ciprofloxacin were determined by Etest. A total of 748 isolates were obtained from 547 patients. The majority of organisms were isolated from the respiratory (38.8%) and urinary tracts (30.9%). Pseudomonas spp. were the most frequently isolated gram-negative species (26.8%), followed by Klebsiella spp. (26.2%). Escherichia coli, Acinetobacter spp. and Enterobacter spp. were the other commonly isolated organisms. High resistance rates were observed for all antibiotics studied. Imipenem appeared to be the most active agent against the majority of isolates. Although resistance rates exceeded 50%, ciprofloxacin, cefepime and amikacin were found to be relatively effective. Extended-spectrum beta-lactamase (ESBL) production appeared to be a major mechanism of resistance to beta-lactam antibiotics. In contrast to ceftazidime-clavulanate, piperacillin/tazobactam showed poor activity against organisms thought to produce ESBL, suggesting the presence of an enzyme resistant to tazobactam action. This study has yielded high rates of resistance in aerobic gram-negative isolates from ICUs in Turkey. High resistance rates to all the other antibacterials studied leave imipenem as the only reliable agent for the empirical treatment of ICU infections in Turkey.

Drug Resistance, Microbial↗
PubMed1997

Unilateral inguinal ectopic scrotum and imperforate anus: a case report.

A case of an ectopic scrotum located in the right inguinal area is described. The left hemiscrotum was in normal location, and each hemiscrotum contained testis. The boy also had an infralevator-type anorectal malformation. Initially, anoplasty was performed, and scrotal reconstruction was carried out 1 month later. The authors also reviewed the embryological explanation of ectopic scrotum in the literature.

Abnormalities, Multiple↗
PubMed1997

Congenital lumbar hernia associated with the lumbocostovertebral syndrome: two cases.

Congenital hernias in the lumbar region are very uncommon. Two cases with congenital lumbar hernia associated with the lumbocostovertebral syndrome are presented. The first case of a 14-month-old girl presented with the type of a superior lumbar triangle hernia. The second case was a 2-year-old girl presenting with diffuse lumbar hernia. The anatomy, embryology and treatment of this congenital abnormality are discussed.

Child, Preschool↗
PubMed1997

Postpneumonic empyema in children treated by early decortication.

We performed early decortication in 32 cases of postpneumonic empyema during the period of February 1991 to December 1995. Twenty of them were male and 12 of them were female. We evaluated these cases retrospectively. Decortication was saved for the patients where antimicrobial therapy and closed-tube drainage had failed to achieve a cure and was performed on the 10-15th day after the diagnosis was established. Indications for the decortication were persistent fever (9), pulmonary air leakage (7), localized effusion (7), persistent respiratory distress (5) and pleural thickening without resolution (28). Decortication was performed through the standard posterolateral thoracotomy. Patients were discharged on the 8th postoperative day with minimal morbidity and no mortality. Because of the simplicity of the procedure (short hospitalization periods, low mortality and morbidity rates) good results were achieved with early decortication.

Adolescent↗
PubMed1996

A case of ectopic anus localized on the right gluteus.

A case of a gluteus-localized ectopic anus on the right side is described. A 5-month-old boy had a severe sacral anomaly with atrophy of the right lower extremity and a pes equinus deformity. Transcutaneous muscle stimulation showed a well-developed muscle complex, and parasagittal muscle fibers have been localized obliquely. Although he has severe sacral anomalies, the posterior sagittal anorectoplasty procedure could be performed. This unique case provides a good demonstration of not only the ectopically localized anus but also the ectopically localized muscle complex.

Abnormalities, Multiple↗
PubMed1996

Weil's disease: report of 12 cases.

The epidemiological distribution and clinical features of 12 cases of Weil's disease from Turkey, are reviewed. The disease is most common in male farmers from rural areas. Myalgia and jaundice were recorded in all patients. Signs included vomiting in 9 patients, haemorrhages in 6, and renal function was impaired in 6. Creatine phosphokinase levels were found above normal limits in 75% of the cases. Leptospires were demonstrated with dark-field microscopy in the blood of 9 and in the urine of 5 of these patients. The diagnosis was confirmed with microscopic agglutination test (MAT) as well as with ELISA. Ig M antibodies were detected in 11 (92%) of the patients and is an accurate marker for acute leptospirosis. Penicillin was used for therapy and the outcome was favorable in 10 patients. Two patients died. It should be kept in mind that leptospirosis is an extremely severe disease which requires appropriate examinations at the right moment.

Adult↗
PubMed1993

[Hepatitis markers in hemodialysis patients].

In this study, antibodies against blood-borne hepatitis viruses (Hepatitis B, C and D) were investigated by ELISA in 43 patients with chronic renal insufficiency, at Hemodialysis Unit of Ondokuz Mayis University, Faculty of Medicine. 32 (76.2%) of the patients were found positive Anti-HBc total antibody and 12 (27.5%) patients were HBsAg carriers. 14 (32.5%) patients had Anti-HBs which showed protective immunity. Anti-HBs antibody was found negative in 6 patients after Hepatitis B infection. 9 (75%) of the HBsAg carriers had Anti-Delta antibody. 34 (79.1%) patients showed Anti-HCV positivity, 6 (18.2%) of HCV seropositive patients were found to be positive for HBsAg. There wasn't any correlation between length of time on hemodialysis, age and seropositivity of hepatitis markers. A correlation was detected between multiple transfusion and Anti-HCV seropositivity. The prevalence of HBsAg, Anti-HBc total and Anti-HCV were sequentially found 6%, 38%, 1% among healthy blood donors taken as a control group. Hepatitis virus infection was frequently seen in hemodialysis patients because of multiple blood transfusion. Chronicity is high because of insufficiency of cellular and humoral immunity. Testing blood for hepatitis viruses markers before blood transfusion and Hepatitis B vaccination programme might control viral hepatitis infection in hemodialysis units.

Female↗
PubMed1993

[Hepatitis b seroprevalence in hospital personnel].

To investigate the epidemiology of viral hepatitis B (VHB) infection in Ondokuz Mayis University Hospital staff sera of 243 workers and 100 blood donors examined for HBsAg and Anti-HBs with ELISA. The prevalences of HBsAg and Anti-HBs among the workers were 8.6% and 33.7% and among the blood donors were 5 and 24%, respectively. The overall prevalence of donors was 29%. The risk of infection showed a correlation with age and working period but there was no difference according to the jobs and departments. According to these results hospital staff have a great risk for VHB and should be vaccinated for protection from the infection.

Adult↗
PubMed1992

[Importance of the enzyme-linked immunosorbent assay (ELISA) for the serologic diagnosis of tuberculosis].

Tuberculosis is still a major granulomatosis disease in developing countries. The diagnosis of tuberculosis infection frequently creates problems which is related to clinical, radiological and bacteriological investigations. Recently, immunoenzymatic assays provide hopeful results for the serodiagnosis of tuberculosis. In this study, ELISA was evaluated as a serodiagnostic test for tuberculosis. Sera were obtained from 40 pulmonary tuberculosis patients and 15 healthy volunteer donors. The results showed that ELISA could be used in the serologic diagnosis of pulmonary tuberculosis.

Antibodies, Bacterial↗
PubMed1991

[Incidence of rubella IgG antibodies in young girls].

Rubella IgG antibodies were searched in 222 sera from female students of Selçuk University School of Medicine and from Institute of Higher Education for Nurses aged between 18-20 years. Of these 31 (13.96%) were found seronegative by ELISA. We discussed the risk of infection of these young girls.

Adult↗